hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00604.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| UGT1A10 | UDP-glucuronosyltransferase 1A10 (UGT1A10) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-10) (UDPGT 1-10) (UGT1*10) (UGT1-10) (UGT1.10) (UDP-glucuronosyltransferase 1-J) (UGT-1J) (UGT1J) | 5 | UniProt NCBI |
| UGT1A8 | UDP-glucuronosyltransferase 1A8 (UGT1A8) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-8) (UDPGT 1-8) (UGT1*8) (UGT1-08) (UGT1.8) (UDP-glucuronosyltransferase 1-H) (UGT-1H) (UGT1H) | 5 | UniProt NCBI |
| UGT1A7 | UDP-glucuronosyltransferase 1A7 (UGT1A7) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-7) (UDPGT 1-7) (UGT1*7) (UGT1-07) (UGT1.7) (UDP-glucuronosyltransferase 1-G) (UGT-1G) (UGT1G) | 5 | UniProt NCBI |
| UGT1A9 | UDP-glucuronosyltransferase 1A9 (UGT1A9) (EC 2.4.1.17) (UDP-glucuronosyltransferase 1-9) (UDPGT 1-9) (UGT1*9) (UGT1-09) (UGT1.9) (UDP-glucuronosyltransferase 1-I) (UGT-1I) (UGT1I) (lugP4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0051552 | 2.63126310092e-11 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | flavone metabolic process |
| WP:WP698 | 7.31969553527e-11 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Glucuronidation |
| KEGG:00053 | 1.71854371279e-10 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Ascorbate and aldarate metabolism |
| REAC:R-HSA-156588 | 1.74777330061e-10 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Glucuronidation |
| KEGG:00040 | 2.9719176988e-10 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Pentose and glucuronate interconversions |
| GO:0009812 | 9.2094208532e-10 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | flavonoid metabolic process |
| KEGG:00860 | 9.61350768656e-10 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Porphyrin metabolism |
| KEGG:00140 | 2.14706370351e-09 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Steroid hormone biosynthesis |
| KEGG:00830 | 5.87100579392e-09 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Retinol metabolism |
| KEGG:05204 | 6.87946087076e-09 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Chemical carcinogenesis - DNA adducts |
| KEGG:00982 | 7.42981774043e-09 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Drug metabolism - cytochrome P450 |
| KEGG:04976 | 9.96755353416e-09 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Bile secretion |
| KEGG:00980 | 1.06924665185e-08 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Metabolism of xenobiotics by cytochrome P450 |
| KEGG:00983 | 1.80072369785e-08 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Drug metabolism - other enzymes |
| GO:0052695 | 2.63389436402e-08 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | cellular glucuronidation |
| GO:0006063 | 3.59167413275e-08 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | uronic acid metabolic process |
| GO:0019585 | 3.59167413275e-08 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | glucuronate metabolic process |
| WP:WP1604 | 4.19282206901e-08 | 0.75 | UGT1A8 UGT1A10 UGT1A9 | Codeine and morphine metabolism |
| WP:WP5224 | 1.14345843754e-07 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | 2q37 copy number variation syndrome |
| REAC:R-HSA-156580 | 1.51881499823e-07 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Phase II - Conjugation of compounds |
| REAC:R-HSA-9748784 | 1.59771447866e-07 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Drug ADME |
| GO:0015020 | 2.79598017103e-07 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | glucuronosyltransferase activity |
| KEGG:01240 | 3.01673163342e-07 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Biosynthesis of cofactors |
| KEGG:05207 | 6.6586086216e-07 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Chemical carcinogenesis - receptor activation |
| GO:0052696 | 1.53784171933e-06 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | flavonoid glucuronidation |
| GO:0001889 | 1.737817715e-06 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | liver development |
| GO:0061008 | 1.94226685794e-06 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | hepaticobiliary system development |
| REAC:R-HSA-211859 | 2.72176702781e-06 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Biological oxidations |
| REAC:R-HSA-9749641 | 5.68914662089e-06 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | Aspirin ADME |
| GO:0042440 | 6.57552648919e-06 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | pigment metabolic process |
| GO:0052697 | 7.68841921772e-06 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | xenobiotic glucuronidation |
| GO:0006805 | 5.85691538001e-05 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | xenobiotic metabolic process |
| GO:0001972 | 0.000109904886398 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | retinoic acid binding |
| WP:WP702 | 0.000139209137611 | 0.75 | UGT1A7 UGT1A10 UGT1A9 | Metapathway biotransformation Phase I and II |
| WP:WP229 | 0.000140344895657 | 0.5 | UGT1A10 UGT1A9 | Irinotecan pathway |
| GO:0071466 | 0.000146383770774 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | cellular response to xenobiotic stimulus |
| GO:0048732 | 0.000169420189784 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | gland development |
| GO:0008194 | 0.000181908164461 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | UDP-glycosyltransferase activity |
| WP:WP691 | 0.000232143427839 | 0.5 | UGT1A8 UGT1A10 | Tamoxifen metabolism |
| GO:0009410 | 0.000415139510394 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | response to xenobiotic stimulus |
| GO:0005501 | 0.000510886175237 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | retinoid binding |
| GO:0019840 | 0.000510886175237 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | isoprenoid binding |
| WP:WP5276 | 0.000535373329556 | 0.5 | UGT1A8 UGT1A10 | Estrogen metabolism |
| GO:0016758 | 0.000640958193483 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | hexosyltransferase activity |
| GO:0046982 | 0.000862926049337 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | protein heterodimerization activity |
| GO:0042573 | 0.000883305813556 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | retinoic acid metabolic process |
| WP:WP2873 | 0.00169541860832 | 0.5 | UGT1A7 UGT1A9 | Aryl hydrocarbon receptor pathway |
| GO:0016757 | 0.00227782697336 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | glycosyltransferase activity |
| REAC:R-HSA-9753281 | 0.00236402400204 | 0.5 | UGT1A10 UGT1A9 | Paracetamol ADME |
| KEGG:01100 | 0.00275730008049 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Metabolic pathways |
| GO:0033293 | 0.0112187083505 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | monocarboxylic acid binding |
| GO:0001523 | 0.0112187083505 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | retinoid metabolic process |
| GO:0016101 | 0.0124631389739 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | diterpenoid metabolic process |
| WP:WP2884 | 0.015715675352 | 0.5 | UGT1A7 UGT1A9 | NRF2 pathway |
| GO:0006721 | 0.0183580179548 | 0.75 | UGT1A8 UGT1A9 UGT1A7 | terpenoid metabolic process |
| GO:0009698 | 0.0280843539964 | 0.5 | UGT1A8 UGT1A7 | phenylpropanoid metabolic process |
| GO:0009804 | 0.0280843539964 | 0.5 | UGT1A8 UGT1A7 | coumarin metabolic process |
| GO:0032787 | 0.0317425976647 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | monocarboxylic acid metabolic process |
| WP:WP1600 | 0.0373138951921 | 0.25 | UGT1A9 | Nicotine metabolism in liver cells |
| REAC:R-HSA-1430728 | 0.0393174957935 | 1.0 | UGT1A8 UGT1A9 UGT1A10 UGT1A7 | Metabolism |
| WP:WP694 | 0.049746753544 | 0.25 | UGT1A9 | Arylamine metabolism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| UGT1A7 | UGT1A10 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UGT1A7 | UGT1A9 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| UGT1A10 | UGT1A9 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UGT1A8 | UGT1A7 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A9 | 0.415 | bioplex3_WMM WMM_only | |
| UGT1A8 | UGT1A10 | 0.415 | bioplex3_WMM WMM_only |
Related Complexes