hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00685.1
Complex Portal: CPX-15052
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | 5 | UniProt NCBI |
| KSR2 | Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6802948 | 0.000743311362176 | 1.0 | MAP2K1 KSR2 | Signaling by high-kinase activity BRAF mutants |
| REAC:R-HSA-5674135 | 0.000958615342944 | 1.0 | MAP2K1 KSR2 | MAP2K and MAPK activation |
| REAC:R-HSA-9656223 | 0.00101671324252 | 1.0 | MAP2K1 KSR2 | Signaling by RAF1 mutants |
| REAC:R-HSA-6802949 | 0.00120125951175 | 1.0 | MAP2K1 KSR2 | Signaling by RAS mutants |
| REAC:R-HSA-9649948 | 0.00120125951175 | 1.0 | MAP2K1 KSR2 | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802946 | 0.00120125951175 | 1.0 | MAP2K1 KSR2 | Signaling by moderate kinase activity BRAF mutants |
| REAC:R-HSA-6802955 | 0.00120125951175 | 1.0 | MAP2K1 KSR2 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802952 | 0.00263149309828 | 1.0 | MAP2K1 KSR2 | Signaling by BRAF and RAF1 fusions |
| KEGG:04014 | 0.00273702337615 | 1.0 | MAP2K1 KSR2 | Ras signaling pathway |
| REAC:R-HSA-6802957 | 0.00424627295404 | 1.0 | MAP2K1 KSR2 | Oncogenic MAPK signaling |
| WP:WP4223 | 0.00456751084292 | 1.0 | MAP2K1 KSR2 | Ras signaling |
| HPA:0100143 | 0.0351752340474 | 0.5 | KSR2 | cerebral cortex; neuronal projections[High] |
| REAC:R-HSA-5673001 | 0.0385804228396 | 1.0 | MAP2K1 KSR2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0400465404229 | 1.0 | MAP2K1 KSR2 | MAPK1/MAPK3 signaling |
| WP:WP4269 | 0.049750157242 | 0.5 | MAP2K1 | Ethanol metabolism production of ROS by CYP2E1 |
| CORUM:5872 | 0.0499419797295 | 0.5 | MAP2K1 | BRAF-MAP2K1-MAP2K2-YWHAE complex |
| CORUM:5921 | 0.0499419797295 | 0.5 | MAP2K1 | KSR1-BRAF-MEK complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAP2K1 | KSR2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| MAP2K1 | huMAP3_00685.1 huMAP3_14744.1 |
| KSR2 | huMAP3_00685.1 huMAP3_14744.1 |