hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00522.1

Complex Portal: CPX-24697

Confidence: Extremely High

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Genename	Protein Name	Uniprot Annotation Score	Links
CFAP141	Cilia- and flagella-associated protein 141	3	UniProt NCBI
MZT1	Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1)	5	UniProt NCBI
MZT2B	Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B)	4	UniProt NCBI
NEDD1	Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1)	5	UniProt NCBI
NME7	Nucleoside diphosphate kinase homolog 7 (NDK 7) (NDP kinase homolog 7) (3'-5' exonuclease NME7) (EC 3.1.-.-) (Protein kinase NME7) (EC 2.7.-.-) (nm23-H7)	5	UniProt NCBI
TUBG1	Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1)	5	UniProt NCBI
TUBG2	Tubulin gamma-2 chain (Gamma-2-tubulin)	5	UniProt NCBI
TUBGCP2	Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97)	5	UniProt NCBI
TUBGCP3	Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98)	5	UniProt NCBI
TUBGCP4	Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76)	5	UniProt NCBI

Showing 1 to 10 of 10 entries

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Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-380270	9.66325302868e-16	0.888888888889	TUBGCP2 NME7 MZT1 NEDD1 TUBGCP4 MZT2B TUBGCP3 TUBG2	Recruitment of mitotic centrosome proteins and complexes
REAC:R-HSA-380287	9.66325302868e-16	0.888888888889	TUBGCP2 NME7 MZT1 NEDD1 TUBGCP4 MZT2B TUBGCP3 TUBG2	Centrosome maturation
REAC:R-HSA-380320	3.19233401146e-15	0.888888888889	TUBGCP2 NME7 MZT1 NEDD1 TUBGCP4 MZT2B TUBGCP3 TUBG2	Recruitment of NuMA to mitotic centrosomes
REAC:R-HSA-69275	1.42248546324e-12	0.888888888889	TUBGCP2 NME7 MZT1 NEDD1 TUBGCP4 MZT2B TUBGCP3 TUBG2	G2/M Transition
REAC:R-HSA-453274	1.54974012842e-12	0.888888888889	TUBGCP2 NME7 MZT1 NEDD1 TUBGCP4 MZT2B TUBGCP3 TUBG2	Mitotic G2-G2/M phases
REAC:R-HSA-68877	1.8344367333e-12	0.888888888889	TUBGCP2 NME7 MZT1 NEDD1 TUBGCP4 MZT2B TUBGCP3 TUBG2	Mitotic Prometaphase
GO:0000930	3.83684076505e-12	0.666666666667	TUBGCP2 MZT1 TUBG2 TUBGCP4 MZT2B TUBGCP3	gamma-tubulin complex
REAC:R-HSA-68886	4.6913619393e-10	0.888888888889	TUBGCP2 NME7 MZT1 NEDD1 TUBGCP4 MZT2B TUBGCP3 TUBG2	M Phase
GO:0007020	2.17807545594e-09	0.666666666667	TUBGCP2 MZT1 TUBG2 TUBGCP4 TUBGCP3 NEDD1	microtubule nucleation
REAC:R-HSA-69278	5.52227860343e-09	0.888888888889	TUBGCP2 NME7 MZT1 NEDD1 TUBGCP4 MZT2B TUBGCP3 TUBG2	Cell Cycle, Mitotic

Showing 1 to 10 of 36 entries

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Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
TUBGCP3	MZT1	1.0	0.204	structurally_consistent (Q9BSJ2) structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
MZT2B	TUBGCP2	1.0	0.604	structurally_consistent (Q96CW5) structurally_consistent (dimer)	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo fraction boldt_WMM
TUBGCP2	NME7	1.0	0.082		hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM
MZT2B	TUBG1	1.0	0.738		hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein ()
TUBG2	TUBG1	1.0		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TUBG2	TUBGCP2	0.999		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TUBGCP4	TUBG1	0.999	0.346	structurally_consistent (dimer)	hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM
TUBGCP3	TUBG2	0.999		structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TUBGCP4	NME7	0.999	0.114		hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM
TUBGCP3	NME7	0.999	0.068		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM

Showing 1 to 10 of 38 entries

Related Complexes

Genename	Complexes
TUBGCP3	huMAP3_00522.1 huMAP3_09443.1 huMAP3_14882.1
MZT2B	huMAP3_00522.1 huMAP3_09443.1 huMAP3_10467.1 huMAP3_14882.1
MZT1	huMAP3_00522.1 huMAP3_09443.1 huMAP3_14882.1
NEDD1	huMAP3_00522.1 huMAP3_09443.1 huMAP3_11190.1 huMAP3_14584.1 huMAP3_14882.1
TUBG2	huMAP3_00522.1 huMAP3_09443.1 huMAP3_14882.1
TUBGCP4	huMAP3_00522.1 huMAP3_09443.1 huMAP3_14882.1
CFAP141	huMAP3_00522.1 huMAP3_01284.1 huMAP3_09443.1 huMAP3_09578.1 huMAP3_11571.1 huMAP3_11862.1 huMAP3_11880.1 huMAP3_12530.1 huMAP3_12972.1 huMAP3_14883.1
TUBG1	huMAP3_00522.1 huMAP3_09443.1 huMAP3_14584.1 huMAP3_14882.1
TUBGCP2	huMAP3_00522.1 huMAP3_09443.1 huMAP3_14882.1
NME7	huMAP3_00522.1 huMAP3_01284.1 huMAP3_09443.1 huMAP3_09578.1 huMAP3_12630.1 huMAP3_14882.1