hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00528.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BRCA1 | Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1) | 5 | UniProt NCBI |
| BARD1 | BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2213 | 1.70876175213e-06 | 1.0 | BARD1 BRCA1 | BRCA1-BARD1-POLR2A complex |
| CORUM:201 | 1.70876175213e-06 | 1.0 | BARD1 BRCA1 | HUIC complex |
| REAC:R-HSA-9699150 | 1.70876175213e-06 | 1.0 | BARD1 BRCA1 | Defective DNA double strand break response due to BARD1 loss of function |
| REAC:R-HSA-9663199 | 1.70876175213e-06 | 1.0 | BARD1 BRCA1 | Defective DNA double strand break response due to BRCA1 loss of function |
| CORUM:2822 | 5.12628525639e-06 | 1.0 | BARD1 BRCA1 | E3 ubiquitin ligase (BRCA1, BARD1) - UbcH5c complex |
| CORUM:2783 | 5.12628525639e-06 | 1.0 | BARD1 BRCA1 | BARD1-BRCA1-CSTF64 complex |
| CORUM:2788 | 5.12628525639e-06 | 1.0 | BARD1 BRCA1 | BRCA1 B complex |
| CORUM:2818 | 5.12628525639e-06 | 1.0 | BARD1 BRCA1 | BRCA1-BARD1-BRCA2-DNA damage complex III |
| CORUM:2823 | 5.12628525639e-06 | 1.0 | BARD1 BRCA1 | BRCA1-BARD1-UbcH7c complex |
| CORUM:6946 | 5.12628525639e-06 | 1.0 | BARD1 BRCA1 | BARD1-BRCA1-RAD51 complex |
| CORUM:2786 | 1.02525705128e-05 | 1.0 | BARD1 BRCA1 | BRCA1 A complex |
| CORUM:2787 | 1.02525705128e-05 | 1.0 | BARD1 BRCA1 | BRCA1 C complex |
| CORUM:2211 | 1.70876175213e-05 | 1.0 | BARD1 BRCA1 | BARD1-BRCA1-CSTF complex |
| CORUM:2817 | 2.56314262819e-05 | 1.0 | BARD1 BRCA1 | BRCA1-BARD1-BACH1-DNA damage complex I |
| CORUM:2815 | 4.78453290596e-05 | 1.0 | BARD1 BRCA1 | BRCA1-BARD1-BACH1-DNA damage complex II |
| KEGG:03440 | 0.000126804361689 | 1.0 | BARD1 BRCA1 | Homologous recombination |
| HP:0030406 | 0.000310994638887 | 1.0 | BARD1 BRCA1 | Primary peritoneal carcinoma |
| WP:WP1971 | 0.000331996874241 | 1.0 | BARD1 BRCA1 | Integrated cancer pathway |
| GO:0031436 | 0.000468200720083 | 1.0 | BARD1 BRCA1 | BRCA1-BARD1 complex |
| REAC:R-HSA-9709603 | 0.000471618243588 | 1.0 | BARD1 BRCA1 | Impaired BRCA2 binding to PALB2 |
| REAC:R-HSA-9701192 | 0.000512628525639 | 1.0 | BARD1 BRCA1 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9704331 | 0.000512628525639 | 1.0 | BARD1 BRCA1 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| REAC:R-HSA-9704646 | 0.000512628525639 | 1.0 | BARD1 BRCA1 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9701193 | 0.000512628525639 | 1.0 | BARD1 BRCA1 | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-5693554 | 0.000599775374997 | 1.0 | BARD1 BRCA1 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| REAC:R-HSA-5689901 | 0.000645911942305 | 1.0 | BARD1 BRCA1 | Metalloprotease DUBs |
| REAC:R-HSA-5693568 | 0.000902226205124 | 1.0 | BARD1 BRCA1 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-9709570 | 0.000958615342944 | 1.0 | BARD1 BRCA1 | Impaired BRCA2 binding to RAD51 |
| REAC:R-HSA-5693537 | 0.000958615342944 | 1.0 | BARD1 BRCA1 | Resolution of D-Loop Structures |
| REAC:R-HSA-5685938 | 0.00101671324252 | 1.0 | BARD1 BRCA1 | HDR through Single Strand Annealing (SSA) |
| HP:0011027 | 0.00111069513888 | 1.0 | BARD1 BRCA1 | Abnormal fallopian tube morphology |
| WP:WP4016 | 0.00124541391542 | 1.0 | BARD1 BRCA1 | DNA IR damage and cellular response via ATR |
| REAC:R-HSA-5693616 | 0.00126619245833 | 1.0 | BARD1 BRCA1 | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-9701190 | 0.00133283416666 | 1.0 | BARD1 BRCA1 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| REAC:R-HSA-9675136 | 0.00133283416666 | 1.0 | BARD1 BRCA1 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-5693579 | 0.00147124386858 | 1.0 | BARD1 BRCA1 | Homologous DNA Pairing and Strand Exchange |
| HP:0012125 | 0.00180445241025 | 1.0 | BARD1 BRCA1 | Prostate cancer |
| HP:0100787 | 0.00180445241025 | 1.0 | BARD1 BRCA1 | Prostate neoplasm |
| WP:WP2263 | 0.00190046928652 | 1.0 | BARD1 BRCA1 | Androgen receptor network in prostate cancer |
| WP:WP5380 | 0.00194090480325 | 1.0 | BARD1 BRCA1 | 5q35 copy number variation |
| REAC:R-HSA-9675135 | 0.0020095038205 | 1.0 | BARD1 BRCA1 | Diseases of DNA repair |
| HP:0008775 | 0.00253238491666 | 1.0 | BARD1 BRCA1 | Abnormal prostate morphology |
| GO:0070532 | 0.0028092043205 | 1.0 | BARD1 BRCA1 | BRCA1-B complex |
| REAC:R-HSA-5693571 | 0.0031270340064 | 1.0 | BARD1 BRCA1 | Nonhomologous End-Joining (NHEJ) |
| REAC:R-HSA-5685942 | 0.00366529395832 | 1.0 | BARD1 BRCA1 | HDR through Homologous Recombination (HRR) |
| HP:0033019 | 0.0038549665128 | 1.0 | BARD1 BRCA1 | Male reproductive system neoplasm |
| REAC:R-HSA-5693565 | 0.00424627295404 | 1.0 | BARD1 BRCA1 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| REAC:R-HSA-5693606 | 0.00436759503844 | 1.0 | BARD1 BRCA1 | DNA Double Strand Break Response |
| REAC:R-HSA-69473 | 0.00639247771471 | 1.0 | BARD1 BRCA1 | G2/M DNA damage checkpoint |
| HP:0000022 | 0.00667442340382 | 1.0 | BARD1 BRCA1 | Abnormal male internal genitalia morphology |
| REAC:R-HSA-6804756 | 0.00669151102134 | 1.0 | BARD1 BRCA1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-5693607 | 0.00684359081728 | 1.0 | BARD1 BRCA1 | Processing of DNA double-strand break ends |
| GO:0070533 | 0.00702301080125 | 1.0 | BARD1 BRCA1 | BRCA1-C complex |
| HP:0100615 | 0.00710844888886 | 1.0 | BARD1 BRCA1 | Ovarian neoplasm |
| HP:0003002 | 0.00755614446791 | 1.0 | BARD1 BRCA1 | Breast carcinoma |
| HP:0002861 | 0.0077851185427 | 1.0 | BARD1 BRCA1 | Melanoma |
| HP:0002894 | 0.0105293899166 | 1.0 | BARD1 BRCA1 | Neoplasm of the pancreas |
| HP:0010785 | 0.0124910484081 | 1.0 | BARD1 BRCA1 | Gonadal neoplasm |
| REAC:R-HSA-5693567 | 0.0128208394262 | 1.0 | BARD1 BRCA1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| HP:0100013 | 0.0130822799743 | 1.0 | BARD1 BRCA1 | Neoplasm of the breast |
| GO:0110025 | 0.0131096201623 | 1.0 | BARD1 BRCA1 | DNA strand resection involved in replication fork processing |
| GO:0070531 | 0.0131096201623 | 1.0 | BARD1 BRCA1 | BRCA1-A complex |
| REAC:R-HSA-5693538 | 0.0141075370256 | 1.0 | BARD1 BRCA1 | Homology Directed Repair |
| REAC:R-HSA-5633007 | 0.0196097498674 | 1.0 | BARD1 BRCA1 | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.0211937720117 | 1.0 | BARD1 BRCA1 | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.0214637563685 | 1.0 | BARD1 BRCA1 | G2/M Checkpoints |
| HP:0010787 | 0.0282150740512 | 1.0 | BARD1 BRCA1 | Genital neoplasm |
| WP:WP5087 | 0.0293715080819 | 1.0 | BARD1 BRCA1 | Pleural mesothelioma |
| HP:0001442 | 0.0423875440233 | 1.0 | BARD1 BRCA1 | Typified by somatic mosaicism |
| GO:0085020 | 0.0426062655276 | 1.0 | BARD1 BRCA1 | protein K6-linked ubiquitination |
| CORUM:2824 | 0.0499419797295 | 0.5 | BRCA1 | BRCA1-RAD51 complex |
| CORUM:2820 | 0.0499419797295 | 0.5 | BRCA1 | BRCA1-VCP complex |
| CORUM:2813 | 0.0499419797295 | 0.5 | BRCA1 | BRCA1-SMAD3 complex |
| CORUM:2811 | 0.0499419797295 | 0.5 | BRCA1 | BRCA1-cABL complex |
| CORUM:2776 | 0.0499419797295 | 0.5 | BRCA1 | RAD50-BRCA1 complex |
| CORUM:5288 | 0.0499419797295 | 0.5 | BARD1 | P53-BARD1-KU70 complex |
| CORUM:242 | 0.0499419797295 | 0.5 | BRCA1 | BRCA1-BACH1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BARD1 | BRCA1 | 0.992 | 0.466207435897 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
Related Complexes
| Genename | Complexes |
|---|---|
| BRCA1 | huMAP3_00528.1 huMAP3_02895.1 huMAP3_12973.1 |
| BARD1 | huMAP3_00138.1 huMAP3_00528.1 huMAP3_02895.1 huMAP3_10261.1 huMAP3_14038.1 |