hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00806.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HMGB1 | High mobility group protein B1 (High mobility group protein 1) (HMG-1) | 5 | UniProt NCBI |
| HMGB2 | High mobility group protein B2 (High mobility group protein 2) (HMG-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:280 | 5.12628525639e-06 | 1.0 | HMGB1 HMGB2 | HMGB1-HMGB2-HSC70-ERP60-GAPDH complex |
| REAC:R-HSA-140342 | 0.000133283416666 | 1.0 | HMGB1 HMGB2 | Apoptosis induced DNA fragmentation |
| HPA:0400653 | 0.00106518672821 | 1.0 | HMGB1 HMGB2 | rectum; fibroblasts[High] |
| WP:WP2446 | 0.00155570330173 | 1.0 | HMGB1 HMGB2 | Retinoblastoma gene in cancer |
| REAC:R-HSA-75153 | 0.0020095038205 | 1.0 | HMGB1 HMGB2 | Apoptotic execution phase |
| HPA:0461423 | 0.00219958050373 | 1.0 | HMGB1 HMGB2 | skin 1; eccrine glands[High] |
| HPA:0030443 | 0.00235665041111 | 1.0 | HMGB1 HMGB2 | appendix; non-germinal center cells[High] |
| HPA:0400203 | 0.00235665041111 | 1.0 | HMGB1 HMGB2 | rectum; endothelial cells[High] |
| HPA:0400243 | 0.00280198271556 | 1.0 | HMGB1 HMGB2 | rectum; peripheral nerve/ganglion[High] |
| HPA:0400652 | 0.00309987391922 | 1.0 | HMGB1 HMGB2 | rectum; fibroblasts[>=Medium] |
| HPA:0400651 | 0.00380819300345 | 1.0 | HMGB1 HMGB2 | rectum; fibroblasts[>=Low] |
| HPA:0471493 | 0.00451530848687 | 1.0 | HMGB1 HMGB2 | skin 2; vascular mural cells[High] |
| GO:0097100 | 0.00468200720083 | 1.0 | HMGB1 HMGB2 | supercoiled DNA binding |
| HPA:0461493 | 0.00512433050323 | 1.0 | HMGB1 HMGB2 | skin 1; vascular mural cells[High] |
| HPA:0481353 | 0.00552452777682 | 1.0 | HMGB1 HMGB2 | small intestine; paneth cells[High] |
| HPA:0131333 | 0.00568881928914 | 1.0 | HMGB1 HMGB2 | colon; mucosal lymphoid cells[High] |
| HPA:0151353 | 0.00619613703596 | 1.0 | HMGB1 HMGB2 | duodenum; paneth cells[High] |
| HPA:0030893 | 0.00654638487541 | 1.0 | HMGB1 HMGB2 | appendix; goblet cells[High] |
| HPA:0401333 | 0.00736964783823 | 1.0 | HMGB1 HMGB2 | rectum; mucosal lymphoid cells[High] |
| HPA:0400202 | 0.00765490123324 | 1.0 | HMGB1 HMGB2 | rectum; endothelial cells[>=Medium] |
| HPA:0031303 | 0.00804366429902 | 1.0 | HMGB1 HMGB2 | appendix; enterocytes[High] |
| HPA:0400242 | 0.00854315864049 | 1.0 | HMGB1 HMGB2 | rectum; peripheral nerve/ganglion[>=Medium] |
| HPA:0130893 | 0.00874716897996 | 1.0 | HMGB1 HMGB2 | colon; goblet cells[High] |
| HPA:0150893 | 0.00905769799226 | 1.0 | HMGB1 HMGB2 | duodenum; goblet cells[High] |
| HPA:0480893 | 0.00948016188107 | 1.0 | HMGB1 HMGB2 | small intestine; goblet cells[High] |
| HPA:0400893 | 0.00948016188107 | 1.0 | HMGB1 HMGB2 | rectum; goblet cells[High] |
| HPA:0461422 | 0.00948016188107 | 1.0 | HMGB1 HMGB2 | skin 1; eccrine glands[>=Medium] |
| HPA:0461492 | 0.00991225457647 | 1.0 | HMGB1 HMGB2 | skin 1; vascular mural cells[>=Medium] |
| HPA:0471492 | 0.0101319117266 | 1.0 | HMGB1 HMGB2 | skin 2; vascular mural cells[>=Medium] |
| HPA:0461393 | 0.0101319117266 | 1.0 | HMGB1 HMGB2 | skin 1; cells in basal layer[High] |
| HPA:0131303 | 0.010805326387 | 1.0 | HMGB1 HMGB2 | colon; enterocytes[High] |
| HPA:0481352 | 0.0112663055022 | 1.0 | HMGB1 HMGB2 | small intestine; paneth cells[>=Medium] |
| HPA:0031293 | 0.0116183587428 | 1.0 | HMGB1 HMGB2 | appendix; endocrine cells[High] |
| HPA:0401303 | 0.0116183587428 | 1.0 | HMGB1 HMGB2 | rectum; enterocytes[High] |
| HPA:0461413 | 0.0117369134239 | 1.0 | HMGB1 HMGB2 | skin 1; cells in spinous layer[High] |
| HPA:0151303 | 0.0124608793188 | 1.0 | HMGB1 HMGB2 | duodenum; enterocytes[High] |
| HPA:0461463 | 0.012955559257 | 1.0 | HMGB1 HMGB2 | skin 1; langerhans cells[High] |
| HPA:0481303 | 0.0130807337426 | 1.0 | HMGB1 HMGB2 | small intestine; enterocytes[High] |
| GO:0050786 | 0.0131096201623 | 1.0 | HMGB1 HMGB2 | RAGE receptor binding |
| GO:0033151 | 0.0131096201623 | 1.0 | HMGB1 HMGB2 | V(D)J recombination |
| HPA:0151352 | 0.0138444184647 | 1.0 | HMGB1 HMGB2 | duodenum; paneth cells[>=Medium] |
| HPA:0131293 | 0.014103794442 | 1.0 | HMGB1 HMGB2 | colon; endocrine cells[High] |
| HPA:0400201 | 0.0144973719111 | 1.0 | HMGB1 HMGB2 | rectum; endothelial cells[>=Low] |
| HPA:0481351 | 0.0148963655838 | 1.0 | HMGB1 HMGB2 | small intestine; paneth cells[>=Low] |
| HPA:0400241 | 0.0151653703677 | 1.0 | HMGB1 HMGB2 | rectum; peripheral nerve/ganglion[>=Low] |
| HPA:0471491 | 0.0158484138347 | 1.0 | HMGB1 HMGB2 | skin 2; vascular mural cells[>=Low] |
| HPA:0030442 | 0.0158484138347 | 1.0 | HMGB1 HMGB2 | appendix; non-germinal center cells[>=Medium] |
| HPA:0460183 | 0.0161258438244 | 1.0 | HMGB1 HMGB2 | skin 1; cells in granular layer[High] |
| HPA:0461421 | 0.0161258438244 | 1.0 | HMGB1 HMGB2 | skin 1; eccrine glands[>=Low] |
| HPA:0401293 | 0.0161258438244 | 1.0 | HMGB1 HMGB2 | rectum; endocrine cells[High] |
| HPA:0461491 | 0.0162654615198 | 1.0 | HMGB1 HMGB2 | skin 1; vascular mural cells[>=Low] |
| HPA:0151351 | 0.0165465023119 | 1.0 | HMGB1 HMGB2 | duodenum; paneth cells[>=Low] |
| HPA:0481293 | 0.0178409749969 | 1.0 | HMGB1 HMGB2 | small intestine; endocrine cells[High] |
| HPA:0151293 | 0.0201067535459 | 1.0 | HMGB1 HMGB2 | duodenum; endocrine cells[High] |
| HPA:0030892 | 0.0201067535459 | 1.0 | HMGB1 HMGB2 | appendix; goblet cells[>=Medium] |
| GO:0006265 | 0.0210690324038 | 1.0 | HMGB1 HMGB2 | DNA topological change |
| REAC:R-HSA-109581 | 0.0234014921954 | 1.0 | HMGB1 HMGB2 | Apoptosis |
| HPA:0130892 | 0.0238439341008 | 1.0 | HMGB1 HMGB2 | colon; goblet cells[>=Medium] |
| HPA:0471393 | 0.0240136418168 | 1.0 | HMGB1 HMGB2 | skin 2; cells in basal layer[High] |
| HPA:0150892 | 0.0243548626501 | 1.0 | HMGB1 HMGB2 | duodenum; goblet cells[>=Medium] |
| HPA:0480892 | 0.0245263757673 | 1.0 | HMGB1 HMGB2 | small intestine; goblet cells[>=Medium] |
| HPA:0400892 | 0.0245263757673 | 1.0 | HMGB1 HMGB2 | rectum; goblet cells[>=Medium] |
| HPA:0030441 | 0.0253929683598 | 1.0 | HMGB1 HMGB2 | appendix; non-germinal center cells[>=Low] |
| GO:0008301 | 0.0257510396046 | 1.0 | HMGB1 HMGB2 | DNA binding, bending |
| HPA:0460203 | 0.0268108101291 | 1.0 | HMGB1 HMGB2 | skin 1; endothelial cells[High] |
| HPA:0470203 | 0.0271712885755 | 1.0 | HMGB1 HMGB2 | skin 2; endothelial cells[High] |
| HPA:0131332 | 0.0278994670733 | 1.0 | HMGB1 HMGB2 | colon; mucosal lymphoid cells[>=Medium] |
| HPA:0031292 | 0.0293847104887 | 1.0 | HMGB1 HMGB2 | appendix; endocrine cells[>=Medium] |
| HPA:0031302 | 0.0295730740175 | 1.0 | HMGB1 HMGB2 | appendix; enterocytes[>=Medium] |
| HPA:0030891 | 0.0305239186675 | 1.0 | HMGB1 HMGB2 | appendix; goblet cells[>=Low] |
| REAC:R-HSA-5357801 | 0.0319897287616 | 1.0 | HMGB1 HMGB2 | Programmed Cell Death |
| HPA:0131302 | 0.0328673294696 | 1.0 | HMGB1 HMGB2 | colon; enterocytes[>=Medium] |
| HPA:0401302 | 0.0336677240168 | 1.0 | HMGB1 HMGB2 | rectum; enterocytes[>=Medium] |
| HPA:0401332 | 0.0336677240168 | 1.0 | HMGB1 HMGB2 | rectum; mucosal lymphoid cells[>=Medium] |
| HPA:0150891 | 0.0342743388315 | 1.0 | HMGB1 HMGB2 | duodenum; goblet cells[>=Low] |
| HPA:0401292 | 0.03468175771 | 1.0 | HMGB1 HMGB2 | rectum; endocrine cells[>=Medium] |
| HPA:0400891 | 0.0348863698499 | 1.0 | HMGB1 HMGB2 | rectum; goblet cells[>=Low] |
| HPA:0480891 | 0.0350915837902 | 1.0 | HMGB1 HMGB2 | small intestine; goblet cells[>=Low] |
| HPA:0130891 | 0.035503817072 | 1.0 | HMGB1 HMGB2 | colon; goblet cells[>=Low] |
| HPA:0131292 | 0.035503817072 | 1.0 | HMGB1 HMGB2 | colon; endocrine cells[>=Medium] |
| HPA:0470673 | 0.035503817072 | 1.0 | HMGB1 HMGB2 | skin 2; melanocytes[High] |
| HPA:0031291 | 0.0367549601274 | 1.0 | HMGB1 HMGB2 | appendix; endocrine cells[>=Low] |
| HPA:0151302 | 0.0401972584807 | 1.0 | HMGB1 HMGB2 | duodenum; enterocytes[>=Medium] |
| HPA:0481302 | 0.0408598407336 | 1.0 | HMGB1 HMGB2 | small intestine; enterocytes[>=Medium] |
| HPA:0461473 | 0.0408598407336 | 1.0 | HMGB1 HMGB2 | skin 1; lymphocytes[High] |
| HPA:0131291 | 0.0419761804968 | 1.0 | HMGB1 HMGB2 | colon; endocrine cells[>=Low] |
| HPA:0401291 | 0.0419761804968 | 1.0 | HMGB1 HMGB2 | rectum; endocrine cells[>=Low] |
| WP:WP4479 | 0.0435328773163 | 0.5 | HMGB1 | Supression of HMGB1 mediated inflammation by THBD |
| HPA:0461443 | 0.0437936177393 | 1.0 | HMGB1 HMGB2 | skin 1; fibrohistiocytic cells[High] |
| HPA:0151292 | 0.0440235054965 | 1.0 | HMGB1 HMGB2 | duodenum; endocrine cells[>=Medium] |
| HPA:0481292 | 0.044253995054 | 1.0 | HMGB1 HMGB2 | small intestine; endocrine cells[>=Medium] |
| HPA:0031301 | 0.0485057149607 | 1.0 | HMGB1 HMGB2 | appendix; enterocytes[>=Low] |
| HPA:0481291 | 0.0499662845592 | 1.0 | HMGB1 HMGB2 | small intestine; endocrine cells[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| HMGB1 | HMGB2 | 0.972 | 0.722 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
Related Complexes