hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00564.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1 | 5 | UniProt NCBI |
| SETD1B | Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B) | 5 | UniProt NCBI |
| KMT2A | Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)] | 5 | UniProt NCBI |
| HCFC2 | Host cell factor 2 (HCF-2) (C2 factor) | 5 | UniProt NCBI |
| KDM6A | Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A) | 5 | UniProt NCBI |
| HCFC1 | Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6] | 5 | UniProt NCBI |
| DPY30 | Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L) | 5 | UniProt NCBI |
| RBBP5 | Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3) | 5 | UniProt NCBI |
| KMT2C | Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3) | 5 | UniProt NCBI |
| BOD1 | Biorientation of chromosomes in cell division protein 1 (Biorientation defective protein 1) (Protein FAM44B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9772755 | 1.67623131597e-24 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | Formation of WDR5-containing histone-modifying complexes |
| GO:0035097 | 6.20037816184e-20 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | histone methyltransferase complex |
| CORUM:6470 | 2.4561704113e-19 | 0.7 | HCFC2 SETD1B BOD1 DPY30 HCFC1 RBBP5 BOD1L1 | Set1B complex |
| GO:0034708 | 2.6307752246e-18 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | methyltransferase complex |
| REAC:R-HSA-212165 | 8.90932794645e-18 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | Epigenetic regulation of gene expression |
| GO:0048188 | 7.28811167197e-16 | 0.7 | HCFC2 SETD1B BOD1 DPY30 HCFC1 RBBP5 BOD1L1 | Set1C/COMPASS complex |
| CORUM:6462 | 5.63923523184e-10 | 0.4 | KMT2A DPY30 RBBP5 HCFC1 | MLL1 complex |
| CORUM:6461 | 1.01472881603e-09 | 0.4 | KDM6A RBBP5 KMT2C DPY30 | MLL3 complex |
| CORUM:6469 | 1.69065897579e-09 | 0.4 | HCFC2 DPY30 RBBP5 HCFC1 | Set1A complex |
| CORUM:6460 | 1.69065897579e-09 | 0.4 | HCFC2 DPY30 RBBP5 HCFC1 | MLL2 complex |
| CORUM:5195 | 1.69065897579e-09 | 0.4 | KDM6A RBBP5 KMT2C DPY30 | PTIP-HMT complex |
| REAC:R-HSA-74160 | 7.08995943957e-09 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | Gene expression (Transcription) |
| GO:1990234 | 8.53638831853e-09 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | transferase complex |
| REAC:R-HSA-3247509 | 1.09368514005e-08 | 0.7 | KDM6A KMT2C KMT2A SETD1B DPY30 HCFC1 RBBP5 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 1.09368514005e-08 | 0.7 | KDM6A KMT2C KMT2A SETD1B DPY30 HCFC1 RBBP5 | Chromatin organization |
| REAC:R-HSA-3214841 | 1.12229720487e-07 | 0.5 | SETD1B DPY30 KMT2C RBBP5 KMT2A | PKMTs methylate histone lysines |
| CORUM:6851 | 1.68264493604e-07 | 0.3 | KMT2A RBBP5 DPY30 | MWRAD complex (MLL1, WDR5, RBBP5, ASH2L, DPY30) |
| WP:WP5351 | 2.56231464612e-07 | 0.4 | KDM6A RBBP5 KMT2C DPY30 | Kleefstra syndrome |
| REAC:R-HSA-8936459 | 2.57935569353e-07 | 0.5 | SETD1B DPY30 KMT2C RBBP5 KMT2A | RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function |
| GO:0140513 | 2.96585252242e-07 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | nuclear protein-containing complex |
| GO:0071339 | 3.82695699598e-07 | 0.5 | RBBP5 KMT2A HCFC1 DPY30 HCFC2 | MLL1 complex |
| GO:0044665 | 4.53435749979e-07 | 0.5 | RBBP5 KMT2A HCFC1 DPY30 HCFC2 | MLL1/2 complex |
| CORUM:1256 | 5.88502576438e-07 | 0.3 | KMT2A RBBP5 HCFC1 | MLL-HCF complex |
| CORUM:6467 | 1.41139128787e-06 | 0.3 | KDM6A RBBP5 DPY30 | MLL4 complex |
| GO:0044666 | 1.81927560642e-06 | 0.4 | KDM6A RBBP5 KMT2C DPY30 | MLL3/4 complex |
| CORUM:3075 | 3.69251717673e-06 | 0.3 | KDM6A KMT2C RBBP5 | UTX-MLL2/3 complex |
| GO:1902494 | 7.59864524954e-06 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | catalytic complex |
| REAC:R-HSA-8878171 | 3.43347437563e-05 | 0.5 | SETD1B DPY30 KMT2C RBBP5 KMT2A | Transcriptional regulation by RUNX1 |
| CORUM:5386 | 4.34197388115e-05 | 0.3 | KMT2A RBBP5 HCFC1 | MLL1-WDR5 complex |
| REAC:R-HSA-5617472 | 0.000128227342776 | 0.4 | KDM6A RBBP5 KMT2C DPY30 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| REAC:R-HSA-5619507 | 0.000128227342776 | 0.4 | KDM6A RBBP5 KMT2C DPY30 | Activation of HOX genes during differentiation |
| CORUM:6849 | 0.000184411585051 | 0.2 | DPY30 RBBP5 | WRAD complex (WDR5, RBBP5, ASH2L, DPY30) |
| CORUM:6457 | 0.000184411585051 | 0.2 | KMT2A RBBP5 | MLL1 core complex |
| KEGG:00310 | 0.000351394323482 | 0.3 | SETD1B KMT2C KMT2A | Lysine degradation |
| CORUM:2730 | 0.000460692494101 | 0.2 | SETD1B RBBP5 | Set1B complex |
| CORUM:1400 | 0.00064473409071 | 0.2 | RBBP5 KMT2C | ASCOM complex |
| CORUM:1254 | 0.00064473409071 | 0.2 | DPY30 RBBP5 | Menin-associated histone methyltransferase complex |
| WP:WP2369 | 0.000840691822993 | 0.3 | SETD1B KMT2C KMT2A | Histone modifications |
| CORUM:1401 | 0.00138006084651 | 0.2 | KMT2A RBBP5 | MOF complex |
| GO:0042800 | 0.0018977127037 | 0.3 | SETD1B KMT2C KMT2A | histone H3K4 methyltransferase activity |
| GO:0006338 | 0.00370518243096 | 0.6 | KDM6A KMT2A HCFC1 DPY30 HCFC2 RBBP5 | chromatin remodeling |
| HP:0007655 | 0.0061877325188 | 0.2 | KMT2A KDM6A | Eversion of lateral third of lower eyelids |
| GO:0006325 | 0.0083213397889 | 0.6 | KDM6A KMT2A HCFC1 DPY30 HCFC2 RBBP5 | chromatin organization |
| CORUM:1257 | 0.0115165829929 | 0.2 | KMT2A RBBP5 | ALL-1 supercomplex |
| GO:0071824 | 0.0198344237125 | 0.6 | KDM6A KMT2A HCFC1 DPY30 HCFC2 RBBP5 | protein-DNA complex organization |
| REAC:R-HSA-1266738 | 0.032020162516 | 0.5 | KMT2A DPY30 KMT2C RBBP5 KDM6A | Developmental Biology |
| GO:0005654 | 0.042696914045 | 1.0 | KDM6A RBBP5 KMT2C DPY30 HCFC1 BOD1 KMT2A SETD1B HCFC2 BOD1L1 | nucleoplasm |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SETD1B | RBBP5 | 1.0 | 0.106 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| KMT2A | HCFC2 | 1.0 | 0.144 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| HCFC2 | HCFC1 | 0.999 | 0.196 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| BOD1L1 | HCFC2 | 0.999 | 0.188 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| KMT2A | RBBP5 | 0.999 | 0.156 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| BOD1L1 | RBBP5 | 0.999 | 0.324 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116 |
| RBBP5 | BOD1 | 0.998 | 0.134 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () |
| DPY30 | RBBP5 | 0.998 | 0.466 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| SETD1B | BOD1 | 0.996 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM hein () |
| HCFC2 | RBBP5 | 0.996 | 0.348 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BOD1L1 | HCFC1 | 0.993 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| KDM6A | RBBP5 | 0.993 | 0.316 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
| HCFC1 | RBBP5 | 0.989 | 0.068 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| BOD1L1 | KDM6A | 0.98 | 0.15 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SETD1B | KDM6A | 0.976 | 0.28 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| KMT2A | KDM6A | 0.976 | 0.284 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| RBBP5 | KMT2C | 0.972 | 0.094 | bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only |
| BOD1L1 | BOD1 | 0.955 | 0.132 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| BOD1L1 | KMT2A | 0.947 | 0.18 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SETD1B | KMT2A | 0.946 | 0.222 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| HCFC2 | DPY30 | 0.945 | 0.34 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| BOD1L1 | SETD1B | 0.945 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SETD1B | HCFC1 | 0.94 | 0.14 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| KDM6A | HCFC1 | 0.853 | 0.12 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SETD1B | HCFC2 | 0.842 | 0.154 | bioplex_WMM bioplex3_WMM WMM_only |
| KMT2A | HCFC1 | 0.825 | 0.09 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| KDM6A | DPY30 | 0.824 | 0.212 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| KDM6A | BOD1 | 0.798 | 0.152 | bioplex_WMM bioplex3_WMM WMM_only |
| HCFC2 | KDM6A | 0.769 | 0.22 | bioplex_WMM bioplex3_WMM WMM_only |
| HCFC1 | BOD1 | 0.705 | 0.226 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| DPY30 | BOD1 | 0.673 | 0.104 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| BOD1L1 | DPY30 | 0.499 | 0.362 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| SETD1B | DPY30 | 0.452 | 0.212 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| KMT2A | BOD1 | 0.373 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
| KMT2A | DPY30 | 0.362 | 0.078 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| HCFC2 | BOD1 | 0.276 | 0.236 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| KDM6A | KMT2C | 0.266 | 0.166 | bioplex3_WMM youn_WMM WMM_only |
| HCFC1 | DPY30 | 0.193 | 0.164 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction |
| HCFC2 | KMT2C | 0.082 | 0.112 | bioplex3_WMM WMM_only |
| KMT2C | BOD1 | 0.079 | 0.096 | bioplex3_WMM WMM_only |
| SETD1B | KMT2C | 0.079 | 0.104 | bioplex3_WMM WMM_only |
| BOD1L1 | KMT2C | 0.079 | 0.096 | bioplex3_WMM WMM_only |
| DPY30 | KMT2C | 0.078 | 0.1 | bioplex3_WMM youn_WMM WMM_only |
| KMT2A | KMT2C | 0.071 | 0.07 | bioplex3_WMM youn_WMM WMM_only |
| HCFC1 | KMT2C | 0.024 | 0.19 | bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes