hu.MAP 3.0: Complex View

Genename	Protein Name	Uniprot Annotation Score	Links
MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)	5	UniProt NCBI
KSR2	Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)	5	UniProt NCBI

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-6802948	0.000743311362176	1.0	KSR2 MAP2K1	Signaling by high-kinase activity BRAF mutants
REAC:R-HSA-5674135	0.000958615342944	1.0	KSR2 MAP2K1	MAP2K and MAPK activation
REAC:R-HSA-9656223	0.00101671324252	1.0	KSR2 MAP2K1	Signaling by RAF1 mutants
REAC:R-HSA-6802949	0.00120125951175	1.0	KSR2 MAP2K1	Signaling by RAS mutants
REAC:R-HSA-9649948	0.00120125951175	1.0	KSR2 MAP2K1	Signaling downstream of RAS mutants
REAC:R-HSA-6802946	0.00120125951175	1.0	KSR2 MAP2K1	Signaling by moderate kinase activity BRAF mutants
REAC:R-HSA-6802955	0.00120125951175	1.0	KSR2 MAP2K1	Paradoxical activation of RAF signaling by kinase inactive BRAF
REAC:R-HSA-6802952	0.00263149309828	1.0	KSR2 MAP2K1	Signaling by BRAF and RAF1 fusions
KEGG:04014	0.00273702337615	1.0	KSR2 MAP2K1	Ras signaling pathway
REAC:R-HSA-6802957	0.00424627295404	1.0	KSR2 MAP2K1	Oncogenic MAPK signaling
WP:WP4223	0.00456751084292	1.0	KSR2 MAP2K1	Ras signaling
HPA:0100143	0.0351752340474	0.5	KSR2	cerebral cortex; neuronal projections[High]
REAC:R-HSA-5673001	0.0385804228396	1.0	KSR2 MAP2K1	RAF/MAP kinase cascade
REAC:R-HSA-5684996	0.0400465404229	1.0	KSR2 MAP2K1	MAPK1/MAPK3 signaling
WP:WP4269	0.049750157242	0.5	MAP2K1	Ethanol metabolism production of ROS by CYP2E1
CORUM:5872	0.0499419797295	0.5	MAP2K1	BRAF-MAP2K1-MAP2K2-YWHAE complex
CORUM:5921	0.0499419797295	0.5	MAP2K1	KSR1-BRAF-MEK complex

Protein 1	Protein 2	Score	ProteomeHD	Evidence
MAP2K1	KSR2	0.999		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only

Genename	Complexes
MAP2K1	huMAP3_00685.1 huMAP3_14744.1
KSR2	huMAP3_00685.1 huMAP3_14744.1