List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_00733.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
RMI2	RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18)	5	UniProt   NCBI
TOP3A	DNA topoisomerase 3-alpha (EC 5.6.2.1) (DNA topoisomerase III alpha)	5	UniProt   NCBI
CCDC69	Coiled-coil domain-containing protein 69	4	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03460	0.000895799081076	0.666666666667	RMI2 TOP3A	Fanconi anemia pathway
REAC:R-HSA-9709603	0.00188000535098	0.666666666667	RMI2 TOP3A	Impaired BRCA2 binding to PALB2
REAC:R-HSA-9704331	0.00204339075673	0.666666666667	RMI2 TOP3A	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
REAC:R-HSA-9704646	0.00204339075673	0.666666666667	RMI2 TOP3A	Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
REAC:R-HSA-9701192	0.00204339075673	0.666666666667	RMI2 TOP3A	Defective homologous recombination repair (HRR) due to BRCA1 loss of function
REAC:R-HSA-9701193	0.00204339075673	0.666666666667	RMI2 TOP3A	Defective homologous recombination repair (HRR) due to PALB2 loss of function
REAC:R-HSA-5693554	0.00239054881557	0.666666666667	RMI2 TOP3A	Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
REAC:R-HSA-5693568	0.00359505378021	0.666666666667	RMI2 TOP3A	Resolution of D-loop Structures through Holliday Junction Intermediates
REAC:R-HSA-9709570	0.00381957013228	0.666666666667	RMI2 TOP3A	Impaired BRCA2 binding to RAD51
REAC:R-HSA-5693537	0.00381957013228	0.666666666667	RMI2 TOP3A	Resolution of D-Loop Structures
REAC:R-HSA-5685938	0.00405087414568	0.666666666667	RMI2 TOP3A	HDR through Single Strand Annealing (SSA)
REAC:R-HSA-5693616	0.00504394814871	0.666666666667	RMI2 TOP3A	Presynaptic phase of homologous DNA pairing and strand exchange
REAC:R-HSA-9675136	0.00530917647079	0.666666666667	RMI2 TOP3A	Diseases of DNA Double-Strand Break Repair
REAC:R-HSA-9701190	0.00530917647079	0.666666666667	RMI2 TOP3A	Defective homologous recombination repair (HRR) due to BRCA2 loss of function
REAC:R-HSA-5693579	0.00585997836812	0.666666666667	RMI2 TOP3A	Homologous DNA Pairing and Strand Exchange
REAC:R-HSA-9675135	0.00800131218049	0.666666666667	RMI2 TOP3A	Diseases of DNA repair
GO:0031422	0.00842684400117	0.666666666667	RMI2 TOP3A	RecQ family helicase-topoisomerase III complex
WP:WP5381	0.0109522066155	0.666666666667	RMI2 TOP3A	Smith Magenis and Potocki Lupski syndrome copy number variation
REAC:R-HSA-5685942	0.0145828870271	0.666666666667	RMI2 TOP3A	HDR through Homologous Recombination (HRR)
GO:0071139	0.0210651876021	0.666666666667	RMI2 TOP3A	resolution of DNA recombination intermediates
REAC:R-HSA-69473	0.0254089329805	0.666666666667	RMI2 TOP3A	G2/M DNA damage checkpoint
REAC:R-HSA-6804756	0.0265950995478	0.666666666667	RMI2 TOP3A	Regulation of TP53 Activity through Phosphorylation
REAC:R-HSA-5693607	0.0271982878007	0.666666666667	RMI2 TOP3A	Processing of DNA double-strand break ends
CORUM:2223	0.0499402709677	0.333333333333	TOP3A	BLM-TOP3A complex



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
TOP3A	CCDC69	0.999		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116
RMI2	TOP3A	0.995	0.162	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM
RMI2	CCDC69	0.993		bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM





Related Complexes

Genename	Complexes
RMI2	huMAP3_00733.1 huMAP3_01218.1 huMAP3_04213.1 huMAP3_07537.1
TOP3A	huMAP3_00733.1 huMAP3_01218.1 huMAP3_04213.1 huMAP3_07537.1
CCDC69	huMAP3_00733.1 huMAP3_01218.1 huMAP3_07537.1 huMAP3_13411.1 huMAP3_13908.1