hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00748.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAX | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | 5 | UniProt NCBI |
| MXI1 | Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11) | 5 | UniProt NCBI |
| MXD3 | Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx) | 5 | UniProt NCBI |
| MXD4 | Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4) | 3 | UniProt NCBI |
| DNAH6 | Dynein axonemal heavy chain 6 (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6) | 5 | UniProt NCBI |
| MNT | Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX) | 5 | UniProt NCBI |
| MXD1 | Max dimerization protein 1 (Max dimerizer 1) (Protein MAD) | 5 | UniProt NCBI |
| MYC | Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3052 | 2.39226645298e-05 | 0.25 | MAX MYC | MYC-MAX complex |
| CORUM:3051 | 2.39226645298e-05 | 0.25 | MAX MXD1 | MAD-MAX complex |
| CORUM:2655 | 2.39226645298e-05 | 0.25 | MAX MYC | MYC-MAX complex |
| CORUM:2653 | 0.000143457417375 | 0.25 | MAX MYC | MYC-MAX-KAT2A-TRRAP complex |
| GO:0000978 | 0.000396845715691 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0090571 | 0.00045145282213 | 0.375 | MAX MXD1 MYC | RNA polymerase II transcription repressor complex |
| GO:0000987 | 0.000458606759291 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | cis-regulatory region sequence-specific DNA binding |
| GO:0001227 | 0.000981333114653 | 0.625 | MAX MYC MXI1 MXD1 MNT | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0000981 | 0.00101403013177 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | 0.00123422340003 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO:0001217 | 0.00123641138928 | 0.625 | MAX MYC MXI1 MXD1 MNT | DNA-binding transcription repressor activity |
| WP:WP5380 | 0.00137027616359 | 0.375 | MAX MYC MXD3 | 5q35 copy number variation |
| GO:0003700 | 0.00156294453444 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | DNA-binding transcription factor activity |
| GO:0000785 | 0.00212566298582 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | chromatin |
| GO:0000976 | 0.0022345160433 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | transcription cis-regulatory region binding |
| GO:0001067 | 0.0022504485569 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | transcription regulatory region nucleic acid binding |
| GO:1990837 | 0.00309645370336 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | sequence-specific double-stranded DNA binding |
| GO:0032993 | 0.00320293753229 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | protein-DNA complex |
| GO:0043565 | 0.00508872640915 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | sequence-specific DNA binding |
| GO:0003690 | 0.00518576601331 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | double-stranded DNA binding |
| GO:0000122 | 0.00712874236673 | 0.75 | MAX MXI1 MYC MXD1 MXD4 MNT | negative regulation of transcription by RNA polymerase II |
| REAC:R-HSA-1362277 | 0.00849789009901 | 0.25 | MAX MYC | Transcription of E2F targets under negative control by DREAM complex |
| WP:WP400 | 0.0103268762936 | 0.25 | MAX MYC | p38 MAPK signaling pathway |
| GO:0070443 | 0.0131096201623 | 0.25 | MAX MXD1 | Mad-Max complex |
| GO:0071943 | 0.0131096201623 | 0.25 | MAX MYC | Myc-Max complex |
| REAC:R-HSA-1538133 | 0.0180115696713 | 0.25 | MAX MYC | G0 and Early G1 |
| GO:0140110 | 0.0199690540385 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | transcription regulator activity |
| GO:0005694 | 0.0263739534621 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | chromosome |
| WP:WP3651 | 0.0389422604329 | 0.25 | MAX MYC | Pathways affected in adenoid cystic carcinoma |
| GO:0003677 | 0.0433468686155 | 0.875 | MAX MYC MXI1 MXD4 MXD1 MXD3 MNT | DNA binding |
| KEGG:05222 | 0.0463619704146 | 0.25 | MAX MYC | Small cell lung cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAX | MXD3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAX | MXI1 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAX | MYC | 0.997 | 0.472 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| MXD3 | MNT | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAX | MXD4 | 0.995 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAX | MXD1 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MXI1 | MXD3 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAX | MNT | 0.986 | 0.092624 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| MAX | DNAH6 | 0.97 | 0.046 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| MXD4 | MYC | 0.946 | bioplex3_WMM WMM_only | |
| MXI1 | MXD4 | 0.946 | bioplex3_WMM WMM_only | |
| MXD4 | MNT | 0.946 | bioplex3_WMM WMM_only | |
| MNT | MYC | 0.795 | 0.350989295272 | bioplex3_WMM WMM_only |
| MXI1 | MNT | 0.786 | bioplex_WMM bioplex3_WMM WMM_only | |
| MXI1 | MYC | 0.757 | bioplex3_WMM WMM_only | |
| MXD4 | MXD1 | 0.415 | bioplex3_WMM WMM_only | |
| MXI1 | MXD1 | 0.415 | bioplex3_WMM WMM_only | |
| MNT | MXD1 | 0.415 | bioplex3_WMM WMM_only | |
| MXD1 | MYC | 0.21 | bioplex3_WMM WMM_only |
Related Complexes