hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00689.1
Complex Portal: CPX-11916
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PGLYRP1 | Peptidoglycan recognition protein 1 (Peptidoglycan recognition protein short) (PGRP-S) | 5 | UniProt NCBI |
| OR6C70 | Olfactory receptor 6C70 | 3 | UniProt NCBI |
| SCGB1A1 | Uteroglobin (Club cell phospholipid-binding protein) (CCPBP) (Club cells 10 kDa secretory protein) (CC10) (Secretoglobin family 1A member 1) (Urinary protein 1) (UP-1) (UP1) (Urine protein 1) | 5 | UniProt NCBI |
| PADI2 | Protein-arginine deiminase type-2 (EC 3.5.3.15) (PAD-H19) (Peptidylarginine deiminase II) (Protein-arginine deiminase type II) | 5 | UniProt NCBI |
| APOL1 | Apolipoprotein L1 (Apolipoprotein L) (Apo-L) (ApoL) (Apolipoprotein L-I) (ApoL-I) | 5 | UniProt NCBI |
| DYSF | Dysferlin (Dystrophy-associated fer-1-like protein) (Fer-1-like protein 1) | 5 | UniProt NCBI |
| CAMP | Cathelicidin antimicrobial peptide (18 kDa cationic antimicrobial protein) (CAP-18) (hCAP-18) [Cleaved into: Antibacterial peptide FALL-39 (FALL-39 peptide antibiotic); Antibacterial peptide LL-37; Antibacterial peptide KR-20; Antibacterial peptide LL-23; Antibacterial peptide LL-29; Antibacterial peptide KS-30; Antibacterial peptide RK-31; Antibacterial peptide FF-33] | 5 | UniProt NCBI |
| CFI | Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain] | 5 | UniProt NCBI |
| PTPRC | Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45) | 5 | UniProt NCBI |
| NCF2 | Neutrophil cytosol factor 2 (NCF-2) (67 kDa neutrophil oxidase factor) (NADPH oxidase activator 2) (Neutrophil NADPH oxidase factor 2) (p67-phox) | 5 | UniProt NCBI |
| APOC1 | Apolipoprotein C-I (Apo-CI) (ApoC-I) (Apolipoprotein C1) [Cleaved into: Truncated apolipoprotein C-I] | 5 | UniProt NCBI |
| KLK10 | Kallikrein-10 (EC 3.4.21.-) (Normal epithelial cell-specific 1) (Protease serine-like 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-168249 | 0.00454683274465 | 0.545454545455 | PTPRC NCF2 PADI2 CAMP CFI PGLYRP1 | Innate Immune System |
| HPA:0640411 | 0.0183496241297 | 0.181818181818 | DYSF NCF2 | endometrium; macrophages[>=Low] |
| HPA:0640412 | 0.0183496241297 | 0.181818181818 | DYSF NCF2 | endometrium; macrophages[>=Medium] |
| HPA:0640203 | 0.020009552639 | 0.181818181818 | DYSF NCF2 | endometrium; endothelial cells[High] |
| WP:WP5115 | 0.0252993422133 | 0.272727272727 | APOL1 APOC1 CFI | Network map of SARS CoV 2 signaling pathway |
| KEGG:05150 | 0.032801718022 | 0.181818181818 | CAMP CFI | Staphylococcus aureus infection |
| HPA:0640202 | 0.0429421086875 | 0.181818181818 | DYSF NCF2 | endometrium; endothelial cells[>=Medium] |
| HPA:0640201 | 0.0480268300719 | 0.181818181818 | DYSF NCF2 | endometrium; endothelial cells[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| CFI | KLK10 | 0.992 | ||
| APOL1 | KLK10 | 0.989 | ||
| APOC1 | KLK10 | 0.989 | ||
| DYSF | KLK10 | 0.984 | ||
| PADI2 | KLK10 | 0.977 | ||
| PTPRC | KLK10 | 0.975 | ||
| CAMP | KLK10 | 0.97 | ||
| PGLYRP1 | KLK10 | 0.97 | ||
| OR6C70 | KLK10 | 0.968 | ||
| SCGB1A1 | KLK10 | 0.964 | ||
| NCF2 | KLK10 | 0.962 | ||
| PGLYRP1 | PTPRC | 0.902 | ||
| DYSF | PTPRC | 0.902 | 0.325010752688 | |
| PTPRC | NCF2 | 0.902 | 0.1606 | |
| PGLYRP1 | APOC1 | 0.902 | ||
| CAMP | APOC1 | 0.902 | ||
| APOL1 | DYSF | 0.902 | 0.110115942029 | |
| APOL1 | CAMP | 0.902 | ||
| SCGB1A1 | PTPRC | 0.902 | ||
| PGLYRP1 | NCF2 | 0.902 | ||
| DYSF | APOC1 | 0.902 | ||
| APOL1 | APOC1 | 0.902 | ||
| APOL1 | PTPRC | 0.902 | 0.302 | |
| CAMP | NCF2 | 0.902 | ||
| SCGB1A1 | NCF2 | 0.902 | ||
| SCGB1A1 | APOC1 | 0.902 | ||
| SCGB1A1 | CAMP | 0.902 | ||
| NCF2 | APOC1 | 0.902 | ||
| PGLYRP1 | DYSF | 0.902 | ||
| SCGB1A1 | APOL1 | 0.902 | ||
| CAMP | PTPRC | 0.902 | 0.318 | |
| APOL1 | NCF2 | 0.902 | ||
| PGLYRP1 | CAMP | 0.902 |
mutually_exclusive (P02750)
structurally_consistent (dimer) |
|
| DYSF | NCF2 | 0.902 | 0.07 | |
| PGLYRP1 | APOL1 | 0.902 | ||
| SCGB1A1 | DYSF | 0.902 | ||
| DYSF | CAMP | 0.902 | 0.066 | |
| PGLYRP1 | SCGB1A1 | 0.902 | ||
| PTPRC | APOC1 | 0.902 | ||
| PGLYRP1 | CFI | 0.902 | ||
| APOL1 | CFI | 0.902 | 0.222 | |
| PADI2 | APOL1 | 0.902 | ||
| PADI2 | DYSF | 0.902 | 0.096 | |
| CFI | APOC1 | 0.902 | ||
| PADI2 | CFI | 0.902 | ||
| CAMP | CFI | 0.902 | ||
| PADI2 | APOC1 | 0.902 | ||
| PGLYRP1 | PADI2 | 0.902 | ||
| PADI2 | NCF2 | 0.902 | 0.132 | |
| PADI2 | PTPRC | 0.902 | 0.28 | |
| CFI | NCF2 | 0.902 | ||
| SCGB1A1 | PADI2 | 0.902 | ||
| DYSF | CFI | 0.902 | 0.112 | |
| CFI | PTPRC | 0.902 | 0.318 | |
| PADI2 | CAMP | 0.902 | 0.118 | |
| SCGB1A1 | CFI | 0.902 | ||
| OR6C70 | APOC1 | 0.214 | ||
| OR6C70 | DYSF | 0.214 | ||
| OR6C70 | CAMP | 0.214 | ||
| OR6C70 | APOL1 | 0.214 | ||
| OR6C70 | CFI | 0.214 | ||
| OR6C70 | PTPRC | 0.214 | ||
| OR6C70 | PADI2 | 0.214 | ||
| PGLYRP1 | OR6C70 | 0.214 | ||
| OR6C70 | NCF2 | 0.214 | ||
| OR6C70 | SCGB1A1 | 0.214 |
Related Complexes