hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00550.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
| AHCYL1 | S-adenosylhomocysteine hydrolase-like protein 1 (DC-expressed AHCY-like molecule) (IP(3)Rs binding protein released with IP(3)) (IRBIT) (Putative adenosylhomocysteinase 2) (S-adenosyl-L-homocysteine hydrolase 2) (AdoHcyase 2) | 5 | UniProt NCBI |
| CHD9 | Chromodomain-helicase-DNA-binding protein 9 (CHD-9) (EC 3.6.4.12) (ATP-dependent helicase CHD9) (Chromatin-related mesenchymal modulator) (CReMM) (Chromatin-remodeling factor CHROM1) (Kismet homolog 2) (PPAR-alpha-interacting complex protein 320 kDa) (Peroxisomal proliferator-activated receptor A-interacting complex 320 kDa protein) | 5 | UniProt NCBI |
| PLCD3 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5411 | 1.3807096837e-05 | 0.6 | PLCD3 PIP4K2A PIP4K2B | Phosphatidyl inositol phosphate pathway |
| WP:WP4971 | 1.3807096837e-05 | 0.6 | PLCD3 PIP4K2A PIP4K2B | Phosphoinositides metabolism |
| KEGG:00562 | 4.05033588721e-05 | 0.6 | PLCD3 PIP4K2A PIP4K2B | Inositol phosphate metabolism |
| REAC:R-HSA-8847453 | 9.11829675208e-05 | 0.4 | PIP4K2A PIP4K2B | Synthesis of PIPs in the nucleus |
| KEGG:04070 | 9.13984227268e-05 | 0.6 | PLCD3 PIP4K2A PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-6811555 | 0.000546723465219 | 0.4 | PIP4K2A PIP4K2B | PI5P Regulates TP53 Acetylation |
| REAC:R-HSA-1430728 | 0.00423241276191 | 1.0 | PLCD3 PIP4K2A CHD9 AHCYL1 PIP4K2B | Metabolism |
| REAC:R-HSA-6804758 | 0.0065872694687 | 0.4 | PIP4K2A PIP4K2B | Regulation of TP53 Activity through Acetylation |
| REAC:R-HSA-9006925 | 0.00931456721467 | 0.6 | PIP4K2A AHCYL1 PIP4K2B | Intracellular signaling by second messengers |
| KEGG:01100 | 0.0139298332568 | 0.8 | PLCD3 PIP4K2A AHCYL1 PIP4K2B | Metabolic pathways |
| GO:0016309 | 0.0140440992017 | 0.4 | PIP4K2A PIP4K2B | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902635 | 0.0140440992017 | 0.4 | PIP4K2A PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| GO:1902633 | 0.0140440992017 | 0.4 | PIP4K2A PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| REAC:R-HSA-1660499 | 0.0163316506439 | 0.4 | PIP4K2A PIP4K2B | Synthesis of PIPs at the plasma membrane |
| REAC:R-HSA-1483255 | 0.0384836492499 | 0.4 | PIP4K2A PIP4K2B | PI Metabolism |
| REAC:R-HSA-6811558 | 0.0406556405791 | 0.4 | PIP4K2A PIP4K2B | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| WP:WP51 | 0.046989062869 | 0.4 | PIP4K2A PIP4K2B | Regulation of actin cytoskeleton |
| REAC:R-HSA-199418 | 0.0487218825663 | 0.4 | PIP4K2A PIP4K2B | Negative regulation of the PI3K/AKT network |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| PIP4K2A | PLCD3 | 0.999 | 0.068 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PIP4K2A | AHCYL1 | 0.974 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| CHD9 | PIP4K2A | 0.972 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| AHCYL1 | PLCD3 | 0.951 | 0.082 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2B | PLCD3 | 0.95 | 0.068 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| CHD9 | PLCD3 | 0.754 | 0.134 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| PIP4K2B | AHCYL1 | 0.552 | 0.042 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| CHD9 | AHCYL1 | 0.262 | 0.158 | bioplex_WMM bioplex3_WMM fraction |
| CHD9 | PIP4K2B | 0.127 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes