hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00724.1
Complex Portal: CPX-19480
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDIN1 | CDAN1-interacting nuclease 1 (Protein HH114) | 5 | UniProt NCBI |
| PAN2 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (EC 3.1.13.4) (Inactive ubiquitin carboxyl-terminal hydrolase 52) (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 2) (PAN deadenylation complex subunit 2) | 5 | UniProt NCBI |
| UBN2 | Ubinuclein-2 | 3 | UniProt NCBI |
| IPO4 | Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4) | 5 | UniProt NCBI |
| ASF1A | Histone chaperone ASF1A (Anti-silencing function protein 1 homolog A) (hAsf1) (hAsf1a) (CCG1-interacting factor A) (CIA) (hCIA) | 5 | UniProt NCBI |
| PAN3 | PAN2-PAN3 deadenylation complex subunit PAN3 (PAB1P-dependent poly(A)-specific ribonuclease) (Poly(A)-nuclease deadenylation complex subunit 3) (PAN deadenylation complex subunit 3) | 5 | UniProt NCBI |
| HIRA | Protein HIRA (TUP1-like enhancer of split protein 1) | 5 | UniProt NCBI |
| CDAN1 | Codanin-1 | 5 | UniProt NCBI |
| ASF1B | Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II) | 5 | UniProt NCBI |
| CABIN1 | Calcineurin-binding protein cabin-1 (Calcineurin inhibitor) (CAIN) | 5 | UniProt NCBI |
| UBN1 | Ubinuclein-1 (HIRA-binding protein) (Protein VT4) (Ubiquitously expressed nuclear protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1150 | 4.03136208942e-10 | 0.363636363636 | HIRA ASF1B IPO4 ASF1A | Histone H3.3 complex |
| CORUM:6149 | 2.10621603952e-08 | 0.272727272727 | IPO4 CDAN1 ASF1A | Codanin-1-Asf1-histone H3.1-histone H4-importin-4 complex, cytosolic |
| REAC:R-HSA-2559584 | 6.11535741268e-08 | 0.363636363636 | HIRA UBN1 ASF1A CABIN1 | Formation of Senescence-Associated Heterochromatin Foci (SAHF) |
| CORUM:7383 | 8.42140472852e-08 | 0.272727272727 | HIRA UBN1 CABIN1 | OGT-HIRA complex |
| CORUM:7382 | 8.42140472852e-08 | 0.272727272727 | HIRA UBN1 CABIN1 | Prohibitin-HIRA complex |
| CORUM:2235 | 2.10448665621e-07 | 0.272727272727 | HIRA ASF1A ASF1B | ASF1-interacting protein complex |
| CORUM:1149 | 1.17706123706e-06 | 0.272727272727 | ASF1B IPO4 ASF1A | Histone H3.1 complex |
| REAC:R-HSA-2559586 | 3.3660441591e-05 | 0.363636363636 | HIRA UBN1 ASF1A CABIN1 | DNA Damage/Telomere Stress Induced Senescence |
| GO:0006334 | 0.000103844617735 | 0.454545454545 | HIRA UBN1 ASF1A CABIN1 ASF1B | nucleosome assembly |
| GO:0034728 | 0.000273639968177 | 0.454545454545 | HIRA UBN1 ASF1A CABIN1 ASF1B | nucleosome organization |
| CORUM:2236 | 0.000512126948792 | 0.181818181818 | ASF1A ASF1B | ASF1-histone containing complex |
| REAC:R-HSA-2559583 | 0.00159038796724 | 0.363636363636 | HIRA UBN1 ASF1A CABIN1 | Cellular Senescence |
| GO:0065004 | 0.00366167405381 | 0.454545454545 | HIRA UBN1 ASF1A CABIN1 ASF1B | protein-DNA complex assembly |
| GO:0006325 | 0.0178256532841 | 0.545454545455 | HIRA ASF1B UBN1 ASF1A CDAN1 CABIN1 | chromatin organization |
| GO:0031251 | 0.0257510396046 | 0.181818181818 | PAN2 PAN3 | PAN complex |
| REAC:R-HSA-429947 | 0.0364941063676 | 0.181818181818 | PAN2 PAN3 | Deadenylation of mRNA |
| GO:0071824 | 0.0423050839278 | 0.545454545455 | HIRA ASF1B UBN1 ASF1A CDAN1 CABIN1 | protein-DNA complex organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
|---|---|---|---|---|
| ASF1A | HIRA | 1.0 | 0.086 |
structurally_consistent (dimer)
|
| HIRA | ASF1B | 1.0 | 0.054 |
structurally_consistent (dimer)
|
| UBN2 | ASF1A | 1.0 | 0.09 | |
| CABIN1 | ASF1A | 1.0 | 0.032 | |
| IPO4 | ASF1A | 0.999 | 0.05 | |
| IPO4 | ASF1B | 0.999 | 0.074 | |
| CABIN1 | HIRA | 0.999 | 0.252 | |
| ASF1A | UBN1 | 0.999 | 0.07 |
structurally_consistent (dimer)
|
| ASF1A | PAN3 | 0.999 | 0.056 | |
| ASF1A | PAN2 | 0.998 | 0.068 | |
| UBN2 | HIRA | 0.998 | 0.266 | |
| CABIN1 | ASF1B | 0.997 | 0.03 | |
| ASF1A | CDAN1 | 0.997 | 0.114 | |
| UBN2 | ASF1B | 0.997 | 0.096 | |
| CABIN1 | UBN2 | 0.997 | 0.174 | |
| ASF1B | UBN1 | 0.997 | 0.036 |
structurally_consistent (dimer)
|
| PAN2 | PAN3 | 0.996 | 0.19 | |
| CDIN1 | ASF1A | 0.994 | 0.114 |
structurally_consistent (dimer)
|
| ASF1A | ASF1B | 0.991 | 0.136 |
mutually_exclusive (P49321)
|
| CDAN1 | ASF1B | 0.991 | 0.088 |
structurally_consistent (dimer)
|
| ASF1B | PAN3 | 0.983 | 0.024 | |
| CDIN1 | ASF1B | 0.982 | 0.044 |
structurally_consistent (dimer)
|
| HIRA | UBN1 | 0.975 | 0.404 |
mutually_exclusive (Q9Y294)
|
| UBN2 | UBN1 | 0.972 | 0.094 | |
| ASF1B | PAN2 | 0.951 | 0.032 | |
| CABIN1 | UBN1 | 0.884 | 0.124 | |
| CDIN1 | CDAN1 | 0.802 | 0.098 |
mutually_exclusive (Q9NVP2)
|
| IPO4 | HIRA | 0.794 | 0.144 | |
| CDAN1 | PAN2 | 0.756 | 0.09 | |
| CABIN1 | PAN2 | 0.704 | 0.088 | |
| UBN1 | PAN2 | 0.669 | 0.066 | |
| CABIN1 | CDAN1 | 0.648 | 0.068 | |
| CDAN1 | UBN1 | 0.645 | 0.04 |
mutually_exclusive (Q9NVP2)
|
| CDIN1 | UBN1 | 0.634 | 0.122 |
mutually_exclusive (Q9NVP2)
|
| UBN2 | CDAN1 | 0.634 | 0.072 | |
| CDAN1 | PAN3 | 0.608 | 0.096 | |
| CDIN1 | PAN2 | 0.58 | 0.104 | |
| HIRA | PAN2 | 0.564 | 0.148 | |
| CDIN1 | CABIN1 | 0.563 | 0.162 | |
| CDIN1 | UBN2 | 0.549 | 0.092 | |
| CABIN1 | PAN3 | 0.526 | 0.216 | |
| CDIN1 | PAN3 | 0.525 | 0.14 | |
| UBN1 | PAN3 | 0.511 | 0.184 | |
| IPO4 | UBN1 | 0.496 | 0.06 | |
| HIRA | PAN3 | 0.461 | 0.232 | |
| HIRA | CDAN1 | 0.425 | 0.082 | |
| CDIN1 | HIRA | 0.37 | 0.084 |
mutually_exclusive (Q9Y294)
|
| UBN2 | PAN2 | 0.34 | 0.134 | |
| IPO4 | PAN2 | 0.231 | 0.044 | |
| IPO4 | CDAN1 | 0.194 | 0.104 | |
| UBN2 | PAN3 | 0.192 | 0.098 | |
| CDIN1 | IPO4 | 0.181 | 0.07 | |
| CABIN1 | IPO4 | 0.157 | 0.052 | |
| UBN2 | IPO4 | 0.116 | 0.066 | |
| IPO4 | PAN3 | 0.073 | 0.072 |
Related Complexes