hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00687.1
Complex Portal: CPX-19566
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GCK | Hexokinase-4 (HK4) (EC 2.7.1.1) (Glucokinase) (Hexokinase type IV) (HK IV) (Hexokinase-D) | 5 | UniProt NCBI |
| HK3 | Hexokinase-3 (EC 2.7.1.1) (Hexokinase type III) (HK III) (Hexokinase-C) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00524 | 1.62569694473e-06 | 1.0 | GCK HK3 | Neomycin, kanamycin and gentamicin biosynthesis |
| WP:WP5394 | 1.91536658216e-05 | 1.0 | GCK HK3 | UDP derived sugars synthesis in fibroblasts |
| KEGG:00500 | 4.8770908342e-05 | 1.0 | GCK HK3 | Starch and sucrose metabolism |
| KEGG:00052 | 5.28351507038e-05 | 1.0 | GCK HK3 | Galactose metabolism |
| KEGG:01250 | 9.67289682117e-05 | 1.0 | GCK HK3 | Biosynthesis of nucleotide sugars |
| KEGG:04930 | 0.000133307149468 | 1.0 | GCK HK3 | Type II diabetes mellitus |
| KEGG:00520 | 0.000160943997529 | 1.0 | GCK HK3 | Amino sugar and nucleotide sugar metabolism |
| KEGG:00010 | 0.000307419292249 | 1.0 | GCK HK3 | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.000359441594481 | 1.0 | GCK HK3 | Central carbon metabolism in cancer |
| WP:WP534 | 0.00036647347272 | 1.0 | GCK HK3 | Glycolysis and gluconeogenesis |
| KEGG:01200 | 0.000870723283599 | 1.0 | GCK HK3 | Carbon metabolism |
| KEGG:04910 | 0.00128023634398 | 1.0 | GCK HK3 | Insulin signaling pathway |
| WP:WP5355 | 0.00155570330173 | 1.0 | GCK HK3 | Metabolic Epileptic Disorders |
| REAC:R-HSA-70171 | 0.00355422444443 | 1.0 | GCK HK3 | Glycolysis |
| GO:0008865 | 0.00468200720083 | 1.0 | GCK HK3 | fructokinase activity |
| GO:0004396 | 0.00468200720083 | 1.0 | GCK HK3 | hexokinase activity |
| GO:0004340 | 0.00468200720083 | 1.0 | GCK HK3 | glucokinase activity |
| REAC:R-HSA-70326 | 0.00526469495831 | 1.0 | GCK HK3 | Glucose metabolism |
| GO:0046835 | 0.0210690324038 | 1.0 | GCK HK3 | carbohydrate phosphorylation |
| REAC:R-HSA-5619073 | 0.0249718442457 | 0.5 | GCK | Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) |
| KEGG:04950 | 0.0356198329076 | 0.5 | GCK | Maturity onset diabetes of the young |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GCK | HK3 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes