hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00659.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INA | Alpha-internexin (Alpha-Inx) (66 kDa neurofilament protein) (NF-66) (Neurofilament-66) (Neurofilament 5) | 5 | UniProt NCBI |
| NEFH | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein) | 5 | UniProt NCBI |
| NEFL | Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein) | 5 | UniProt NCBI |
| NEFM | Neurofilament medium polypeptide (NF-M) (160 kDa neurofilament protein) (Neurofilament 3) (Neurofilament triplet M protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0099160 | 9.61200410764e-08 | 1.0 | INA NEFM NEFL | postsynaptic intermediate filament cytoskeleton |
| GO:0099571 | 9.61200410764e-07 | 1.0 | INA NEFM NEFL | postsynaptic cytoskeleton |
| GO:0005883 | 5.38272230028e-06 | 1.0 | INA NEFM NEFL | neurofilament |
| WP:WP2447 | 0.000597242805422 | 0.666666666667 | NEFL NEFM | Amyotrophic lateral sclerosis ALS |
| GO:0045109 | 0.000810868666521 | 1.0 | INA NEFM NEFL | intermediate filament organization |
| WP:WP3680 | 0.00193308448658 | 0.666666666667 | NEFL NEFM | Physico chemical features and toxicity associated pathways |
| GO:0045104 | 0.00212425290779 | 1.0 | INA NEFM NEFL | intermediate filament cytoskeleton organization |
| GO:0045103 | 0.00225170808226 | 1.0 | INA NEFM NEFL | intermediate filament-based process |
| GO:0005882 | 0.00381702295119 | 1.0 | INA NEFM NEFL | intermediate filament |
| WP:WP5417 | 0.00412431213363 | 0.666666666667 | NEFL NEFM | Cell lineage map for neuronal differentiation |
| GO:0099184 | 0.00421361424067 | 0.666666666667 | INA NEFL | structural constituent of postsynaptic intermediate filament cytoskeleton |
| GO:0033693 | 0.00421361424067 | 0.666666666667 | NEFL NEFM | neurofilament bundle assembly |
| HPA:0091043 | 0.00593991336401 | 0.666666666667 | INA NEFM | cerebellum; processes in white matter[High] |
| HPA:0091033 | 0.00655950129524 | 0.666666666667 | INA NEFM | cerebellum; processes in molecular layer[High] |
| HPA:0091023 | 0.00806545886128 | 0.666666666667 | INA NEFM | cerebellum; processes in granular layer[High] |
| GO:0005200 | 0.0112921824257 | 1.0 | INA NEFM NEFL | structural constituent of cytoskeleton |
| GO:0045111 | 0.0124731132503 | 1.0 | INA NEFM NEFL | intermediate filament cytoskeleton |
| HPA:0091042 | 0.0195167913168 | 0.666666666667 | INA NEFM | cerebellum; processes in white matter[>=Medium] |
| HPA:0091022 | 0.0203444084371 | 0.666666666667 | INA NEFM | cerebellum; processes in granular layer[>=Medium] |
| HPA:0091032 | 0.0223418738472 | 0.666666666667 | INA NEFM | cerebellum; processes in molecular layer[>=Medium] |
| WP:WP4352 | 0.0243888015773 | 0.666666666667 | NEFL NEFM | Ciliary landscape |
| HPA:0091031 | 0.0253564028883 | 0.666666666667 | INA NEFM | cerebellum; processes in molecular layer[>=Low] |
| HPA:0091041 | 0.0262976640836 | 0.666666666667 | INA NEFM | cerebellum; processes in white matter[>=Low] |
| HPA:0091021 | 0.0275791520941 | 0.666666666667 | INA NEFM | cerebellum; processes in granular layer[>=Low] |
| GO:0045110 | 0.0393180950424 | 0.666666666667 | NEFL NEFM | intermediate filament bundle assembly |
| KEGG:05014 | 0.0393573532881 | 0.666666666667 | NEFL NEFM | Amyotrophic lateral sclerosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NEFL | NEFM | 0.999 | 0.236 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| INA | NEFM | 0.998 | 0.138 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM |
| NEFH | NEFM | 0.994 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| INA | NEFL | 0.861 | 0.158 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM |
| NEFH | NEFL | 0.72 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| INA | NEFH | 0.609 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes