hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00522.1
Complex Portal: CPX-24697
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TUBGCP3 | Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) | 5 | UniProt NCBI |
| MZT2B | Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) | 4 | UniProt NCBI |
| MZT1 | Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1) | 5 | UniProt NCBI |
| NEDD1 | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | 5 | UniProt NCBI |
| TUBG2 | Tubulin gamma-2 chain (Gamma-2-tubulin) | 5 | UniProt NCBI |
| TUBGCP4 | Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) | 5 | UniProt NCBI |
| CFAP141 | Cilia- and flagella-associated protein 141 | 3 | UniProt NCBI |
| TUBG1 | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | 5 | UniProt NCBI |
| TUBGCP2 | Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) | 5 | UniProt NCBI |
| NME7 | Nucleoside diphosphate kinase homolog 7 (NDK 7) (NDP kinase homolog 7) (3'-5' exonuclease NME7) (EC 3.1.-.-) (Protein kinase NME7) (EC 2.7.-.-) (nm23-H7) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-380270 | 9.66325302868e-16 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-380287 | 9.66325302868e-16 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | Centrosome maturation |
| REAC:R-HSA-380320 | 3.19233401146e-15 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-69275 | 1.42248546324e-12 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | G2/M Transition |
| REAC:R-HSA-453274 | 1.54974012842e-12 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | Mitotic G2-G2/M phases |
| REAC:R-HSA-68877 | 1.8344367333e-12 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | Mitotic Prometaphase |
| GO:0000930 | 3.83684076505e-12 | 0.666666666667 | TUBGCP3 TUBGCP4 MZT1 TUBGCP2 MZT2B TUBG2 | gamma-tubulin complex |
| REAC:R-HSA-68886 | 4.6913619393e-10 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | M Phase |
| GO:0007020 | 2.17807545594e-09 | 0.666666666667 | TUBGCP3 TUBGCP4 MZT1 NEDD1 TUBGCP2 TUBG2 | microtubule nucleation |
| REAC:R-HSA-69278 | 5.52227860343e-09 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | Cell Cycle, Mitotic |
| REAC:R-HSA-1640170 | 2.90076944325e-08 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | Cell Cycle |
| GO:0046785 | 9.94849720688e-08 | 0.666666666667 | TUBGCP3 TUBGCP4 MZT1 NEDD1 TUBGCP2 TUBG2 | microtubule polymerization |
| CORUM:6893 | 1.30992062401e-07 | 0.333333333333 | TUBGCP3 TUBGCP2 TUBGCP4 | Gamma-tubulin complex |
| GO:0031109 | 7.29360409897e-07 | 0.666666666667 | TUBGCP3 TUBGCP4 MZT1 NEDD1 TUBGCP2 TUBG2 | microtubule polymerization or depolymerization |
| WP:WP4940 | 1.2353479002e-06 | 0.333333333333 | TUBGCP3 TUBGCP2 TUBGCP4 | 15q11 2 copy number variation syndrome |
| GO:0005813 | 1.48170310221e-06 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | centrosome |
| GO:0015630 | 1.80189794686e-06 | 1.0 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 CFAP141 MZT2B TUBG2 | microtubule cytoskeleton |
| GO:0005815 | 5.7521683782e-06 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | microtubule organizing center |
| GO:0051258 | 2.47340384151e-05 | 0.666666666667 | TUBGCP3 TUBGCP4 MZT1 NEDD1 TUBGCP2 TUBG2 | protein polymerization |
| GO:0043015 | 4.16991368105e-05 | 0.444444444444 | TUBGCP3 TUBGCP2 NEDD1 TUBGCP4 | gamma-tubulin binding |
| GO:0005856 | 7.17807337201e-05 | 1.0 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 CFAP141 MZT2B TUBG2 | cytoskeleton |
| GO:0000923 | 8.06911104389e-05 | 0.333333333333 | TUBGCP3 TUBGCP2 TUBGCP4 | equatorial microtubule organizing center |
| CORUM:3714 | 8.20609246787e-05 | 0.222222222222 | TUBGCP3 TUBGCP2 | Pericentrin-GCP complex |
| GO:0000931 | 0.00045145282213 | 0.333333333333 | MZT2B MZT1 TUBGCP4 | gamma-tubulin ring complex |
| GO:0007051 | 0.000956173792457 | 0.555555555556 | TUBGCP3 TUBGCP2 TUBGCP4 MZT1 TUBG2 | spindle organization |
| WP:WP3998 | 0.00132075556609 | 0.333333333333 | TUBGCP3 TUBGCP2 TUBGCP4 | Prader Willi and Angelman syndrome |
| GO:0051011 | 0.00177138039123 | 0.333333333333 | TUBGCP3 TUBGCP2 TUBGCP4 | microtubule minus-end binding |
| GO:0000226 | 0.00550771776764 | 0.666666666667 | TUBGCP3 TUBGCP4 MZT1 NEDD1 TUBGCP2 TUBG2 | microtubule cytoskeleton organization |
| GO:0005874 | 0.0127581775757 | 0.555555555556 | TUBGCP3 TUBGCP2 TUBG2 NME7 CFAP141 | microtubule |
| GO:0051225 | 0.0137151687321 | 0.444444444444 | TUBGCP3 TUBGCP2 MZT1 TUBGCP4 | spindle assembly |
| GO:0097435 | 0.0185376153333 | 0.666666666667 | TUBGCP3 TUBGCP4 MZT1 NEDD1 TUBGCP2 TUBG2 | supramolecular fiber organization |
| GO:0005819 | 0.0214567837679 | 0.555555555556 | TUBGCP3 TUBG2 MZT1 NEDD1 MZT2B | spindle |
| HPA:0330222 | 0.0234578036135 | 0.888888888889 | TUBGCP3 NME7 TUBGCP4 MZT1 NEDD1 TUBGCP2 MZT2B TUBG2 | oral mucosa; squamous epithelial cells[>=Medium] |
| HPA:0570741 | 0.0257502851506 | 0.777777777778 | NME7 MZT2B MZT1 NEDD1 TUBGCP2 TUBGCP4 TUBG2 | testis; cells in seminiferous ducts[>=Low] |
| GO:0007059 | 0.0299482695318 | 0.555555555556 | TUBGCP3 TUBGCP2 TUBGCP4 MZT1 TUBG2 | chromosome segregation |
| GO:0007017 | 0.0416877457662 | 0.666666666667 | TUBGCP3 TUBGCP4 MZT1 NEDD1 TUBGCP2 TUBG2 | microtubule-based process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TUBGCP3 | MZT1 | 1.0 | 0.204 |
structurally_consistent (Q9BSJ2)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| MZT2B | TUBGCP2 | 1.0 | 0.604 |
structurally_consistent (Q96CW5)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () Malo fraction boldt_WMM |
| TUBGCP2 | NME7 | 1.0 | 0.082 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM | |
| MZT2B | TUBG1 | 1.0 | 0.738 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| TUBG2 | TUBG1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TUBG2 | TUBGCP2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TUBGCP4 | TUBG1 | 0.999 | 0.346 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM |
| TUBGCP3 | TUBG2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TUBGCP4 | NME7 | 0.999 | 0.114 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM | |
| TUBGCP3 | NME7 | 0.999 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only boldt_WMM | |
| TUBGCP3 | MZT2B | 0.999 | 0.22 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| MZT2B | TUBG2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TUBGCP3 | TUBGCP2 | 0.999 | 0.684 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| MZT1 | TUBG1 | 0.999 | 0.192 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| TUBG2 | TUBGCP4 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MZT2B | TUBGCP4 | 0.999 | 0.302 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () boldt_WMM | |
| MZT2B | NME7 | 0.999 | 0.034 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MZT1 | NEDD1 | 0.999 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| TUBGCP3 | TUBGCP4 | 0.999 | 0.108 | hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM | |
| MZT1 | TUBGCP4 | 0.998 | 0.112 |
structurally_consistent (Q96RT8)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| TUBG1 | NME7 | 0.998 | 0.03 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM | |
| TUBGCP4 | TUBGCP2 | 0.998 | 0.266 |
mutually_exclusive (Q9NRH3)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () boldt_WMM |
| TUBGCP3 | TUBG1 | 0.998 | 0.64 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM boldt_WMM | |
| NEDD1 | TUBGCP2 | 0.998 | 0.08 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| MZT1 | TUBGCP2 | 0.998 | 0.214 |
structurally_consistent (Q96CW5)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| MZT2B | MZT1 | 0.998 | 0.114 |
mutually_exclusive (Q9BSJ2)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| TUBG2 | NME7 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TUBG1 | TUBGCP2 | 0.998 | 0.93 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM | |
| MZT1 | NME7 | 0.997 | 0.074 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| MZT2B | NEDD1 | 0.997 | 0.04 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| NEDD1 | TUBGCP4 | 0.994 | 0.108 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () | |
| TUBGCP3 | NEDD1 | 0.993 | 0.182 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| NEDD1 | TUBG1 | 0.986 | 0.134 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| NEDD1 | NME7 | 0.979 | 0.042 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM | |
| CFAP141 | NME7 | 0.953 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MZT1 | TUBG2 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NEDD1 | TUBG2 | 0.143 | bioplex_WMM bioplex3_WMM WMM_only | ||
| CFAP141 | TUBG1 | 0.017 | bioplex3_HEK293 WMM_only |
Related Complexes