hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00708.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIP4K2A | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha) | 5 | UniProt NCBI |
| PIP4K2B | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8847453 | 1.02525705128e-05 | 1.0 | PIP4K2A PIP4K2B | Synthesis of PIPs in the nucleus |
| REAC:R-HSA-6811555 | 6.15154230766e-05 | 1.0 | PIP4K2A PIP4K2B | PI5P Regulates TP53 Acetylation |
| KEGG:00562 | 0.000338144964505 | 1.0 | PIP4K2A PIP4K2B | Inositol phosphate metabolism |
| WP:WP4971 | 0.00036647347272 | 1.0 | PIP4K2A PIP4K2B | Phosphoinositides metabolism |
| WP:WP5411 | 0.00036647347272 | 1.0 | PIP4K2A PIP4K2B | Phosphatidyl inositol phosphate pathway |
| KEGG:04070 | 0.00058037380927 | 1.0 | PIP4K2A PIP4K2B | Phosphatidylinositol signaling system |
| REAC:R-HSA-6804758 | 0.000743311362176 | 1.0 | PIP4K2A PIP4K2B | Regulation of TP53 Activity through Acetylation |
| GO:1902633 | 0.00140460216025 | 1.0 | PIP4K2A PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process |
| GO:0016309 | 0.00140460216025 | 1.0 | PIP4K2A PIP4K2B | 1-phosphatidylinositol-5-phosphate 4-kinase activity |
| GO:1902635 | 0.00140460216025 | 1.0 | PIP4K2A PIP4K2B | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process |
| REAC:R-HSA-1660499 | 0.00184717145405 | 1.0 | PIP4K2A PIP4K2B | Synthesis of PIPs at the plasma membrane |
| KEGG:04810 | 0.00307500577096 | 1.0 | PIP4K2A PIP4K2B | Regulation of actin cytoskeleton |
| WP:WP51 | 0.0034595776844 | 1.0 | PIP4K2A PIP4K2B | Regulation of actin cytoskeleton |
| REAC:R-HSA-1483255 | 0.00436759503844 | 1.0 | PIP4K2A PIP4K2B | PI Metabolism |
| REAC:R-HSA-6811558 | 0.0046153654925 | 1.0 | PIP4K2A PIP4K2B | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| REAC:R-HSA-199418 | 0.0055363880769 | 1.0 | PIP4K2A PIP4K2B | Negative regulation of the PI3K/AKT network |
| GO:0061909 | 0.0131096201623 | 1.0 | PIP4K2A PIP4K2B | autophagosome-lysosome fusion |
| GO:0016308 | 0.0131096201623 | 1.0 | PIP4K2A PIP4K2B | 1-phosphatidylinositol-4-phosphate 5-kinase activity |
| REAC:R-HSA-5633007 | 0.0196097498674 | 1.0 | PIP4K2A PIP4K2B | Regulation of TP53 Activity |
| REAC:R-HSA-1483257 | 0.0263149309828 | 1.0 | PIP4K2A PIP4K2B | Phospholipid metabolism |
| REAC:R-HSA-1257604 | 0.0450002407423 | 1.0 | PIP4K2A PIP4K2B | PIP3 activates AKT signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PIP4K2A | PIP4K2B | 1.0 | 0.318 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
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