hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00556.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RBCK1 | RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3) | 5 | UniProt NCBI |
| SHFL | Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN) | 5 | UniProt NCBI |
| RNF31 | E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6178 | 1.02521027753e-05 | 0.666666666667 | RBCK1 RNF31 | LUBAC complex |
| CORUM:6344 | 0.000310824382464 | 0.666666666667 | RBCK1 RNF31 | TNF-R1-associated signaling complex |
| REAC:R-HSA-5357786 | 0.00188000535098 | 0.666666666667 | RBCK1 RNF31 | TNFR1-induced proapoptotic signaling |
| REAC:R-HSA-5357956 | 0.0033773260227 | 0.666666666667 | RBCK1 RNF31 | TNFR1-induced NF-kappa-B signaling pathway |
| GO:0071797 | 0.00421361424067 | 0.666666666667 | RBCK1 RNF31 | LUBAC complex |
| REAC:R-HSA-5357905 | 0.00643790104829 | 0.666666666667 | RBCK1 RNF31 | Regulation of TNFR1 signaling |
| KEGG:04217 | 0.00706776241177 | 0.666666666667 | RBCK1 RNF31 | Necroptosis |
| KEGG:04621 | 0.00802719593767 | 0.666666666667 | RBCK1 RNF31 | NOD-like receptor signaling pathway |
| REAC:R-HSA-75893 | 0.00937397262456 | 0.666666666667 | RBCK1 RNF31 | TNF signaling |
| GO:0097039 | 0.0140440992017 | 0.666666666667 | RBCK1 RNF31 | protein linear polyubiquitination |
| KEGG:05131 | 0.0193802248568 | 0.666666666667 | RBCK1 RNF31 | Shigellosis |
| CORUM:7563 | 0.0499402709677 | 0.333333333333 | SHFL | LARP1-PABPC1-RYDEN complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| RBCK1 | RNF31 | 1.0 | 0.276 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| RBCK1 | SHFL | 0.987 | 0.074 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| SHFL | RNF31 | 0.954 | 0.056 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes