hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00633.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASP3 | Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12] | 5 | UniProt NCBI |
| CASP7 | Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11] | 5 | UniProt NCBI |
| MORN3 | MORN repeat-containing protein 3 | 5 | UniProt NCBI |
| XIAP | E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111459 | 1.40306823124e-08 | 0.75 | CASP3 XIAP CASP7 | Activation of caspases through apoptosome-mediated cleavage |
| REAC:R-HSA-111469 | 2.80599241523e-08 | 0.75 | CASP3 XIAP CASP7 | SMAC, XIAP-regulated apoptotic response |
| REAC:R-HSA-111464 | 2.80599241523e-08 | 0.75 | CASP3 XIAP CASP7 | SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes |
| REAC:R-HSA-111463 | 2.80599241523e-08 | 0.75 | CASP3 XIAP CASP7 | SMAC (DIABLO) binds to IAPs |
| REAC:R-HSA-111461 | 3.0856409449e-07 | 0.75 | CASP3 XIAP CASP7 | Cytochrome c-mediated apoptotic response |
| REAC:R-HSA-111471 | 9.53498684462e-07 | 0.75 | CASP3 XIAP CASP7 | Apoptotic factor-mediated response |
| KEGG:04215 | 1.25269255935e-06 | 0.75 | CASP3 XIAP CASP7 | Apoptosis - multiple species |
| WP:WP254 | 2.16610999348e-05 | 0.75 | CASP3 XIAP CASP7 | Apoptosis |
| WP:WP1772 | 2.64882854506e-05 | 0.75 | CASP3 XIAP CASP7 | Apoptosis modulation and signaling |
| REAC:R-HSA-109606 | 3.0932996971e-05 | 0.75 | CASP3 XIAP CASP7 | Intrinsic Pathway for Apoptosis |
| WP:WP5090 | 3.95185168793e-05 | 0.75 | CASP3 XIAP CASP7 | Complement system in neuronal development and plasticity |
| KEGG:04668 | 4.7291535364e-05 | 0.75 | CASP3 XIAP CASP7 | TNF signaling pathway |
| KEGG:04210 | 9.58294361569e-05 | 0.75 | CASP3 XIAP CASP7 | Apoptosis |
| WP:WP3853 | 0.000114838123418 | 0.5 | CASP3 CASP7 | ERK pathway in Huntington 39 s disease |
| WP:WP5182 | 0.000232143427839 | 0.5 | CASP3 CASP7 | Pro survival signaling of neuroprotectin D1 |
| WP:WP384 | 0.000346844620397 | 0.5 | CASP3 CASP7 | Apoptosis modulation by HSP70 |
| WP:WP2507 | 0.000436026474737 | 0.5 | CASP3 CASP7 | Nanomaterial induced apoptosis |
| WP:WP4864 | 0.000484429625977 | 0.5 | CASP3 CASP7 | Host pathogen interaction of human coronaviruses apoptosis |
| REAC:R-HSA-264870 | 0.000563428413222 | 0.5 | CASP3 CASP7 | Caspase-mediated cleavage of cytoskeletal proteins |
| WP:WP1433 | 0.000828175715845 | 0.5 | CASP7 XIAP | Nucleotide binding oligomerization domain NOD pathway |
| REAC:R-HSA-109581 | 0.00104173974765 | 0.75 | CASP3 XIAP CASP7 | Apoptosis |
| WP:WP2371 | 0.00142851438729 | 0.5 | CASP3 CASP7 | Parkinson 39 s disease pathway |
| WP:WP2036 | 0.00160392090455 | 0.5 | CASP3 CASP7 | TNF related weak inducer of apoptosis TWEAK signaling pathway |
| REAC:R-HSA-5357801 | 0.00166476808943 | 0.75 | CASP3 XIAP CASP7 | Programmed Cell Death |
| WP:WP314 | 0.00178944501344 | 0.5 | CASP3 CASP7 | Fas ligand pathway and stress induction of heat shock proteins |
| WP:WP3646 | 0.002190823719 | 0.5 | CASP3 CASP7 | Hepatitis C and hepatocellular carcinoma |
| WP:WP3286 | 0.002406667175 | 0.5 | CASP3 XIAP | Copper homeostasis |
| KEGG:05134 | 0.00281740883519 | 0.5 | CASP3 CASP7 | Legionellosis |
| WP:WP2374 | 0.0035028118218 | 0.5 | CASP3 CASP7 | Oncostatin M signaling pathway |
| KEGG:05133 | 0.00426927356048 | 0.5 | CASP3 CASP7 | Pertussis |
| KEGG:05200 | 0.0049271234807 | 0.75 | CASP3 XIAP CASP7 | Pathways in cancer |
| WP:WP2328 | 0.00561306746582 | 0.5 | CASP3 CASP7 | Allograft rejection |
| KEGG:04623 | 0.00601982850302 | 0.5 | CASP3 CASP7 | Cytosolic DNA-sensing pathway |
| KEGG:01524 | 0.00601982850302 | 0.5 | CASP3 XIAP | Platinum drug resistance |
| REAC:R-HSA-111465 | 0.006081926491 | 0.5 | CASP3 CASP7 | Apoptotic cleavage of cellular proteins |
| WP:WP4298 | 0.0063063631888 | 0.5 | CASP3 CASP7 | Acute viral myocarditis |
| GO:0072734 | 0.00842684400117 | 0.5 | CASP3 CASP7 | cellular response to staurosporine |
| GO:0072733 | 0.00842684400117 | 0.5 | CASP3 CASP7 | response to staurosporine |
| WP:WP231 | 0.00883615359641 | 0.5 | CASP3 CASP7 | TNF alpha signaling pathway |
| KEGG:05222 | 0.00909742323246 | 0.5 | CASP3 XIAP | Small cell lung cancer |
| KEGG:05145 | 0.0101879335017 | 0.5 | CASP3 XIAP | Toxoplasmosis |
| REAC:R-HSA-75153 | 0.0120053783973 | 0.5 | CASP3 CASP7 | Apoptotic execution phase |
| REAC:R-HSA-5218859 | 0.0140623832262 | 0.5 | CASP3 XIAP | Regulated Necrosis |
| KEGG:04148 | 0.0189154103852 | 0.5 | CASP3 CASP7 | Efferocytosis |
| WP:WP4396 | 0.023499356813 | 0.5 | CASP3 CASP7 | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.0237566589162 | 0.5 | CASP3 CASP7 | Non-alcoholic fatty liver disease |
| KEGG:05130 | 0.0334335704012 | 0.5 | CASP3 CASP7 | Pathogenic Escherichia coli infection |
| KEGG:05417 | 0.0397541089323 | 0.5 | CASP3 CASP7 | Lipid and atherosclerosis |
| GO:0097200 | 0.042122686785 | 0.5 | CASP3 CASP7 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| CORUM:6292 | 0.049938562206 | 0.25 | XIAP | HAX-1-XIAP complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CASP7 | XIAP | 0.987 | 0.21 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| CASP3 | XIAP | 0.979 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MORN3 | XIAP | 0.975 | bioplex3_WMM bioplex3_HCT116 WMM_only |
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