hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00791.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GBP3 | Guanylate-binding protein 3 (EC 3.6.5.-) (GTP-binding protein 3) (GBP-3) (Guanine nucleotide-binding protein 3) | 5 | UniProt NCBI |
| GBP5 | Guanylate-binding protein 5 (EC 3.6.5.-) (GBP-TA antigen) (GTP-binding protein 5) (GBP-5) (Guanine nucleotide-binding protein 5) | 5 | UniProt NCBI |
| GBP1 | Guanylate-binding protein 1 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 1) (GBP-1) (HuGBP-1) (hGBP1) (Guanine nucleotide-binding protein 1) (Interferon-induced guanylate-binding protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0140639 | 9.61200410764e-07 | 1.0 | GBP3 GBP5 GBP1 | positive regulation of pyroptosis |
| GO:0051715 | 1.92240082153e-06 | 1.0 | GBP3 GBP5 GBP1 | cytolysis in another organism |
| GO:0019835 | 3.36420143768e-06 | 1.0 | GBP3 GBP5 GBP1 | cytolysis |
| KEGG:04621 | 2.65416687338e-05 | 1.0 | GBP3 GBP5 GBP1 | NOD-like receptor signaling pathway |
| REAC:R-HSA-877300 | 3.28021305227e-05 | 1.0 | GBP3 GBP5 GBP1 | Interferon gamma signaling |
| GO:0070269 | 0.000148024863258 | 1.0 | GBP3 GBP5 GBP1 | pyroptosis |
| REAC:R-HSA-913531 | 0.000409665014874 | 1.0 | GBP3 GBP5 GBP1 | Interferon Signaling |
| GO:0031640 | 0.00110345807156 | 1.0 | GBP3 GBP5 GBP1 | killing of cells of another organism |
| GO:0141061 | 0.00110345807156 | 1.0 | GBP3 GBP5 GBP1 | disruption of cell in another organism |
| GO:0141060 | 0.00145910222354 | 1.0 | GBP3 GBP5 GBP1 | disruption of anatomical structure in another organism |
| GO:0071346 | 0.00381702295119 | 1.0 | GBP3 GBP5 GBP1 | cellular response to type II interferon |
| GO:0034341 | 0.00789722257484 | 1.0 | GBP3 GBP5 GBP1 | response to type II interferon |
| REAC:R-HSA-1280215 | 0.01747853546 | 1.0 | GBP3 GBP5 GBP1 | Cytokine Signaling in Immune system |
| GO:0001906 | 0.030542143052 | 1.0 | GBP3 GBP5 GBP1 | cell killing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GBP3 | GBP1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GBP5 | GBP1 | 0.987 | 0.21 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GBP5 | GBP3 | 0.868 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes