hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00768.1
Complex Portal: CPX-24899
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP42 | Nucleoporin NUP42 (NLP-1) (NUP42 homolog) (Nucleoporin hCG1) (Nucleoporin-42) (Nucleoporin-like protein 2) | 5 | UniProt NCBI |
| NXT1 | NTF2-related export protein 1 (Protein p15) | 5 | UniProt NCBI |
| RAE1 | mRNA export factor RAE1 (Rae1 protein homolog) (mRNA-associated protein mrnp 41) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03013 | 8.70565480728e-06 | 1.0 | RAE1 NUP42 NXT1 | Nucleocytoplasmic transport |
| REAC:R-HSA-159236 | 2.55418012064e-05 | 1.0 | RAE1 NUP42 NXT1 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-72202 | 3.68984307198e-05 | 1.0 | RAE1 NUP42 NXT1 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-72203 | 0.00158225905908 | 1.0 | RAE1 NUP42 NXT1 | Processing of Capped Intron-Containing Pre-mRNA |
| REAC:R-HSA-170822 | 0.00257431960226 | 0.666666666667 | NUP42 RAE1 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 0.00257431960226 | 0.666666666667 | NUP42 RAE1 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168274 | 0.00276488364952 | 0.666666666667 | NUP42 RAE1 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 0.00276488364952 | 0.666666666667 | NUP42 RAE1 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168333 | 0.00276488364952 | 0.666666666667 | NUP42 RAE1 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-159227 | 0.00316638779295 | 0.666666666667 | NUP42 RAE1 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180910 | 0.00316638779295 | 0.666666666667 | NUP42 RAE1 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-180746 | 0.00316638779295 | 0.666666666667 | NUP42 RAE1 | Nuclear import of Rev protein |
| REAC:R-HSA-159230 | 0.0033773260227 | 0.666666666667 | NUP42 RAE1 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-4085377 | 0.0033773260227 | 0.666666666667 | NUP42 RAE1 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-165054 | 0.0033773260227 | 0.666666666667 | NUP42 RAE1 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-3301854 | 0.00359505378021 | 0.666666666667 | NUP42 RAE1 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 0.00381957013228 | 0.666666666667 | NUP42 RAE1 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 0.00381957013228 | 0.666666666667 | NUP42 RAE1 | Interactions of Rev with host cellular proteins |
| WP:WP3998 | 0.00384048220995 | 0.666666666667 | NUP42 RAE1 | Prader Willi and Angelman syndrome |
| REAC:R-HSA-3232142 | 0.00405087414568 | 0.666666666667 | NUP42 RAE1 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 0.00453384142373 | 0.666666666667 | NUP42 RAE1 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 0.00478550282195 | 0.666666666667 | NUP42 RAE1 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.00504394814871 | 0.666666666667 | NUP42 RAE1 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.00530917647079 | 0.666666666667 | NUP42 RAE1 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4615885 | 0.00585997836812 | 0.666666666667 | NUP42 RAE1 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 0.00614555007695 | 0.666666666667 | NUP42 RAE1 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 0.00735562020533 | 0.666666666667 | NUP42 RAE1 | Nuclear Envelope Breakdown |
| KEGG:05164 | 0.00780874825616 | 0.666666666667 | NXT1 RAE1 | Influenza A |
| REAC:R-HSA-191859 | 0.00867409880878 | 0.666666666667 | NUP42 RAE1 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.00867409880878 | 0.666666666667 | NUP42 RAE1 | Metabolism of non-coding RNA |
| GO:0005643 | 0.00883160549414 | 1.0 | RAE1 NUP42 NXT1 | nuclear pore |
| REAC:R-HSA-6784531 | 0.0101009261622 | 0.666666666667 | NUP42 RAE1 | tRNA processing in the nucleus |
| REAC:R-HSA-3371453 | 0.0141416283812 | 0.666666666667 | NUP42 RAE1 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.0141416283812 | 0.666666666667 | NUP42 RAE1 | Glycolysis |
| REAC:R-HSA-4551638 | 0.0145828870271 | 0.666666666667 | NUP42 RAE1 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-1169408 | 0.0145828870271 | 0.666666666667 | NUP42 RAE1 | ISG15 antiviral mechanism |
| REAC:R-HSA-5619102 | 0.0164154902665 | 0.666666666667 | NUP42 RAE1 | SLC transporter disorders |
| REAC:R-HSA-3108214 | 0.0168905285744 | 0.666666666667 | NUP42 RAE1 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.017372320015 | 0.666666666667 | NUP42 RAE1 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-70326 | 0.0209338694285 | 0.666666666667 | NUP42 RAE1 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.0242497192193 | 0.666666666667 | NUP42 RAE1 | Cellular response to heat stress |
| REAC:R-HSA-8953854 | 0.0247774527734 | 1.0 | RAE1 NUP42 NXT1 | Metabolism of RNA |
| REAC:R-HSA-5578749 | 0.0278082114556 | 0.666666666667 | NUP42 RAE1 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-9610379 | 0.0329299631783 | 0.666666666667 | NUP42 RAE1 | HCMV Late Events |
| REAC:R-HSA-72306 | 0.0329299631783 | 0.666666666667 | NUP42 RAE1 | tRNA processing |
| KEGG:05014 | 0.0393573532881 | 0.666666666667 | NXT1 RAE1 | Amyotrophic lateral sclerosis |
| REAC:R-HSA-9705671 | 0.0421708333427 | 0.666666666667 | NUP42 RAE1 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| GO:0051168 | 0.0449053607901 | 1.0 | RAE1 NUP42 NXT1 | nuclear export |
| REAC:R-HSA-211000 | 0.0468187221283 | 0.666666666667 | NUP42 RAE1 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.0484217025219 | 0.666666666667 | NUP42 RAE1 | HCMV Early Events |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NUP42 | NXT1 | 0.998 | 0.16 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NUP42 | RAE1 | 0.994 | 0.522 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| NXT1 | RAE1 | 0.994 | 0.242 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes