hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00802.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
OSBP	Oxysterol-binding protein 1	5	UniProt NCBI
OSBP2	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (ORP-4) (OSBP-related protein 4)	5	UniProt NCBI
SLC22A15	Solute carrier family 22 member 15 (Fly-like putative transporter 1) (Flipt 1)	5	UniProt NCBI
VAPA	Vesicle-associated membrane protein-associated protein A (VAMP-A) (VAMP-associated protein A) (VAP-A) (33 kDa VAMP-associated protein) (VAP-33)	5	UniProt NCBI
ACBD4	Acyl-CoA-binding domain-containing protein 4	5	UniProt NCBI
PITPNM3	Membrane-associated phosphatidylinositol transfer protein 3 (Phosphatidylinositol transfer protein, membrane-associated 3) (PITPnm 3) (Pyk2 N-terminal domain-interacting receptor 1) (NIR-1)	5	UniProt NCBI
OSBPL6	Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6)	5	UniProt NCBI
PRRT4	Proline-rich transmembrane protein 4	3	UniProt NCBI
ZFPL1	Zinc finger protein-like 1 (Zinc finger protein MCG4)	5	UniProt NCBI
PITPNM2	Membrane-associated phosphatidylinositol transfer protein 2 (Phosphatidylinositol transfer protein, membrane-associated 2) (PITPnm 2) (Pyk2 N-terminal domain-interacting receptor 3) (NIR-3)	5	UniProt NCBI
DOP1A	Protein dopey-1	3	UniProt NCBI
VAPB	Vesicle-associated membrane protein-associated protein B/C (VAMP-B/VAMP-C) (VAMP-associated protein B/C) (VAP-B/VAP-C)	5	UniProt NCBI
OSBPL3	Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3)	5	UniProt NCBI
PITPNM1	Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)	5	UniProt NCBI
USP20	Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)	5	UniProt NCBI
OSBPL9	Oxysterol-binding protein-related protein 9 (ORP-9) (OSBP-related protein 9)	5	UniProt NCBI
OSBPL2	Oxysterol-binding protein-related protein 2 (ORP-2) (OSBP-related protein 2)	5	UniProt NCBI
OSBPL11	Oxysterol-binding protein-related protein 11 (ORP-11) (OSBP-related protein 11)	5	UniProt NCBI
USP33	Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0005319	2.65712503994e-12	0.526315789474	OSBPL6 PITPNM2 OSBPL3 OSBP OSBPL9 PITPNM1 PITPNM3 OSBP2 OSBPL2 OSBPL11	lipid transporter activity
GO:0015248	5.79319335779e-11	0.368421052632	OSBPL6 OSBPL3 OSBPL9 OSBP OSBPL11 OSBP2 OSBPL2	sterol transporter activity
GO:0032934	5.45568000133e-09	0.368421052632	OSBPL6 OSBPL3 OSBPL9 OSBP OSBPL11 OSBP2 OSBPL2	sterol binding
REAC:R-HSA-556833	1.05932904943e-08	0.578947368421	PITPNM2 OSBPL6 VAPA OSBP OSBPL9 ACBD4 VAPB OSBPL3 PITPNM3 OSBPL2 PITPNM1	Metabolism of lipids
REAC:R-HSA-192105	1.25960226141e-08	0.263157894737	OSBPL6 OSBPL9 OSBP OSBPL2 OSBPL3	Synthesis of bile acids and bile salts
GO:0005496	5.32326883509e-08	0.368421052632	OSBPL6 OSBPL3 OSBPL9 OSBP OSBPL11 OSBP2 OSBPL2	steroid binding
REAC:R-HSA-194068	7.30406797017e-08	0.263157894737	OSBPL6 OSBPL9 OSBP OSBPL2 OSBPL3	Bile acid and bile salt metabolism
GO:0097038	6.41719988505e-07	0.263157894737	OSBP2 OSBPL2 OSBP OSBPL3 OSBPL6	perinuclear endoplasmic reticulum
GO:0006699	2.72004772119e-06	0.263157894737	OSBPL6 OSBPL9 OSBP OSBPL2 OSBPL3	bile acid biosynthetic process
REAC:R-HSA-1483226	5.56810784361e-06	0.157894736842	PITPNM3 PITPNM1 PITPNM2	Synthesis of PI
GO:0008526	7.11571763915e-06	0.210526315789	PITPNM3 OSBPL2 PITPNM1 PITPNM2	phosphatidylinositol transfer activity
GO:0008289	9.04690914013e-06	0.526315789474	OSBPL6 PITPNM2 OSBPL3 OSBP OSBPL9 ACBD4 PITPNM1 OSBP2 OSBPL2 OSBPL11	lipid binding
GO:0008206	1.01027997921e-05	0.263157894737	OSBPL6 OSBPL9 OSBP OSBPL2 OSBPL3	bile acid metabolic process
GO:0005215	2.22348489939e-05	0.578947368421	PITPNM2 OSBPL2 OSBPL6 OSBPL3 OSBP SLC22A15 PITPNM1 OSBP2 PITPNM3 OSBPL9 OSBPL11	transporter activity
GO:0120013	5.86672405136e-05	0.263157894737	PITPNM3 OSBPL2 OSBP PITPNM1 PITPNM2	lipid transfer activity
REAC:R-HSA-8957322	0.000118342580531	0.263157894737	OSBPL6 OSBPL9 OSBP OSBPL2 OSBPL3	Metabolism of steroids
GO:0008610	0.000241937825687	0.473684210526	OSBPL6 PITPNM2 VAPA OSBP OSBPL9 PITPNM1 OSBPL3 PITPNM3 OSBPL2	lipid biosynthetic process
GO:0120014	0.000487676172092	0.210526315789	PITPNM3 OSBPL2 PITPNM1 PITPNM2	phospholipid transfer activity
REAC:R-HSA-1430728	0.000720125367874	0.578947368421	PITPNM2 OSBPL6 VAPA OSBP OSBPL9 ACBD4 VAPB OSBPL3 PITPNM3 OSBPL2 PITPNM1	Metabolism
GO:0010876	0.000880351106544	0.368421052632	OSBPL6 VAPA OSBPL11 OSBP VAPB OSBPL2 PITPNM1	lipid localization
GO:0006629	0.00186188944793	0.526315789474	PITPNM2 OSBPL6 VAPA OSBP OSBPL9 ACBD4 PITPNM1 OSBPL3 PITPNM3 OSBPL2	lipid metabolic process
GO:0030301	0.00208502276371	0.263157894737	VAPB VAPA OSBPL2 OSBP OSBPL6	cholesterol transport
GO:0015918	0.00252442662788	0.263157894737	VAPB VAPA OSBPL2 OSBP OSBPL6	sterol transport
REAC:R-HSA-1660661	0.00325350769026	0.157894736842	VAPA OSBP VAPB	Sphingolipid de novo biosynthesis
GO:0006694	0.00694607421787	0.263157894737	OSBPL6 OSBPL9 OSBP OSBPL2 OSBPL3	steroid biosynthetic process
GO:0015485	0.00732075431576	0.210526315789	OSBP2 OSBPL2 OSBPL3 OSBPL6	cholesterol binding
GO:0005548	0.0110644348717	0.210526315789	PITPNM3 OSBPL2 PITPNM1 PITPNM2	phospholipid transporter activity
GO:0006869	0.0118611800979	0.315789473684	OSBPL6 VAPA OSBP VAPB OSBPL2 PITPNM1	lipid transport
GO:0048471	0.0165509739057	0.368421052632	OSBPL6 USP33 OSBPL3 OSBP VAPA OSBP2 OSBPL2	perinuclear region of cytoplasm
REAC:R-HSA-428157	0.0327497194068	0.157894736842	VAPA OSBP VAPB	Sphingolipid metabolism
GO:0015914	0.0333552136082	0.210526315789	VAPA OSBPL2 OSBP PITPNM1	phospholipid transport
GO:0072330	0.0378150770903	0.263157894737	OSBPL6 OSBPL9 OSBP OSBPL2 OSBPL3	monocarboxylic acid biosynthetic process
GO:0043178	0.0385685136688	0.210526315789	OSBP2 OSBPL2 OSBPL3 OSBPL6	alcohol binding
GO:1901617	0.0420398752241	0.263157894737	OSBPL6 OSBPL9 OSBP OSBPL2 OSBPL3	organic hydroxy compound biosynthetic process

Edges

Protein 1	Protein 2	Score	ProteomeHD
VAPA	VAPB	1.0	0.746
VAPB	OSBPL9	0.999	0.11
VAPB	OSBPL11	0.999	0.104
VAPA	OSBPL3	0.999	0.08
OSBPL6	VAPB	0.999	0.136810810811
VAPA	ZFPL1	0.999	0.17
VAPB	OSBPL2	0.999	0.072
VAPA	OSBPL6	0.999	0.140194444444
PITPNM2	VAPB	0.999	0.099
VAPB	OSBPL3	0.999	0.066
VAPA	OSBPL2	0.999	0.074
OSBP	VAPB	0.998	0.206
PITPNM3	VAPB	0.998
OSBP2	VAPB	0.998	0.144810810811
VAPA	OSBPL9	0.998	0.106
OSBPL9	OSBPL11	0.997	0.428
VAPA	OSBPL11	0.997	0.068
SLC22A15	VAPB	0.997
VAPA	OSBP2	0.997	0.142
ZFPL1	OSBPL3	0.996	0.086
VAPB	USP33	0.995	0.288
PITPNM1	VAPB	0.992	0.096
VAPA	OSBP	0.992	0.126
VAPA	PITPNM3	0.992
VAPB	USP20	0.992	0.246
USP20	USP33	0.988	0.124
OSBPL6	OSBPL3	0.985	0.082
VAPA	PITPNM1	0.983	0.11
ZFPL1	OSBPL2	0.983	0.026
ACBD4	VAPB	0.98	0.2
ZFPL1	PITPNM3	0.979
PRRT4	VAPB	0.975
ZFPL1	OSBPL6	0.96	0.108
DOP1A	VAPB	0.958	0.14
SLC22A15	VAPA	0.957
VAPA	PITPNM2	0.944	0.104363095238
OSBP	OSBP2	0.94	0.122
OSBP	USP33	0.938	0.182
PITPNM3	OSBPL3	0.909
SLC22A15	OSBPL2	0.904
PITPNM1	PRRT4	0.902
OSBP2	PRRT4	0.902
PRRT4	OSBPL2	0.902
SLC22A15	PRRT4	0.902
SLC22A15	PITPNM1	0.902
PRRT4	PITPNM2	0.902
SLC22A15	PITPNM2	0.902
PITPNM3	PRRT4	0.902
PITPNM1	OSBP2	0.897	0.108
OSBP2	PITPNM2	0.897	0.082
PRRT4	OSBPL9	0.892
PRRT4	OSBPL11	0.892
VAPA	USP33	0.89	0.158
SLC22A15	ZFPL1	0.889
PITPNM1	PITPNM2	0.881	0.086
OSBP2	OSBPL9	0.862	0.138
PITPNM3	PITPNM2	0.843
PITPNM1	PITPNM3	0.843
OSBP	OSBPL9	0.821	0.104
PITPNM3	USP33	0.818
PITPNM1	OSBPL2	0.797	0.088
PITPNM2	OSBPL2	0.797	0.086
PITPNM3	OSBPL2	0.793
PITPNM3	OSBP2	0.778
OSBPL9	USP33	0.778	0.296
PITPNM1	OSBPL11	0.772	0.044
PITPNM2	OSBPL9	0.772	0.062
PITPNM2	OSBPL11	0.772	0.07
PITPNM1	OSBPL9	0.772	0.056
OSBP	OSBPL11	0.769	0.088
SLC22A15	OSBPL11	0.768
VAPA	ACBD4	0.75	0.0812
OSBPL3	USP33	0.747	0.068
PITPNM2	USP20	0.739	0.066
PITPNM1	USP20	0.739	0.086
PITPNM1	OSBPL6	0.737	0.054
OSBP2	OSBPL6	0.737	0.138
OSBPL6	PITPNM2	0.737	0.048
OSBP	PITPNM2	0.731	0.088
PITPNM1	OSBP	0.731	0.102
PRRT4	USP20	0.73
SLC22A15	OSBP2	0.722
PITPNM2	OSBPL3	0.72	0.03
PITPNM1	OSBPL3	0.72	0.028
SLC22A15	PITPNM3	0.717
OSBP2	OSBPL11	0.716	0.128
SLC22A15	USP20	0.715
OSBP2	OSBPL3	0.714	0.07
OSBPL3	OSBPL11	0.712	0.076
OSBPL2	OSBPL11	0.701	0.026
PITPNM2	USP33	0.699	0.064
PITPNM1	USP33	0.699	0.054
USP20	OSBPL9	0.698	0.322
SLC22A15	OSBPL9	0.697
OSBPL6	PRRT4	0.696
OSBP	PRRT4	0.696
VAPA	USP20	0.693	0.228
USP20	OSBPL2	0.688	0.08
OSBPL9	OSBPL2	0.681	0.056
OSBP	PITPNM3	0.677
PRRT4	USP33	0.675
SLC22A15	USP33	0.663
OSBPL6	USP33	0.657	0.142
OSBP	OSBPL6	0.653	0.148
OSBPL6	OSBPL9	0.651	0.072
PITPNM3	OSBPL6	0.644
OSBPL11	USP33	0.63	0.074
PITPNM3	OSBPL11	0.625
OSBP2	USP33	0.614	0.088
PITPNM3	OSBPL9	0.611
PITPNM3	USP20	0.611
OSBPL6	OSBPL11	0.61	0.084
USP20	OSBPL11	0.609	0.218
OSBP2	OSBPL2	0.594	0.1
OSBPL2	USP33	0.572	0.058
PITPNM1	ACBD4	0.571	0.052
ACBD4	PITPNM2	0.571	0.136
ZFPL1	VAPB	0.567	0.096
PITPNM1	ZFPL1	0.563	0.034
ZFPL1	PITPNM2	0.563	0.11
OSBPL6	OSBPL2	0.551	0.122
OSBP2	USP20	0.548	0.112
OSBPL3	OSBPL2	0.543	0.036
OSBPL3	OSBPL9	0.534	0.064
OSBP	OSBPL3	0.509	0.082
DOP1A	PITPNM2	0.502	0.11
PITPNM1	DOP1A	0.502	0.056
PITPNM3	ACBD4	0.502
OSBP	OSBPL2	0.477	0.052
ZFPL1	OSBP2	0.475	0.158
OSBPL3	USP20	0.463	0.058
ZFPL1	OSBPL11	0.459	0.052
OSBPL6	USP20	0.457	0.168
OSBP	USP20	0.441	0.282
ZFPL1	OSBPL9	0.414	0.112
PRRT4	OSBPL3	0.356
SLC22A15	OSBPL6	0.343
OSBP2	ACBD4	0.335	0.072
DOP1A	ACBD4	0.333	0.046
SLC22A15	OSBP	0.323
DOP1A	PITPNM3	0.32
DOP1A	OSBPL2	0.303	0.134
DOP1A	OSBP2	0.303	0.086
OSBP	DOP1A	0.259	0.204
SLC22A15	OSBPL3	0.245
OSBP	ACBD4	0.234	0.092
ACBD4	OSBPL3	0.234	0.066
OSBP	ZFPL1	0.227	0.11
DOP1A	OSBPL3	0.22	0.062
ACBD4	PRRT4	0.214
DOP1A	PRRT4	0.214
SLC22A15	ACBD4	0.214
DOP1A	OSBPL6	0.213	0.066
ACBD4	OSBPL6	0.202	0.06
ACBD4	USP20	0.202	0.112
ACBD4	OSBPL9	0.202	0.084
ACBD4	OSBPL2	0.202	0.122
ACBD4	OSBPL11	0.202	0.094
VAPA	PRRT4	0.188
DOP1A	USP33	0.165	0.07
DOP1A	USP20	0.164	0.132
DOP1A	OSBPL11	0.164	0.076
DOP1A	OSBPL9	0.164	0.066
ZFPL1	USP20	0.157	0.106
ZFPL1	ACBD4	0.157	0.068
VAPA	DOP1A	0.155	0.0701944444444
SLC22A15	DOP1A	0.146
ACBD4	USP33	0.144	0.096
ZFPL1	USP33	0.07	0.210255813953

Related Complexes

Genename	Complexes
OSBP	huMAP3_00112.1 huMAP3_00802.1 huMAP3_00862.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_05953.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_08942.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_12065.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_13964.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14791.1 huMAP3_14847.1 huMAP3_15032.1
OSBP2	huMAP3_00802.1 huMAP3_00862.1 huMAP3_01422.1 huMAP3_03016.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_08942.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_12614.1 huMAP3_12946.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1 huMAP3_14847.1
SLC22A15	huMAP3_00112.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11633.1 huMAP3_11729.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
VAPA	huMAP3_00112.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_14473.1
ACBD4	huMAP3_00802.1 huMAP3_01422.1 huMAP3_02416.1 huMAP3_02444.1 huMAP3_06849.1 huMAP3_08743.1 huMAP3_11485.1
PITPNM3	huMAP3_00750.1 huMAP3_00802.1 huMAP3_02032.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11833.1 huMAP3_12915.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
OSBPL6	huMAP3_00802.1 huMAP3_02032.1 huMAP3_03632.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08017.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10464.1 huMAP3_11944.1 huMAP3_12915.1
PRRT4	huMAP3_00802.1 huMAP3_01083.1 huMAP3_01422.1 huMAP3_03470.1 huMAP3_06849.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
ZFPL1	huMAP3_00750.1 huMAP3_00802.1 huMAP3_02032.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_10464.1 huMAP3_11833.1 huMAP3_12915.1
PITPNM2	huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07722.1 huMAP3_08743.1 huMAP3_09375.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
DOP1A	huMAP3_00162.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07612.1 huMAP3_08201.1 huMAP3_08743.1 huMAP3_11485.1 huMAP3_12705.1 huMAP3_13513.1
VAPB	huMAP3_00802.1 huMAP3_01422.1 huMAP3_06849.1 huMAP3_07388.1 huMAP3_07722.1 huMAP3_08743.1 huMAP3_09375.1 huMAP3_10725.1 huMAP3_11485.1
OSBPL3	huMAP3_00802.1 huMAP3_02032.1 huMAP3_03632.1 huMAP3_05790.1 huMAP3_07443.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_10464.1
PITPNM1	huMAP3_00112.1 huMAP3_00443.1 huMAP3_00802.1 huMAP3_01422.1 huMAP3_02032.1 huMAP3_08362.1 huMAP3_08743.1 huMAP3_08783.1 huMAP3_10293.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14473.1 huMAP3_14729.1
USP20	huMAP3_00802.1 huMAP3_01012.1 huMAP3_01370.1 huMAP3_01422.1 huMAP3_04282.1 huMAP3_06835.1 huMAP3_06849.1 huMAP3_07360.1 huMAP3_10759.1 huMAP3_11328.1 huMAP3_11485.1 huMAP3_12653.1 huMAP3_13990.1 huMAP3_14051.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14623.1 huMAP3_14791.1 huMAP3_15032.1
OSBPL9	huMAP3_00802.1 huMAP3_01422.1 huMAP3_01764.1 huMAP3_01831.1 huMAP3_03880.1 huMAP3_08937.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_12460.1 huMAP3_12585.1 huMAP3_13000.1 huMAP3_13169.1 huMAP3_14473.1
OSBPL2	huMAP3_00802.1 huMAP3_01468.1 huMAP3_10464.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13169.1 huMAP3_14729.1
OSBPL11	huMAP3_00802.1 huMAP3_01422.1 huMAP3_01764.1 huMAP3_01831.1 huMAP3_03880.1 huMAP3_08937.1 huMAP3_10293.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_11815.1 huMAP3_13000.1 huMAP3_14177.1 huMAP3_14856.1
USP33	huMAP3_00802.1 huMAP3_01370.1 huMAP3_01422.1 huMAP3_04282.1 huMAP3_06849.1 huMAP3_07360.1 huMAP3_08743.1 huMAP3_10759.1 huMAP3_11340.1 huMAP3_11485.1 huMAP3_11506.1 huMAP3_13964.1 huMAP3_14131.1 huMAP3_14473.1 huMAP3_14623.1 huMAP3_14791.1 huMAP3_15032.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_00802.1