hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00688.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SHCBP1 | SHC SH2 domain-binding protein 1 | 3 | UniProt NCBI |
| CD2AP | CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains) | 5 | UniProt NCBI |
| KIF23 | Kinesin-like protein KIF23 (Kinesin-like protein 5) (Mitotic kinesin-like protein 1) | 5 | UniProt NCBI |
| RACGAP1 | Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:929 | 4.19173080197e-06 | 0.75 | RACGAP1 SHCBP1 KIF23 | CEN complex |
| CORUM:7440 | 5.12628525639e-06 | 0.5 | RACGAP1 KIF23 | KIF23-RACGAP1 complex |
| CORUM:7439 | 1.53774525569e-05 | 0.5 | RACGAP1 KIF23 | ECT2-KIF23-RACGAP1 complex |
| HP:0025035 | 3.34429085774e-05 | 0.5 | RACGAP1 KIF23 | Abnormal proerythroblast morphology |
| HP:0033212 | 0.000100319571443 | 0.5 | RACGAP1 KIF23 | Abnormal total iron binding capacity |
| HP:0025196 | 0.000100319571443 | 0.5 | RACGAP1 KIF23 | Increased total iron binding capacity |
| WP:WP5199 | 0.000168398502686 | 0.5 | RACGAP1 KIF23 | PtdIns 4 5 P2 in cytokinesis pathway |
| HP:0020047 | 0.000701980712879 | 0.5 | RACGAP1 KIF23 | Abnormal myeloid cell morphology |
| HP:0012130 | 0.000701980712879 | 0.5 | RACGAP1 KIF23 | Abnormal erythroid lineage cell morphology |
| HP:0003452 | 0.00120317586686 | 0.5 | RACGAP1 KIF23 | Increased serum iron |
| HP:0011891 | 0.00150383256857 | 0.5 | RACGAP1 KIF23 | Post-partum hemorrhage |
| HP:0040130 | 0.00400802433742 | 0.5 | RACGAP1 KIF23 | Abnormal serum iron concentration |
| HP:0011273 | 0.00454201288615 | 0.5 | RACGAP1 KIF23 | Anisocytosis |
| HP:0002249 | 0.0051092979876 | 0.5 | RACGAP1 KIF23 | Melena |
| HP:0030140 | 0.0057098705025 | 0.5 | RACGAP1 KIF23 | Oral cavity bleeding |
| HP:0011031 | 0.00701084122037 | 0.5 | RACGAP1 KIF23 | Abnormality of iron homeostasis |
| GO:0097149 | 0.00842684400117 | 0.5 | RACGAP1 KIF23 | centralspindlin complex |
| HP:0011890 | 0.00844485194452 | 0.5 | RACGAP1 KIF23 | Prolonged bleeding following procedure |
| REAC:R-HSA-983189 | 0.0146019089592 | 0.5 | RACGAP1 KIF23 | Kinesins |
| HP:0002315 | 0.0170407149806 | 0.75 | CD2AP KIF23 RACGAP1 | Headache |
| HP:0025085 | 0.0234332085093 | 0.5 | RACGAP1 KIF23 | Bloody diarrhea |
| HP:0011030 | 0.0234332085093 | 0.5 | RACGAP1 KIF23 | Abnormal blood transition element cation concentration |
| HP:0000225 | 0.034474601612 | 0.5 | RACGAP1 KIF23 | Gingival bleeding |
| HP:0004447 | 0.036003514982 | 0.5 | RACGAP1 KIF23 | Poikilocytosis |
| HP:0005518 | 0.0375654511359 | 0.5 | RACGAP1 KIF23 | Increased mean corpuscular volume |
| REAC:R-HSA-6811434 | 0.0434971593242 | 0.5 | RACGAP1 KIF23 | COPI-dependent Golgi-to-ER retrograde traffic |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KIF23 | RACGAP1 | 1.0 | 0.794 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| SHCBP1 | RACGAP1 | 0.999 | 0.146 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () boldt_WMM |
| SHCBP1 | KIF23 | 0.99 | 0.128 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM boldt_WMM |
| SHCBP1 | CD2AP | 0.982 | 0.068 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| CD2AP | KIF23 | 0.978 | 0.249714285714 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
| CD2AP | RACGAP1 | 0.976 | 0.168 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM |
Related Complexes