hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00560.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GAGE2D | G antigen 2D (GAGE-2D) (Cancer/testis antigen 4.8) (CT4.8) (G antigen 8) (GAGE-8) | 2 | UniProt NCBI |
| ZNF644 | Zinc finger protein 644 (Zinc finger motif enhancer-binding protein 2) (Zep-2) | 5 | UniProt NCBI |
| XAGE3 | X antigen family member 3 (XAGE-3) (Cancer/testis antigen 12.3) (CT12.3) (G antigen family D member 4) (Placenta-specific gene 6 protein) | 3 | UniProt NCBI |
| ZNF462 | Zinc finger protein 462 (Zinc finger PBX1-interacting protein) (ZFPIP) | 5 | UniProt NCBI |
| EHMT2 | Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a) | 5 | UniProt NCBI |
| EHMT1 | Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:643 | 0.000490935356523 | 0.4 | EHMT1 EHMT2 | CtBP core complex |
| CORUM:1194 | 0.000899678549321 | 0.4 | EHMT1 EHMT2 | E2F-6 complex |
| WP:WP4288 | 0.00100346979189 | 0.4 | EHMT1 EHMT2 | MTHFR deficiency |
| CORUM:642 | 0.00185261424459 | 0.4 | EHMT1 EHMT2 | CtBP complex |
| REAC:R-HSA-6804760 | 0.00232071308473 | 0.4 | EHMT1 EHMT2 | Regulation of TP53 Activity through Methylation |
| KEGG:00310 | 0.0074565122263 | 0.4 | EHMT1 EHMT2 | Lysine degradation |
| REAC:R-HSA-8953750 | 0.00849065158197 | 0.4 | EHMT1 EHMT2 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-8853884 | 0.0100756681589 | 0.4 | EHMT1 EHMT2 | Transcriptional Regulation by VENTX |
| WP:WP2369 | 0.0110316461811 | 0.4 | EHMT1 EHMT2 | Histone modifications |
| GO:0001222 | 0.0135806930791 | 0.6 | ZNF644 EHMT2 EHMT1 | transcription corepressor binding |
| KEGG:04211 | 0.0145692619713 | 0.4 | EHMT1 EHMT2 | Longevity regulating pathway |
| GO:0018027 | 0.0280843539964 | 0.4 | EHMT1 EHMT2 | peptidyl-lysine dimethylation |
| REAC:R-HSA-3214841 | 0.0343168520054 | 0.4 | EHMT1 EHMT2 | PKMTs methylate histone lysines |
| CORUM:860 | 0.0498708842806 | 0.2 | EHMT2 | DNMT1-EHMT2-PCNA complex |
| CORUM:862 | 0.0498708842806 | 0.2 | EHMT2 | DNMT1-EHMT2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ZNF644 | EHMT2 | 1.0 | 0.104 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| ZNF644 | EHMT1 | 0.999 | 0.194 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| XAGE3 | EHMT1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| XAGE3 | EHMT2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| EHMT2 | EHMT1 | 0.998 | 0.708 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ZNF644 | XAGE3 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZNF462 | EHMT2 | 0.988 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ZNF462 | EHMT1 | 0.985 | 0.132 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EHMT1 | GAGE2D | 0.967 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| EHMT2 | GAGE2D | 0.959 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ZNF644 | ZNF462 | 0.954 | 0.112 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ZNF644 | GAGE2D | 0.914 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes