hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00597.1
Complex Portal: CPX-7978
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TBP | TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit) | 5 | UniProt NCBI |
| TAF1A | TATA box-binding protein-associated factor RNA polymerase I subunit A (RNA polymerase I-specific TBP-associated factor 48 kDa) (TAFI48) (TATA box-binding protein-associated factor 1A) (TBP-associated factor 1A) (Transcription factor SL1) (Transcription initiation factor SL1/TIF-IB subunit A) | 5 | UniProt NCBI |
| TAF1C | TATA box-binding protein-associated factor RNA polymerase I subunit C (RNA polymerase I-specific TBP-associated factor 110 kDa) (TAFI110) (TATA box-binding protein-associated factor 1C) (TBP-associated factor 1C) (Transcription initiation factor SL1/TIF-IB subunit C) | 5 | UniProt NCBI |
| TAF1D | TATA box-binding protein-associated factor RNA polymerase I subunit D (RNA polymerase I-specific TBP-associated factor 41 kDa) (TAFI41) (TATA box-binding protein-associated factor 1D) (TBP-associated factor 1D) (Transcription initiation factor SL1/TIF-IB subunit D) | 5 | UniProt NCBI |
| TAF1B | TATA box-binding protein-associated factor RNA polymerase I subunit B (RNA polymerase I-specific TBP-associated factor 63 kDa) (TAFI63) (TATA box-binding protein-associated factor 1B) (TBP-associated factor 1B) (Transcription initiation factor SL1/TIF-IB subunit B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5727 | 3.83566049696e-13 | 0.8 | TAF1C TAF1B TBP TAF1A | TBP-TAF complex |
| REAC:R-HSA-73863 | 4.9673540832e-12 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | RNA Polymerase I Transcription Termination |
| REAC:R-HSA-73762 | 4.48447608162e-11 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | RNA Polymerase I Transcription Initiation |
| REAC:R-HSA-427359 | 1.11672455607e-10 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | SIRT1 negatively regulates rRNA expression |
| REAC:R-HSA-5250924 | 6.17183461414e-10 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | B-WICH complex positively regulates rRNA expression |
| REAC:R-HSA-73772 | 6.58885046645e-10 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | RNA Polymerase I Promoter Escape |
| REAC:R-HSA-5250913 | 1.5193822932e-09 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | Positive epigenetic regulation of rRNA expression |
| REAC:R-HSA-427413 | 1.60474084899e-09 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | NoRC negatively regulates rRNA expression |
| REAC:R-HSA-5250941 | 1.88408178672e-09 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | Negative epigenetic regulation of rRNA expression |
| REAC:R-HSA-73854 | 1.98537650643e-09 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | RNA Polymerase I Promoter Clearance |
| REAC:R-HSA-73864 | 2.09098163975e-09 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | RNA Polymerase I Transcription |
| REAC:R-HSA-212165 | 3.35799361333e-08 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | Epigenetic regulation of gene expression |
| REAC:R-HSA-74160 | 0.000887298860527 | 1.0 | TAF1C TAF1B TBP TAF1D TAF1A | Gene expression (Transcription) |
| GO:0001046 | 0.00475337188383 | 0.6 | TAF1B TBP TAF1C | core promoter sequence-specific DNA binding |
| GO:0006360 | 0.0294915925302 | 0.6 | TAF1B TAF1A TAF1C | transcription by RNA polymerase I |
| CORUM:721 | 0.0498708842806 | 0.2 | TBP | PU.1-TBP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TAF1A | TAF1C | 0.998 | 0.178 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| TAF1D | TAF1B | 0.998 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TAF1A | TAF1B | 0.997 | 0.178 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| TAF1A | TAF1D | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM | ||
| TAF1C | TAF1B | 0.996 | 0.15 |
mutually_exclusive (Q15573)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM |
| TAF1C | TAF1D | 0.995 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| TBP | TAF1D | 0.993 |
mutually_exclusive (Q15572)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBP | TAF1A | 0.848 | 0.218 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TBP | TAF1B | 0.505 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| TBP | TAF1C | 0.383 | 0.12 |
mutually_exclusive (Q15573)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM WMM_only |
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