hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00664.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GON7 | EKC/KEOPS complex subunit GON7 | 5 | UniProt NCBI |
| TP53RK | EKC/KEOPS complex subunit TP53RK (EC 3.6.-.-) (Atypical serine/threonine protein kinase TP53RK) (Nori-2) (TP53-regulating kinase) (EC 2.7.11.1) (p53-related protein kinase) | 5 | UniProt NCBI |
| TPRKB | EKC/KEOPS complex subunit TPRKB (PRPK-binding protein) (TP53RK-binding protein) | 5 | UniProt NCBI |
| HYKK | Hydroxylysine kinase (5-hydroxy-L-lysine kinase) (EC 2.7.1.81) (Aminoglycoside phosphotransferase domain-containing protein 1) | 5 | UniProt NCBI |
| PPIAL4C | Peptidyl-prolyl cis-trans isomerase A-like 4C (PPIase A-like 4C) (EC 5.2.1.8) | 2 | UniProt NCBI |
| OSGEP | tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP) | 5 | UniProt NCBI |
| LAGE3 | EKC/KEOPS complex subunit LAGE3 (L antigen family member 3) (Protein ESO-3) (Protein ITBA2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000408 | 1.89092208334e-13 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | EKC/KEOPS complex |
| CORUM:7555 | 1.92263483365e-12 | 0.571428571429 | TP53RK LAGE3 OSGEP TPRKB | KEOPS complex |
| HP:0100720 | 2.53629593061e-12 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Hypoplasia of the ear cartilage |
| HP:0002410 | 2.58086881764e-10 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Aqueductal stenosis |
| HP:0002036 | 6.43414181146e-10 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Hiatus hernia |
| HP:0005108 | 2.10047276274e-09 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal intervertebral disk morphology |
| GO:0070525 | 2.19525393622e-09 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | tRNA threonylcarbamoyladenosine metabolic process |
| HP:0000096 | 8.14056349469e-08 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Glomerular sclerosis |
| HP:0000112 | 8.66817837817e-08 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Nephropathy |
| REAC:R-HSA-6782315 | 2.34474893536e-07 | 0.571428571429 | TP53RK LAGE3 OSGEP TPRKB | tRNA modification in the nucleus and cytosol |
| HP:0001181 | 3.05952183934e-07 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Adducted thumb |
| HP:0000100 | 3.53068288016e-07 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Nephrotic syndrome |
| HP:0003774 | 5.07552653188e-07 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Stage 5 chronic kidney disease |
| HP:0000601 | 7.71955900414e-07 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Hypotelorism |
| HP:0001622 | 1.46474928031e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Premature birth |
| HP:0001302 | 1.80286634718e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Pachygyria |
| HP:0000095 | 2.75006492183e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal renal glomerulus morphology |
| HP:0031263 | 2.83676580611e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal renal corpuscle morphology |
| HP:0012622 | 3.11004320392e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Chronic kidney disease |
| HP:0001339 | 3.30361606843e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Lissencephaly |
| HP:0100490 | 3.94272730705e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Camptodactyly of finger |
| HP:0008772 | 4.80922540713e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Aplasia/Hypoplasia of the external ear |
| HP:0001220 | 5.08281463466e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Interphalangeal joint contracture of finger |
| HP:0000097 | 5.27912158282e-06 | 0.571428571429 | TP53RK LAGE3 GON7 TPRKB | Focal segmental glomerulosclerosis |
| HP:0008771 | 5.66725430433e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Aplasia/Hypoplasia of the ear |
| HP:0006261 | 6.81827216172e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal phalangeal joint morphology of the hand |
| HP:0011035 | 7.36534044878e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal renal cortex morphology |
| HP:0004374 | 7.74911121676e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Hemiplegia/hemiparesis |
| HP:0000093 | 7.74911121676e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Proteinuria |
| HP:0012785 | 8.99712315104e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Flexion contracture of finger |
| HP:0034681 | 9.21986850408e-06 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Finger joint contracture |
| HP:0020129 | 1.16989357552e-05 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal urine protein level |
| HP:0012575 | 1.22531246823e-05 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal nephron morphology |
| REAC:R-HSA-72306 | 1.32285423695e-05 | 0.571428571429 | TP53RK LAGE3 OSGEP TPRKB | tRNA processing |
| HP:0009473 | 1.94390140602e-05 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Joint contracture of the hand |
| HP:0002577 | 1.98503156388e-05 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal stomach morphology |
| HP:0000400 | 2.11260443232e-05 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Macrotia |
| GO:0002949 | 3.362820138e-05 | 0.428571428571 | TPRKB GON7 OSGEP | tRNA threonylcarbamoyladenosine modification |
| HP:0012385 | 3.51552256607e-05 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Camptodactyly |
| HP:0030044 | 3.85503015245e-05 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Flexion contracture of digit |
| HP:0100360 | 5.76952728839e-05 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Upper-limb joint contracture |
| HP:0002536 | 0.000116724462246 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal cortical gyration |
| HP:0000083 | 0.000132874270157 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Renal insufficiency |
| HP:0001172 | 0.000140600094898 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal thumb morphology |
| HP:0003121 | 0.00023044481394 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Limb joint contracture |
| GO:0006399 | 0.000260839333947 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | tRNA metabolic process |
| CORUM:7556 | 0.000307617328197 | 0.285714285714 | OSGEP LAGE3 | PRAME complex |
| HP:0002269 | 0.000324869105967 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of neuronal migration |
| HP:0001967 | 0.000339043524082 | 0.428571428571 | TP53RK GON7 OSGEP | Diffuse mesangial sclerosis |
| HP:0010549 | 0.000404828652384 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Weakness due to upper motor neuron dysfunction |
| HP:0002353 | 0.000494319449175 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | EEG abnormality |
| HP:0009810 | 0.000574253744683 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of upper limb joint |
| HP:0001966 | 0.000603109236937 | 0.428571428571 | TP53RK GON7 OSGEP | Abnormal glomerular mesangium morphology |
| HP:0030178 | 0.000670971168365 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of central nervous system electrophysiology |
| HP:0033354 | 0.000727604826676 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal urine metabolite level |
| HP:0100790 | 0.000780218965508 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Hernia |
| HP:0001511 | 0.00107050887907 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Intrauterine growth retardation |
| HP:0001311 | 0.00149177720866 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal nervous system electrophysiology |
| HP:0005918 | 0.00161183875642 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal finger phalanx morphology |
| HP:0012211 | 0.00176887047802 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal renal physiology |
| HP:0003110 | 0.00210229277984 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of urine homeostasis |
| HP:0011451 | 0.00321374930888 | 0.428571428571 | TP53RK LAGE3 TPRKB | Primary microcephaly |
| HP:0001371 | 0.00377461507065 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Flexion contracture |
| HP:0012444 | 0.00382897144051 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Brain atrophy |
| HP:0002538 | 0.00388394682689 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal cerebral cortex morphology |
| HP:0034392 | 0.00434666172411 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Joint contracture |
| HP:0000316 | 0.00437696949779 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Hypertelorism |
| HP:0000347 | 0.00488511708502 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Micrognathia |
| HP:0009118 | 0.00495178819045 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Aplasia/Hypoplasia of the mandible |
| HP:0100261 | 0.0050191786123 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal tendon morphology |
| HP:0009116 | 0.00526079219634 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Aplasia/Hypoplasia involving bones of the skull |
| HP:0007367 | 0.00628050156579 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Atrophy/Degeneration affecting the central nervous system |
| HP:0009122 | 0.00878766906609 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Aplasia/hypoplasia affecting bones of the axial skeleton |
| HP:0012718 | 0.00943956375974 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal gastrointestinal tract morphology |
| HP:0000164 | 0.00983714783527 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of the dentition |
| HP:0001197 | 0.00983714783527 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of prenatal development or birth |
| HP:0002118 | 0.0101883810368 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal cerebral ventricle morphology |
| HP:0100543 | 0.0116938672815 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Cognitive impairment |
| HP:0025033 | 0.0132236264343 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal digestive system morphology |
| HP:0011277 | 0.0158949053188 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of the urinary system physiology |
| HP:0100886 | 0.0181179803429 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of globe location |
| HP:0012210 | 0.0188789462622 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal renal morphology |
| HP:0000277 | 0.019367226078 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal mandible morphology |
| HP:0001276 | 0.0236432482893 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Hypertonia |
| HP:0030791 | 0.0248205324414 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal jaw morphology |
| HP:0001367 | 0.0251825922218 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal joint morphology |
| REAC:R-HSA-8953854 | 0.0288040045312 | 0.571428571429 | TP53RK LAGE3 OSGEP TPRKB | Metabolism of RNA |
| HP:0009115 | 0.0294473474739 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Aplasia/hypoplasia involving the skeleton |
| HP:0002493 | 0.0295849322776 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Upper motor neuron dysfunction |
| HP:0001167 | 0.0297230238661 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal finger morphology |
| HP:0000341 | 0.0317294880439 | 0.428571428571 | OSGEP GON7 LAGE3 | Narrow forehead |
| HP:0000377 | 0.0400275127441 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal pinna morphology |
| HP:0000356 | 0.0421707957735 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of the outer ear |
| HP:0034430 | 0.0444035262325 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormal joint physiology |
| HP:0011729 | 0.0444035262325 | 0.714285714286 | TP53RK LAGE3 GON7 OSGEP TPRKB | Abnormality of joint mobility |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| OSGEP | LAGE3 | 1.0 | 0.508 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM |
| TPRKB | LAGE3 | 1.0 | 0.326 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| TP53RK | LAGE3 | 1.0 | 0.382 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| TPRKB | OSGEP | 0.999 | 0.876 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| GON7 | OSGEP | 0.999 | 0.718 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| TP53RK | OSGEP | 0.999 | 0.902 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| TP53RK | TPRKB | 0.997 | 0.978 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| GON7 | TP53RK | 0.996 | 0.516 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GON7 | LAGE3 | 0.995 | 0.2 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| HYKK | LAGE3 | 0.995 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| HYKK | OSGEP | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PPIAL4C | LAGE3 | 0.975 | 0.108 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| GON7 | TPRKB | 0.973 | 0.328 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GON7 | HYKK | 0.946 | bioplex_WMM bioplex3_WMM WMM_only | |
| HYKK | PPIAL4C | 0.904 | bioplex3_WMM WMM_only | |
| TPRKB | HYKK | 0.888 | bioplex_WMM bioplex3_WMM WMM_only | |
| TP53RK | HYKK | 0.799 | bioplex_WMM bioplex3_WMM WMM_only | |
| GON7 | PPIAL4C | 0.703 | 0.0463076923077 | bioplex3_WMM WMM_only |
| TPRKB | PPIAL4C | 0.343 | 0.06 | bioplex3_WMM WMM_only |
| PPIAL4C | OSGEP | 0.302 | 0.062 | bioplex3_WMM WMM_only |
| TP53RK | PPIAL4C | 0.251 | 0.06 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GON7 | huMAP3_00664.1 huMAP3_11762.1 |
| TP53RK | huMAP3_00664.1 huMAP3_11762.1 |
| TPRKB | huMAP3_00664.1 huMAP3_11762.1 |
| HYKK | huMAP3_00664.1 huMAP3_03341.1 huMAP3_06279.1 huMAP3_07545.1 huMAP3_08405.1 huMAP3_11762.1 |
| PPIAL4C | huMAP3_00664.1 huMAP3_02030.1 huMAP3_04854.1 huMAP3_12332.1 huMAP3_15001.1 |
| OSGEP | huMAP3_00664.1 huMAP3_11762.1 |
| LAGE3 | huMAP3_00664.1 huMAP3_11762.1 |