hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00707.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SEC24C | Protein transport protein Sec24C (SEC24-related protein C) | 5 | UniProt NCBI |
| SEC23B | Protein transport protein Sec23B (hSec23B) (SEC23-related protein B) | 5 | UniProt NCBI |
| SEC23A | Protein transport protein Sec23A (hSec23A) (SEC23-related protein A) | 5 | UniProt NCBI |
| SEC24D | Protein transport protein Sec24D (SEC24-related protein D) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP1982 | 1.94805563676e-08 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Sterol regulatory element binding proteins SREBP signaling |
| GO:0030127 | 4.78889884367e-08 | 1.0 | SEC23A SEC24D SEC24C SEC23B | COPII vesicle coat |
| GO:0090110 | 4.78889884367e-08 | 1.0 | SEC23A SEC24D SEC24C SEC23B | COPII-coated vesicle cargo loading |
| GO:0070971 | 3.93373833587e-07 | 1.0 | SEC23A SEC24D SEC24C SEC23B | endoplasmic reticulum exit site |
| KEGG:04141 | 5.57703614666e-07 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Protein processing in endoplasmic reticulum |
| GO:0035459 | 8.27926934703e-07 | 1.0 | SEC23A SEC24D SEC24C SEC23B | vesicle cargo loading |
| GO:0090114 | 2.16424021313e-06 | 1.0 | SEC23A SEC24D SEC24C SEC23B | COPII-coated vesicle budding |
| REAC:R-HSA-5694530 | 4.0993398561e-06 | 0.75 | SEC23A SEC24C SEC24D | Cargo concentration in the ER |
| REAC:R-HSA-983170 | 4.0993398561e-06 | 0.75 | SEC23A SEC24C SEC24D | Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| GO:0012507 | 5.11991174176e-06 | 1.0 | SEC23A SEC24D SEC24C SEC23B | ER to Golgi transport vesicle membrane |
| GO:0030120 | 1.03937523749e-05 | 1.0 | SEC23A SEC24D SEC24C SEC23B | vesicle coat |
| GO:0006900 | 2.70701716559e-05 | 1.0 | SEC23A SEC24D SEC24C SEC23B | vesicle budding from membrane |
| REAC:R-HSA-1655829 | 2.7436612495e-05 | 0.75 | SEC23A SEC24C SEC24D | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| GO:0030134 | 2.86394569693e-05 | 1.0 | SEC23A SEC24D SEC24C SEC23B | COPII-coated ER to Golgi transport vesicle |
| REAC:R-HSA-204005 | 5.03512663474e-05 | 0.75 | SEC23A SEC24C SEC24D | COPII-mediated vesicle transport |
| GO:0048475 | 5.85691538001e-05 | 1.0 | SEC23A SEC24D SEC24C SEC23B | coated membrane |
| GO:0030117 | 5.85691538001e-05 | 1.0 | SEC23A SEC24D SEC24C SEC23B | membrane coat |
| GO:0030658 | 0.000181908164461 | 1.0 | SEC23A SEC24D SEC24C SEC23B | transport vesicle membrane |
| GO:0006888 | 0.00020191878878 | 1.0 | SEC23A SEC24D SEC24C SEC23B | endoplasmic reticulum to Golgi vesicle-mediated transport |
| REAC:R-HSA-9705671 | 0.00031803083943 | 0.75 | SEC23A SEC24C SEC24D | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-2132295 | 0.000362881762367 | 0.75 | SEC23A SEC24C SEC24D | MHC class II antigen presentation |
| REAC:R-HSA-8957322 | 0.00041175394675 | 0.75 | SEC23A SEC24C SEC24D | Metabolism of steroids |
| GO:0030662 | 0.000491307867445 | 1.0 | SEC23A SEC24D SEC24C SEC23B | coated vesicle membrane |
| REAC:R-HSA-199977 | 0.000664788606793 | 0.75 | SEC23A SEC24C SEC24D | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 0.00115920951182 | 0.75 | SEC23A SEC24C SEC24D | Transport to the Golgi and subsequent modification |
| HP:0002868 | 0.00120317586686 | 0.5 | SEC23A SEC24D | Narrow iliac wing |
| REAC:R-HSA-9705683 | 0.00151474987795 | 0.75 | SEC23A SEC24C SEC24D | SARS-CoV-2-host interactions |
| GO:0030135 | 0.00263891757684 | 1.0 | SEC23A SEC24D SEC24C SEC23B | coated vesicle |
| GO:0030133 | 0.00431684695428 | 1.0 | SEC23A SEC24D SEC24C SEC23B | transport vesicle |
| REAC:R-HSA-9694516 | 0.00464100691605 | 0.75 | SEC23A SEC24C SEC24D | SARS-CoV-2 Infection |
| HP:0000765 | 0.00469631940203 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Abnormal thorax morphology |
| REAC:R-HSA-446203 | 0.00516924519396 | 0.75 | SEC23A SEC24C SEC24D | Asparagine N-linked glycosylation |
| GO:0048193 | 0.00569790407237 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Golgi vesicle transport |
| GO:0016050 | 0.00669062030536 | 1.0 | SEC23A SEC24D SEC24C SEC23B | vesicle organization |
| REAC:R-HSA-983169 | 0.00943434452943 | 0.75 | SEC23A SEC24C SEC24D | Class I MHC mediated antigen processing & presentation |
| HP:0002650 | 0.0102119274289 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Scoliosis |
| REAC:R-HSA-9679506 | 0.0120967178818 | 0.75 | SEC23A SEC24C SEC24D | SARS-CoV Infections |
| HP:0000174 | 0.0121619400741 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Abnormal palate morphology |
| HP:0010674 | 0.0139897634326 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Abnormal curvature of the vertebral column |
| HP:0011061 | 0.0208931776605 | 0.75 | SEC23A SEC24C SEC24D | Abnormality of dental structure |
| HP:0011329 | 0.0257530649301 | 0.75 | SEC23A SEC24C SEC24D | Abnormality of cranial sutures |
| HP:0004322 | 0.0263940803883 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Short stature |
| HP:0000262 | 0.0273256954732 | 0.5 | SEC24C SEC24D | Turricephaly |
| KEGG:05130 | 0.0334335704012 | 0.5 | SEC24C SEC24D | Pathogenic Escherichia coli infection |
| HP:0000002 | 0.0361997133303 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Abnormality of body height |
| HP:0000256 | 0.0379108682761 | 0.75 | SEC23A SEC23B SEC24D | Macrocephaly |
| HP:0011867 | 0.0391604009626 | 0.5 | SEC23A SEC24D | Abnormal iliac wing morphology |
| HP:0000925 | 0.0393256235707 | 1.0 | SEC23A SEC24D SEC24C SEC23B | Abnormality of the vertebral column |
| HP:0040194 | 0.0407260045359 | 0.75 | SEC23A SEC23B SEC24D | Increased head circumference |
| REAC:R-HSA-199991 | 0.0424877030349 | 0.75 | SEC23A SEC24C SEC24D | Membrane Trafficking |
| HP:0000235 | 0.0453746914491 | 0.75 | SEC23A SEC24C SEC24D | Abnormality of the fontanelles or cranial sutures |
| CORUM:7139 | 0.049938562206 | 0.25 | SEC23A | SEC23-SEC24 adaptor complex |
| REAC:R-HSA-5653656 | 0.0499402458571 | 0.75 | SEC23A SEC24C SEC24D | Vesicle-mediated transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SEC23B | SEC24C | 1.0 | 0.268 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23A | SEC24C | 1.0 | 0.53 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction treiber_WMM |
| SEC23B | SEC23A | 1.0 | 0.106 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction |
| SEC23B | SEC24D | 0.993 | 0.208 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SEC23A | SEC24D | 0.981 | 0.302631578947 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo fraction |
| SEC24D | SEC24C | 0.602 | 0.136 | bioplex_WMM bioplex3_WMM Malo fraction |
Related Complexes