hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00532.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GPC6 | Glypican-6 [Cleaved into: Secreted glypican-6] | 5 | UniProt NCBI |
| GPC4 | Glypican-4 (K-glypican) [Cleaved into: Secreted glypican-4] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3656237 | 0.000155497319444 | 1.0 | GPC6 GPC4 | Defective EXT2 causes exostoses 2 |
| REAC:R-HSA-3656253 | 0.000155497319444 | 1.0 | GPC6 GPC4 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| REAC:R-HSA-9694614 | 0.00023239159829 | 1.0 | GPC6 GPC4 | Attachment and Entry |
| REAC:R-HSA-3560783 | 0.000261440548076 | 1.0 | GPC6 GPC4 | Defective B4GALT7 causes EDS, progeroid type |
| REAC:R-HSA-4420332 | 0.000261440548076 | 1.0 | GPC6 GPC4 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| REAC:R-HSA-3560801 | 0.000261440548076 | 1.0 | GPC6 GPC4 | Defective B3GAT3 causes JDSSDHD |
| REAC:R-HSA-2024096 | 0.000394723964742 | 1.0 | GPC6 GPC4 | HS-GAG degradation |
| REAC:R-HSA-1971475 | 0.000471618243588 | 1.0 | GPC6 GPC4 | A tetrasaccharide linker sequence is required for GAG synthesis |
| REAC:R-HSA-2022928 | 0.000645911942305 | 1.0 | GPC6 GPC4 | HS-GAG biosynthesis |
| REAC:R-HSA-9772572 | 0.000902226205124 | 1.0 | GPC6 GPC4 | Early SARS-CoV-2 Infection Events |
| REAC:R-HSA-3560782 | 0.00120125951175 | 1.0 | GPC6 GPC4 | Diseases associated with glycosaminoglycan metabolism |
| REAC:R-HSA-975634 | 0.00133283416666 | 1.0 | GPC6 GPC4 | Retinoid metabolism and transport |
| REAC:R-HSA-6806667 | 0.00154301186217 | 1.0 | GPC6 GPC4 | Metabolism of fat-soluble vitamins |
| REAC:R-HSA-1793185 | 0.00176856841345 | 1.0 | GPC6 GPC4 | Chondroitin sulfate/dermatan sulfate metabolism |
| REAC:R-HSA-1638091 | 0.00209323314636 | 1.0 | GPC6 GPC4 | Heparan sulfate/heparin (HS-GAG) metabolism |
| GO:0098696 | 0.00468200720083 | 1.0 | GPC6 GPC4 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
| REAC:R-HSA-2187338 | 0.00513141154164 | 1.0 | GPC6 GPC4 | Visual phototransduction |
| GO:0099633 | 0.00702301080125 | 1.0 | GPC6 GPC4 | protein localization to postsynaptic specialization membrane |
| GO:0099645 | 0.00702301080125 | 1.0 | GPC6 GPC4 | neurotransmitter receptor localization to postsynaptic specialization membrane |
| REAC:R-HSA-1630316 | 0.010244026704 | 1.0 | GPC6 GPC4 | Glycosaminoglycan metabolism |
| REAC:R-HSA-3781865 | 0.0106216630512 | 1.0 | GPC6 GPC4 | Diseases of glycosylation |
| REAC:R-HSA-196854 | 0.0209254964166 | 1.0 | GPC6 GPC4 | Metabolism of vitamins and cofactors |
| GO:1902683 | 0.0210690324038 | 1.0 | GPC6 GPC4 | regulation of receptor localization to synapse |
| HP:0005622 | 0.0277776310426 | 1.0 | GPC6 GPC4 | Broad long bones |
| REAC:R-HSA-5668914 | 0.0297170756313 | 1.0 | GPC6 GPC4 | Diseases of metabolism |
| GO:1902473 | 0.0309012475255 | 1.0 | GPC6 GPC4 | regulation of protein localization to synapse |
| REAC:R-HSA-9709957 | 0.0367862229998 | 1.0 | GPC6 GPC4 | Sensory Perception |
| GO:1903539 | 0.0426062655276 | 1.0 | GPC6 GPC4 | protein localization to postsynaptic membrane |
| GO:0062237 | 0.0426062655276 | 1.0 | GPC6 GPC4 | protein localization to postsynapse |
| HP:0005050 | 0.0499436884913 | 0.5 | GPC6 | Anterolateral radial head dislocation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GPC6 | GPC4 | 0.97 | 0.146 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes