hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00694.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG16L2 | Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) | 4 | UniProt NCBI |
| RAB33B | Ras-related protein Rab-33B | 5 | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | 5 | UniProt NCBI |
| ATG12 | Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) | 5 | UniProt NCBI |
| TECPR1 | Tectonin beta-propeller repeat-containing protein 1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4863 | 9.83834482812e-07 | 0.6 | ATG16L2 ATG5 ATG12 | Host pathogen interaction of human coronaviruses autophagy |
| KEGG:04140 | 3.00693972585e-06 | 0.8 | ATG16L2 ATG12 RAB33B ATG5 | Autophagy - animal |
| GO:0034274 | 1.92180881975e-05 | 0.6 | ATG16L2 ATG5 ATG12 | Atg12-Atg5-Atg16 complex |
| GO:0005776 | 0.000168126820122 | 0.8 | TECPR1 ATG16L2 ATG5 ATG12 | autophagosome |
| REAC:R-HSA-8934903 | 0.000425287580531 | 0.4 | ATG5 ATG12 | Receptor Mediated Mitophagy |
| GO:0034045 | 0.000436807598019 | 0.6 | ATG16L2 ATG5 ATG12 | phagophore assembly site membrane |
| GO:1901096 | 0.000537554131189 | 0.6 | TECPR1 ATG5 ATG12 | regulation of autophagosome maturation |
| WP:WP2509 | 0.00135500760343 | 0.4 | ATG5 ATG12 | Nanoparticle triggered autophagic cell death |
| KEGG:05131 | 0.00175429069912 | 0.6 | TECPR1 ATG5 ATG12 | Shigellosis |
| KEGG:04136 | 0.00196978543336 | 0.4 | ATG5 ATG12 | Autophagy - other |
| WP:WP4923 | 0.00221546358612 | 0.4 | ATG5 ATG12 | Autophagy |
| REAC:R-HSA-5205685 | 0.00318398402781 | 0.4 | ATG5 ATG12 | PINK1-PRKN Mediated Mitophagy |
| WP:WP4577 | 0.00456408083355 | 0.4 | ATG5 ATG12 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| GO:0000407 | 0.00475337188383 | 0.6 | ATG16L2 ATG5 ATG12 | phagophore assembly site |
| REAC:R-HSA-5205647 | 0.00492422076745 | 0.4 | ATG5 ATG12 | Mitophagy |
| REAC:R-HSA-936440 | 0.00799229651072 | 0.4 | ATG5 ATG12 | Negative regulators of DDX58/IFIH1 signaling |
| WP:WP3865 | 0.00835727861991 | 0.4 | ATG5 ATG12 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04622 | 0.00937366158534 | 0.4 | ATG5 ATG12 | RIG-I-like receptor signaling pathway |
| WP:WP4655 | 0.0121292354685 | 0.4 | ATG5 ATG12 | Cytosolic DNA sensing pathway |
| WP:WP5205 | 0.0132783799217 | 0.4 | ATG5 ATG12 | Clock controlled autophagy in bone metabolism |
| GO:1904973 | 0.0140440992017 | 0.4 | ATG5 ATG12 | positive regulation of viral translation |
| GO:1904971 | 0.0140440992017 | 0.4 | ATG5 ATG12 | regulation of viral translation |
| GO:0097352 | 0.0176256341648 | 0.6 | TECPR1 ATG5 ATG12 | autophagosome maturation |
| GO:0016236 | 0.029345634756 | 0.8 | TECPR1 ATG16L2 ATG5 ATG12 | macroautophagy |
| REAC:R-HSA-168928 | 0.0417637628913 | 0.4 | ATG5 ATG12 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| REAC:R-HSA-9663891 | 0.0417637628913 | 0.4 | ATG5 ATG12 | Selective autophagy |
| KEGG:04621 | 0.0471742362289 | 0.4 | ATG5 ATG12 | NOD-like receptor signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATG5 | TECPR1 | 0.999 | 0.09 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | ATG12 | 0.999 | 0.442 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| RAB33B | ATG5 | 0.999 | 0.14 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG16L2 | ATG5 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB33B | ATG12 | 0.998 | 0.118 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG16L2 | TECPR1 | 0.946 | bioplex3_WMM WMM_only | |
| ATG16L2 | ATG12 | 0.779 | bioplex3_WMM WMM_only | |
| ATG12 | TECPR1 | 0.779 | 0.134 | bioplex3_WMM WMM_only |
Related Complexes