hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00763.1
Complex Portal: CPX-24508
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FPGS | Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase) | 5 | UniProt NCBI |
| HMGCL | Hydroxymethylglutaryl-CoA lyase, mitochondrial (HL) (HMG-CoA lyase) (EC 4.1.3.4) (3-hydroxy-3-methylglutarate-CoA lyase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP311 | 0.0310970405539 | 0.5 | HMGCL | Ketone bodies synthesis and degradation |
| WP:WP5175 | 0.0310970405539 | 0.5 | HMGCL | Disorders in ketone body synthesis |
| HP:0410051 | 0.0499436884913 | 0.5 | HMGCL | Increased level of 3-hydroxy-3-methylglutaric acid in urine |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FPGS | HMGCL | 0.993 | 0.044 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| FPGS | huMAP3_00763.1 huMAP3_06745.1 huMAP3_10908.1 huMAP3_12776.1 huMAP3_13468.1 |
| HMGCL | huMAP3_00763.1 huMAP3_01270.1 huMAP3_06745.1 huMAP3_09533.1 huMAP3_10908.1 huMAP3_13468.1 |