hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00776.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MUS81 | Crossover junction endonuclease MUS81 (EC 3.1.22.-) | 5 | UniProt NCBI |
| EME1 | Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03440 | 0.000126804361689 | 1.0 | MUS81 EME1 | Homologous recombination |
| KEGG:03460 | 0.000191181960701 | 1.0 | MUS81 EME1 | Fanconi anemia pathway |
| REAC:R-HSA-5693568 | 0.000902226205124 | 1.0 | MUS81 EME1 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 0.000958615342944 | 1.0 | MUS81 EME1 | Resolution of D-Loop Structures |
| REAC:R-HSA-6783310 | 0.00101671324252 | 1.0 | MUS81 EME1 | Fanconi Anemia Pathway |
| GO:0072429 | 0.0028092043205 | 1.0 | MUS81 EME1 | response to intra-S DNA damage checkpoint signaling |
| GO:0048476 | 0.0028092043205 | 1.0 | MUS81 EME1 | Holliday junction resolvase complex |
| GO:1905347 | 0.0028092043205 | 1.0 | MUS81 EME1 | endodeoxyribonuclease complex |
| REAC:R-HSA-5685942 | 0.00366529395832 | 1.0 | MUS81 EME1 | HDR through Homologous Recombination (HRR) |
| GO:0008821 | 0.00983221512175 | 1.0 | MUS81 EME1 | crossover junction DNA endonuclease activity |
| GO:0072402 | 0.00983221512175 | 1.0 | MUS81 EME1 | response to DNA integrity checkpoint signaling |
| GO:0072396 | 0.00983221512175 | 1.0 | MUS81 EME1 | response to cell cycle checkpoint signaling |
| GO:0072423 | 0.00983221512175 | 1.0 | MUS81 EME1 | response to DNA damage checkpoint signaling |
| REAC:R-HSA-5693567 | 0.0128208394262 | 1.0 | MUS81 EME1 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.0141075370256 | 1.0 | MUS81 EME1 | Homology Directed Repair |
| GO:0016889 | 0.016855225923 | 1.0 | MUS81 EME1 | DNA endonuclease activity, producing 3'-phosphomonoesters |
| GO:0000712 | 0.0210690324038 | 1.0 | MUS81 EME1 | resolution of meiotic recombination intermediates |
| REAC:R-HSA-5693532 | 0.0211937720117 | 1.0 | MUS81 EME1 | DNA Double-Strand Break Repair |
| GO:0031573 | 0.0309012475255 | 1.0 | MUS81 EME1 | mitotic intra-S DNA damage checkpoint signaling |
| GO:0016894 | 0.0426062655276 | 1.0 | MUS81 EME1 | endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters |
| CORUM:13 | 0.0499419797295 | 0.5 | MUS81 | MUS81-CDS1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MUS81 | EME1 | 1.0 | 0.238 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| MUS81 | huMAP3_00776.1 huMAP3_09050.1 |
| EME1 | huMAP3_00776.1 huMAP3_06677.1 huMAP3_07717.1 huMAP3_09525.1 |