hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00715.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG101 | Autophagy-related protein 101 | 5 | UniProt NCBI |
| ULK2 | Serine/threonine-protein kinase ULK2 (EC 2.7.11.1) (Unc-51-like kinase 2) | 5 | UniProt NCBI |
| ULK1 | Serine/threonine-protein kinase ULK1 (EC 2.7.11.1) (Autophagy-related protein 1 homolog) (ATG1) (hATG1) (Unc-51-like kinase 1) | 5 | UniProt NCBI |
| RB1CC1 | RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200) | 5 | UniProt NCBI |
| ATG13 | Autophagy-related protein 13 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6232 | 3.83566049696e-13 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | ULK1-ATG13-RB1CC1-ATG101 complex |
| CORUM:7091 | 3.83566049696e-13 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | FIP200-ULK1-ATG13-ATG101 complex |
| CORUM:7065 | 1.34226065824e-11 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | WDR41-(C9orf72-SMCR8)-(FIP200-ULK1-ATG13-ATG101) complex |
| WP:WP5412 | 1.65355038993e-10 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | 8q11 23 RB1CC1 copy number variation |
| WP:WP4863 | 5.05370170799e-10 | 0.8 | RB1CC1 ATG13 ULK2 ULK1 | Host pathogen interaction of human coronaviruses autophagy |
| GO:0000407 | 1.81326821645e-09 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | phagophore assembly site |
| KEGG:05017 | 2.05030220587e-09 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | Spinocerebellar ataxia |
| CORUM:6229 | 2.80233355908e-09 | 0.6 | RB1CC1 ULK1 ATG13 | ULK1-ATG13-RB1CC1 complex |
| CORUM:6230 | 2.80233355908e-09 | 0.6 | RB1CC1 ULK2 ATG13 | ULK2-ATG13-RB1CC1 complex |
| WP:WP4923 | 3.37966808219e-09 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | Autophagy |
| KEGG:04140 | 6.3088166291e-09 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | Autophagy - animal |
| WP:WP4577 | 1.50751971039e-08 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| GO:1990316 | 1.65724193228e-08 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | Atg1/ULK1 kinase complex |
| GO:1903059 | 2.76191861336e-08 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | regulation of protein lipidation |
| GO:0034727 | 2.76191861336e-08 | 0.8 | RB1CC1 ATG13 ULK2 ULK1 | piecemeal microautophagy of the nucleus |
| WP:WP2059 | 5.93602918815e-08 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | Alzheimer 39 s disease and miRNA effects |
| WP:WP5124 | 5.93602918815e-08 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | Alzheimer 39 s disease |
| GO:0050746 | 9.40213012535e-08 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | regulation of lipoprotein metabolic process |
| KEGG:05016 | 1.02604700914e-07 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | Huntington disease |
| WP:WP5205 | 1.34130161218e-07 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | Clock controlled autophagy in bone metabolism |
| GO:0016237 | 1.79475545894e-07 | 0.8 | RB1CC1 ATG13 ULK2 ULK1 | microautophagy |
| GO:0034045 | 1.79475545894e-07 | 0.8 | RB1CC1 ATG13 ULK2 ULK1 | phagophore assembly site membrane |
| KEGG:04211 | 2.11615588461e-07 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | Longevity regulating pathway |
| KEGG:05014 | 2.52170502175e-07 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | Amyotrophic lateral sclerosis |
| GO:0044804 | 3.12897432326e-07 | 0.8 | RB1CC1 ATG13 ULK2 ULK1 | nucleophagy |
| KEGG:05010 | 3.21366321828e-07 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | Alzheimer disease |
| GO:0000045 | 5.50384964004e-07 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | autophagosome assembly |
| GO:1905037 | 6.77918257941e-07 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | autophagosome organization |
| KEGG:05022 | 8.64787006633e-07 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | Pathways of neurodegeneration - multiple diseases |
| GO:0010508 | 2.11181127205e-06 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | positive regulation of autophagy |
| WP:WP5381 | 2.51481712646e-06 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | Smith Magenis and Potocki Lupski syndrome copy number variation |
| KEGG:04136 | 3.77831543883e-06 | 0.6 | ATG101 ULK2 ATG13 | Autophagy - other |
| REAC:R-HSA-1632852 | 4.24686934885e-06 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | Macroautophagy |
| WP:WP3844 | 4.88902625878e-06 | 0.6 | RB1CC1 ULK1 ATG13 | PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer |
| REAC:R-HSA-9612973 | 6.68872511108e-06 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | Autophagy |
| GO:0007033 | 1.37870221294e-05 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | vacuole organization |
| WP:WP5420 | 3.07885103634e-05 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | ADHD and autism ASD linked metabolic pathways and SNP |
| CORUM:6816 | 8.18785830799e-05 | 0.4 | ULK1 ATG13 | ULK1-ATG13-ATG14-PIK3C3 complex |
| GO:0006497 | 8.87760174517e-05 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | protein lipidation |
| GO:0042158 | 9.44983107329e-05 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | lipoprotein biosynthetic process |
| GO:0031331 | 0.000103732974009 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | positive regulation of cellular catabolic process |
| GO:0016236 | 0.000109670539315 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | macroautophagy |
| WP:WP5087 | 0.000127149559662 | 0.8 | RB1CC1 ATG13 ULK2 ULK1 | Pleural mesothelioma |
| GO:0010506 | 0.000156571385438 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | regulation of autophagy |
| GO:0000422 | 0.000196862025642 | 0.8 | RB1CC1 ATG13 ULK2 ULK1 | autophagy of mitochondrion |
| GO:0042157 | 0.000207211791955 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | lipoprotein metabolic process |
| GO:0061709 | 0.000652677252708 | 0.6 | RB1CC1 ULK2 ULK1 | reticulophagy |
| GO:0009896 | 0.000980634650742 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | positive regulation of catabolic process |
| GO:1902554 | 0.00130803575944 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | serine/threonine protein kinase complex |
| GO:0006914 | 0.00130936938487 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | autophagy |
| GO:0061919 | 0.00130936938487 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | process utilizing autophagic mechanism |
| WP:WP2509 | 0.00135500760343 | 0.4 | ULK2 ULK1 | Nanoparticle triggered autophagic cell death |
| GO:1902911 | 0.00218060317198 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | protein kinase complex |
| GO:1903008 | 0.0022427823715 | 0.8 | RB1CC1 ATG13 ULK2 ULK1 | organelle disassembly |
| WP:WP1471 | 0.00328532749654 | 0.4 | ULK2 ULK1 | Target of rapamycin signaling |
| GO:0031329 | 0.00335071115365 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | regulation of cellular catabolic process |
| GO:0070925 | 0.0156623135541 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | organelle assembly |
| WP:WP4963 | 0.0188521857166 | 0.4 | ULK2 ULK1 | p53 transcriptional gene network |
| GO:0009894 | 0.0219433690578 | 1.0 | ATG101 ATG13 ULK2 RB1CC1 ULK1 | regulation of catabolic process |
| GO:0061695 | 0.0306592465565 | 0.8 | ATG101 ATG13 ULK1 RB1CC1 | transferase complex, transferring phosphorus-containing groups |
| GO:0048671 | 0.0468008499735 | 0.4 | ULK2 ULK1 | negative regulation of collateral sprouting |
| KEGG:04150 | 0.0484667159694 | 0.4 | ULK2 ULK1 | mTOR signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATG101 | ATG13 | 0.998 | 0.204 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG101 | RB1CC1 | 0.998 | 0.212 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG101 | ULK1 | 0.996 | 0.104482142857 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| RB1CC1 | ATG13 | 0.982 | 0.222 | bioplex_WMM bioplex3_WMM WMM_only |
| ATG101 | ULK2 | 0.975 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ULK1 | ATG13 | 0.871 | 0.146 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK1 | RB1CC1 | 0.868 | 0.312 | bioplex_WMM bioplex3_WMM WMM_only |
| ULK2 | ULK1 | 0.415 | bioplex3_WMM WMM_only | |
| ULK2 | ATG13 | 0.415 | bioplex3_WMM WMM_only | |
| ULK2 | RB1CC1 | 0.25 | bioplex3_WMM WMM_only |
Related Complexes