hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00736.1
Complex Portal: CPX-15730
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PKMYT1 | Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (EC 2.7.11.1) (Myt1 kinase) | 5 | UniProt NCBI |
| CCNB2 | G2/mitotic-specific cyclin-B2 | 5 | UniProt NCBI |
| CCNB1 | G2/mitotic-specific cyclin-B1 | 5 | UniProt NCBI |
| CCND2 | G1/S-specific cyclin-D2 | 5 | UniProt NCBI |
| CDKN1B | Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1) | 5 | UniProt NCBI |
| CDK1 | Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-69478 | 1.40306823124e-08 | 0.75 | PKMYT1 CCNB2 CDK1 | G2/M DNA replication checkpoint |
| WP:WP179 | 1.71277167836e-07 | 1.0 | PKMYT1 CDK1 CCNB2 CDKN1B | Cell cycle |
| KEGG:04110 | 4.88935083656e-07 | 1.0 | PKMYT1 CDK1 CCNB2 CDKN1B | Cell cycle |
| REAC:R-HSA-69273 | 3.2237438451e-06 | 0.75 | PKMYT1 CCNB2 CDK1 | Cyclin A/B1/B2 associated events during G2/M transition |
| CORUM:5542 | 5.12628525639e-06 | 0.5 | CDK1 CCNB2 | CCNB2-CDC2 complex |
| WP:WP707 | 1.52187722416e-05 | 0.75 | CDKN1B CCNB2 CDK1 | DNA damage response |
| WP:WP1530 | 1.52187722416e-05 | 0.75 | CDKN1B CCNB2 CDK1 | miRNA regulation of DNA damage response |
| REAC:R-HSA-69620 | 2.37268629274e-05 | 1.0 | PKMYT1 CDK1 CCNB2 CDKN1B | Cell Cycle Checkpoints |
| KEGG:04914 | 3.02781216426e-05 | 0.75 | PKMYT1 CCNB2 CDK1 | Progesterone-mediated oocyte maturation |
| CORUM:310 | 3.07520988333e-05 | 0.5 | CDK1 CCNB2 | Cell cycle kinase complex CDC2 |
| WP:WP2446 | 3.5618246416e-05 | 0.75 | CDKN1B CCNB2 CDK1 | Retinoblastoma gene in cancer |
| WP:WP5322 | 5.45528885284e-05 | 0.75 | CDKN1B CCNB2 CDK1 | CKAP4 signaling pathway map |
| KEGG:04114 | 6.21896513057e-05 | 0.75 | PKMYT1 CCNB2 CDK1 | Oocyte meiosis |
| REAC:R-HSA-2980767 | 0.000215205765992 | 0.5 | CDK1 CCNB2 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| REAC:R-HSA-69278 | 0.000302817168596 | 1.0 | PKMYT1 CDK1 CCNB2 CDKN1B | Cell Cycle, Mitotic |
| REAC:R-HSA-2514853 | 0.000563428413222 | 0.5 | CDK1 CCNB2 | Condensation of Prometaphase Chromosomes |
| REAC:R-HSA-1640170 | 0.000694680089617 | 1.0 | PKMYT1 CDK1 CCNB2 CDKN1B | Cell Cycle |
| REAC:R-HSA-162658 | 0.000798898068561 | 0.5 | CDK1 CCNB2 | Golgi Cisternae Pericentriolar Stack Reorganization |
| REAC:R-HSA-69481 | 0.000915028341188 | 0.75 | PKMYT1 CCNB2 CDK1 | G2/M Checkpoints |
| REAC:R-HSA-156711 | 0.00107524337392 | 0.5 | PKMYT1 CCNB2 | Polo-like kinase mediated events |
| REAC:R-HSA-2995383 | 0.00122873738811 | 0.5 | CDK1 CCNB2 | Initiation of Nuclear Envelope (NE) Reformation |
| REAC:R-HSA-69275 | 0.00153910156762 | 0.75 | PKMYT1 CCNB2 CDK1 | G2/M Transition |
| REAC:R-HSA-453274 | 0.00158858251537 | 0.75 | PKMYT1 CCNB2 CDK1 | Mitotic G2-G2/M phases |
| WP:WP1971 | 0.00198508114189 | 0.5 | CDKN1B CDK1 | Integrated cancer pathway |
| KEGG:04115 | 0.00502800723414 | 0.5 | CDK1 CCNB2 | p53 signaling pathway |
| WP:WP45 | 0.00511942554749 | 0.5 | CDKN1B CDK1 | G1 to S cell cycle control |
| REAC:R-HSA-3301854 | 0.00539805716719 | 0.5 | CDK1 CCNB2 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-6791312 | 0.0101102645678 | 0.5 | CDKN1B CDK1 | TP53 Regulates Transcription of Cell Cycle Genes |
| WP:WP2431 | 0.0101461159505 | 0.5 | CDKN1B CDK1 | Spinal cord injury |
| REAC:R-HSA-2980766 | 0.0110375739361 | 0.5 | CDK1 CCNB2 | Nuclear Envelope Breakdown |
| GO:0044772 | 0.0140567111088 | 1.0 | PKMYT1 CDK1 CCNB2 CDKN1B | mitotic cell cycle phase transition |
| KEGG:04068 | 0.0157117070582 | 0.5 | CDKN1B CCNB2 | FoxO signaling pathway |
| WP:WP366 | 0.0177395403747 | 0.5 | CDK1 CCNB2 | TGF beta signaling pathway |
| REAC:R-HSA-2995410 | 0.022534212454 | 0.5 | CDK1 CCNB2 | Nuclear Envelope (NE) Reassembly |
| KEGG:04218 | 0.0240987471983 | 0.5 | CDK1 CCNB2 | Cellular senescence |
| CORUM:1656 | 0.0249718442456 | 0.25 | CDKN1B | p27-cyclinE-CDK2 complex |
| CORUM:5543 | 0.0249718442456 | 0.25 | CDK1 | CCNB1-CDC2 complex |
| REAC:R-HSA-8852276 | 0.0290229039331 | 0.5 | CDK1 CCNB2 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| GO:0044770 | 0.0339527319479 | 1.0 | PKMYT1 CDK1 CCNB2 CDKN1B | cell cycle phase transition |
| REAC:R-HSA-2565942 | 0.0346321697685 | 0.5 | CDK1 CCNB2 | Regulation of PLK1 Activity at G2/M Transition |
| WP:WP5115 | 0.0365498826325 | 0.5 | CDK1 CCNB2 | Network map of SARS CoV 2 signaling pathway |
| KEGG:05203 | 0.0424327978034 | 0.5 | CDKN1B CDK1 | Viral carcinogenesis |
| KEGG:05170 | 0.0456663239038 | 0.5 | CDK1 CCNB2 | Human immunodeficiency virus 1 infection |
| WP:WP3938 | 0.049746753544 | 0.25 | CDKN1B | miR 222 in exercise induced cardiac growth |
| CORUM:5557 | 0.049938562206 | 0.25 | CDK1 | CDC2-CCNA2 complex |
| CORUM:5559 | 0.049938562206 | 0.25 | CDK1 | CDC2-CCNA2-CDK2 complex |
| CORUM:5643 | 0.049938562206 | 0.25 | CDK1 | ESPL1-CDC2 complex |
| CORUM:5550 | 0.049938562206 | 0.25 | CDK1 | CDK1-CCNB1-CCNF complex |
| CORUM:5546 | 0.049938562206 | 0.25 | CDK1 | CDC2-PCNA-CCNB1-GADD45G complex |
| CORUM:5545 | 0.049938562206 | 0.25 | CDK1 | CDC2-PCNA-CCNB1-GADD45B complex |
| CORUM:5544 | 0.049938562206 | 0.25 | CDK1 | CDC2-PCNA-CCNB1-GADD45A complex |
| CORUM:243 | 0.049938562206 | 0.25 | CDK1 | RalBP1-CDC2-CCNB1 complex |
| CORUM:5551 | 0.049938562206 | 0.25 | CDK1 | CDC2-CCNB1-PTCH1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CCNB1 | CDKN1B | 1.0 | 0.26236 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| PKMYT1 | CCNB2 | 1.0 | 0.214 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CDKN1B | CDK1 | 1.0 | 0.158 |
structurally_consistent (P20248)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| CCND2 | CDKN1B | 0.999 | 0.168 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CCNB2 | CDKN1B | 0.999 | 0.182 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCNB2 | CCNB1 | 0.999 | 0.274 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction | |
| PKMYT1 | CCNB1 | 0.999 | 0.276 |
mutually_exclusive (P61024)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| CCNB1 | CDK1 | 0.999 | 0.3 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () gupta_WMM fraction boldt_WMM | |
| CCNB2 | CDK1 | 0.998 | 0.35 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM fraction | |
| PKMYT1 | CDKN1B | 0.998 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| PKMYT1 | CDK1 | 0.993 | 0.206885714286 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () gupta_WMM |
| CCND2 | CDK1 | 0.988 | 0.25 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CCNB1 | CCND2 | 0.079 | 0.16 | bioplex3_WMM WMM_only | |
| CCNB2 | CCND2 | 0.079 | 0.084 | bioplex3_WMM WMM_only |
Related Complexes