hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00819.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
AP1S1	AP-1 complex subunit sigma-1A (Adaptor protein complex AP-1 subunit sigma-1A) (Adaptor-related protein complex 1 subunit sigma-1A) (Clathrin assembly protein complex 1 sigma-1A small chain) (Clathrin coat assembly protein AP19) (Golgi adaptor HA1/AP1 adaptin sigma-1A subunit) (HA1 19 kDa subunit) (Sigma 1a subunit of AP-1 clathrin) (Sigma-adaptin 1A) (Sigma1A-adaptin)	5	UniProt NCBI
AP1M1	AP-1 complex subunit mu-1 (AP-mu chain family member mu1A) (Adaptor protein complex AP-1 subunit mu-1) (Adaptor-related protein complex 1 subunit mu-1) (Clathrin assembly protein complex 1 mu-1 medium chain 1) (Clathrin coat assembly protein AP47) (Clathrin coat-associated protein AP47) (Golgi adaptor HA1/AP1 adaptin mu-1 subunit) (Mu-adaptin 1) (Mu1A-adaptin)	5	UniProt NCBI
AP1B1	AP-1 complex subunit beta-1 (Adaptor protein complex AP-1 subunit beta-1) (Adaptor-related protein complex 1 subunit beta-1) (Beta-1-adaptin) (Beta-adaptin 1) (Clathrin assembly protein complex 1 beta large chain) (Golgi adaptor HA1/AP1 adaptin beta subunit)	5	UniProt NCBI
SYNJ1	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1)	5	UniProt NCBI
NECAP1	Adaptin ear-binding coat-associated protein 1 (NECAP endocytosis-associated protein 1) (NECAP-1)	4	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0030118	5.18434107588e-09	1.0	AP1S1 NECAP1 AP1M1 SYNJ1 AP1B1	clathrin coat
CORUM:7476	1.12081835382e-08	0.6	AP1S1 AP1M1 AP1B1	AP1B1-AP1G2-AP1M-1AP1S1 complex
REAC:R-HSA-432722	1.34717770914e-07	0.8	AP1S1 AP1M1 NECAP1 AP1B1	Golgi Associated Vesicle Biogenesis
CORUM:36	1.56850139259e-07	0.6	AP1S1 AP1M1 AP1B1	AP1 adaptor complex
CORUM:144	2.35251050842e-07	0.6	AP1S1 AP1M1 AP1B1	Gamma-BAR-AP1 complex
GO:0030117	3.3271095513e-07	1.0	AP1S1 NECAP1 AP1M1 SYNJ1 AP1B1	membrane coat
GO:0048475	3.3271095513e-07	1.0	AP1S1 NECAP1 AP1M1 SYNJ1 AP1B1	coated membrane
REAC:R-HSA-164940	3.74224604281e-07	0.6	AP1S1 AP1M1 AP1B1	Nef mediated downregulation of MHC class I complex cell surface expression
REAC:R-HSA-199992	3.9023921419e-07	0.8	AP1S1 AP1M1 NECAP1 AP1B1	trans-Golgi Network Vesicle Budding
GO:0030125	3.12047922974e-06	0.8	AP1S1 AP1M1 NECAP1 AP1B1	clathrin vesicle coat
REAC:R-HSA-164938	4.14297217289e-06	0.6	AP1S1 AP1M1 AP1B1	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
REAC:R-HSA-164952	9.10580767182e-06	0.6	AP1S1 AP1M1 AP1B1	The role of Nef in HIV-1 replication and disease pathogenesis
REAC:R-HSA-199991	1.47875510738e-05	1.0	AP1S1 NECAP1 AP1M1 SYNJ1 AP1B1	Membrane Trafficking
REAC:R-HSA-432720	1.69745830215e-05	0.6	AP1S1 AP1M1 AP1B1	Lysosome Vesicle Biogenesis
REAC:R-HSA-5653656	1.94224031817e-05	1.0	AP1S1 NECAP1 AP1M1 SYNJ1 AP1B1	Vesicle-mediated transport
GO:0030120	5.18179525184e-05	0.8	AP1S1 AP1M1 NECAP1 AP1B1	vesicle coat
GO:0030121	0.000115261178119	0.6	AP1S1 AP1M1 AP1B1	AP-1 adaptor complex
GO:0030130	0.000211268761872	0.6	AP1S1 AP1M1 AP1B1	clathrin coat of trans-Golgi network vesicle
KEGG:04142	0.000278939673238	0.6	AP1S1 AP1M1 AP1B1	Lysosome
GO:0012510	0.000349481973524	0.6	AP1S1 AP1M1 AP1B1	trans-Golgi network transport vesicle membrane
GO:0030665	0.000365836607157	0.8	AP1S1 AP1M1 NECAP1 AP1B1	clathrin-coated vesicle membrane
GO:0030131	0.000783132248318	0.6	AP1S1 AP1M1 AP1B1	clathrin adaptor complex
GO:1903232	0.000783132248318	0.6	AP1S1 AP1M1 AP1B1	melanosome assembly
REAC:R-HSA-2132295	0.000802337674321	0.6	AP1S1 AP1M1 AP1B1	MHC class II antigen presentation
REAC:R-HSA-162909	0.000979250057704	0.6	AP1S1 AP1M1 AP1B1	Host Interactions of HIV factors
KEGG:05170	0.00107946278271	0.6	AP1S1 AP1M1 AP1B1	Human immunodeficiency virus 1 infection
GO:0060155	0.00127603542925	0.6	AP1S1 AP1M1 AP1B1	platelet dense granule organization
HP:0011967	0.00179436403841	0.4	AP1S1 AP1B1	Decreased circulating copper concentration
GO:0030136	0.0022427823715	0.8	AP1S1 AP1M1 NECAP1 AP1B1	clathrin-coated vesicle
HP:0010837	0.00230672366147	0.4	AP1S1 AP1B1	Decreased circulating ceruloplasmin concentration
GO:0030662	0.00243730532859	0.8	AP1S1 AP1M1 NECAP1 AP1B1	coated vesicle membrane
GO:0030140	0.00314081658857	0.6	AP1S1 AP1M1 AP1B1	trans-Golgi network transport vesicle
HP:0033144	0.0035231963033	0.4	AP1S1 AP1B1	Abnormal circulating ceruloplasmin concentration
REAC:R-HSA-162906	0.00541502775671	0.6	AP1S1 AP1M1 AP1B1	HIV Infection
HP:0010836	0.00582689447108	0.4	AP1S1 AP1B1	Abnormal circulating copper concentration
GO:0030119	0.00627040828674	0.6	AP1S1 AP1M1 AP1B1	AP-type membrane coat adaptor complex
GO:0048753	0.00683974211741	0.6	AP1S1 AP1M1 AP1B1	pigment granule organization
GO:0032438	0.00683974211741	0.6	AP1S1 AP1M1 AP1B1	melanosome organization
GO:0033363	0.00807957978043	0.6	AP1S1 AP1M1 AP1B1	secretory granule organization
HP:0001406	0.00979150178217	0.4	AP1S1 AP1B1	Intrahepatic cholestasis
HP:0031865	0.0109419445801	0.4	AP1S1 AP1B1	Abnormal liver physiology
GO:0030135	0.0130363720333	0.8	AP1S1 AP1M1 NECAP1 AP1B1	coated vesicle
GO:0030660	0.0135806930791	0.6	AP1S1 AP1M1 AP1B1	Golgi-associated vesicle membrane
GO:0012506	0.019151051638	1.0	AP1S1 NECAP1 AP1M1 SYNJ1 AP1B1	vesicle membrane
GO:0033059	0.0250826699056	0.6	AP1S1 AP1M1 AP1B1	cellular pigmentation
GO:0110010	0.0280843539964	0.4	AP1S1 AP1B1	basolateral protein secretion
GO:0016050	0.0329457298686	0.8	AP1S1 AP1M1 SYNJ1 AP1B1	vesicle organization
HP:0000348	0.0420145178298	0.6	AP1S1 SYNJ1 NECAP1	High forehead
HP:0011030	0.0448666137641	0.4	AP1S1 AP1B1	Abnormal blood transition element cation concentration
GO:0098796	0.0497243006928	1.0	AP1S1 NECAP1 AP1M1 SYNJ1 AP1B1	membrane protein complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
AP1M1	AP1B1	1.0	0.434	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction
AP1S1	SYNJ1	0.987	0.072	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
AP1S1	AP1B1	0.985	0.112	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM fraction
AP1B1	NECAP1	0.984	0.278	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only
AP1S1	AP1M1	0.98	0.248	hein_WMM bioplex3_WMM youn_WMM fraction
SYNJ1	NECAP1	0.972	0.202	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
AP1S1	NECAP1	0.968	0.048	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
AP1M1	NECAP1	0.966	0.22	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
AP1B1	SYNJ1	0.961	0.194	hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction
AP1M1	SYNJ1	0.917	0.162	hein_WMM bioplex3_WMM youn_WMM WMM_only

Related Complexes

Genename	Complexes
AP1S1	huMAP3_00819.1 huMAP3_04311.1 huMAP3_04842.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_06911.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_08695.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1M1	huMAP3_00819.1 huMAP3_04311.1 huMAP3_04842.1 huMAP3_05843.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_08695.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
AP1B1	huMAP3_00819.1 huMAP3_04311.1 huMAP3_04842.1 huMAP3_06557.1 huMAP3_06769.1 huMAP3_06911.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_08695.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1 huMAP3_13055.1
SYNJ1	huMAP3_00819.1 huMAP3_04101.1 huMAP3_06911.1 huMAP3_08320.1 huMAP3_08553.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1
NECAP1	huMAP3_00819.1 huMAP3_05849.1 huMAP3_06283.1 huMAP3_08320.1 huMAP3_08540.1 huMAP3_09107.1 huMAP3_09403.1 huMAP3_10762.1 huMAP3_10876.1 huMAP3_12376.1 huMAP3_12394.1 huMAP3_12918.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_00819.1