hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00720.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DLG3 | Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) | 5 | UniProt NCBI |
| DLG2 | Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-442982 | 0.000155497319444 | 1.0 | DLG3 DLG2 | Ras activation upon Ca2+ influx through NMDA receptor |
| REAC:R-HSA-438066 | 0.00023239159829 | 1.0 | DLG3 DLG2 | Unblocking of NMDA receptors, glutamate binding and activation |
| REAC:R-HSA-9617324 | 0.00023239159829 | 1.0 | DLG3 DLG2 | Negative regulation of NMDA receptor-mediated neuronal transmission |
| REAC:R-HSA-9620244 | 0.000261440548076 | 1.0 | DLG3 DLG2 | Long-term potentiation |
| REAC:R-HSA-442742 | 0.000394723964742 | 1.0 | DLG3 DLG2 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| REAC:R-HSA-9609736 | 0.00120125951175 | 1.0 | DLG3 DLG2 | Assembly and cell surface presentation of NMDA receptors |
| WP:WP5417 | 0.00155570330173 | 1.0 | DLG3 DLG2 | Cell lineage map for neuronal differentiation |
| KEGG:04530 | 0.00155920593969 | 1.0 | DLG3 DLG2 | Tight junction |
| KEGG:04390 | 0.001720800216 | 1.0 | DLG3 DLG2 | Hippo signaling pathway |
| REAC:R-HSA-6794361 | 0.00176856841345 | 1.0 | DLG3 DLG2 | Neurexins and neuroligins |
| REAC:R-HSA-438064 | 0.00389255927135 | 1.0 | DLG3 DLG2 | Post NMDA receptor activation events |
| REAC:R-HSA-6794362 | 0.00412665963139 | 1.0 | DLG3 DLG2 | Protein-protein interactions at synapses |
| REAC:R-HSA-442755 | 0.00539968713673 | 1.0 | DLG3 DLG2 | Activation of NMDA receptors and postsynaptic events |
| KEGG:05165 | 0.00700203931066 | 1.0 | DLG3 DLG2 | Human papillomavirus infection |
| WP:WP5420 | 0.0144418640295 | 1.0 | DLG3 DLG2 | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-112314 | 0.0211937720117 | 1.0 | DLG3 DLG2 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-112315 | 0.0350347422039 | 1.0 | DLG3 DLG2 | Transmission across Chemical Synapses |
| REAC:R-HSA-5673001 | 0.0385804228396 | 1.0 | DLG3 DLG2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0400465404229 | 1.0 | DLG3 DLG2 | MAPK1/MAPK3 signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DLG3 | DLG2 | 0.982 | 0.14 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| DLG3 | huMAP3_00720.1 huMAP3_01851.1 huMAP3_10326.1 huMAP3_14542.1 huMAP3_14614.1 |
| DLG2 | huMAP3_00720.1 huMAP3_14542.1 huMAP3_14614.1 |