hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00839.1
Complex Portal: CPX-19094
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KDM2A | Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A) | 5 | UniProt NCBI |
| FBXL16 | F-box/LRR-repeat protein 16 (F-box and leucine-rich repeat protein 16) | 4 | UniProt NCBI |
| FBXW9 | F-box/WD repeat-containing protein 9 (F-box and WD-40 domain-containing protein 9) | 3 | UniProt NCBI |
| FBXL15 | F-box/LRR-repeat protein 15 (F-box only protein 37) | 5 | UniProt NCBI |
| FBXL8 | F-box/LRR-repeat protein 8 (F-box and leucine-rich repeat protein 8) (F-box protein FBL8) | 3 | UniProt NCBI |
| KDM2B | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | 5 | UniProt NCBI |
| FBXL18 | F-box/LRR-repeat protein 18 (F-box and leucine-rich repeat protein 18) | 4 | UniProt NCBI |
| FBXO31 | F-box only protein 31 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951664 | 7.23410076615e-08 | 0.75 | FBXL18 FBXL8 FBXW9 FBXO31 FBXL16 FBXL15 | Neddylation |
| REAC:R-HSA-983168 | 2.82342748503e-07 | 0.75 | FBXL18 FBXL8 FBXW9 FBXO31 FBXL16 FBXL15 | Antigen processing: Ubiquitination & Proteasome degradation |
| GO:0031146 | 3.29814637009e-07 | 0.625 | FBXL16 FBXL18 FBXL15 FBXO31 FBXL8 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process |
| REAC:R-HSA-983169 | 9.65477700289e-07 | 0.75 | FBXL18 FBXL8 FBXW9 FBXO31 FBXL16 FBXL15 | Class I MHC mediated antigen processing & presentation |
| GO:0019005 | 1.73918590284e-06 | 0.625 | FBXL16 FBXL18 FBXL15 FBXO31 FBXL8 | SCF ubiquitin ligase complex |
| REAC:R-HSA-1280218 | 4.73913973479e-05 | 0.75 | FBXL18 FBXL8 FBXW9 FBXO31 FBXL16 FBXL15 | Adaptive Immune System |
| GO:0031461 | 0.000530546258616 | 0.625 | FBXL16 FBXL18 FBXL15 FBXO31 FBXL8 | cullin-RING ubiquitin ligase complex |
| REAC:R-HSA-597592 | 0.0018209311458 | 0.75 | FBXL18 FBXL8 FBXW9 FBXO31 FBXL16 FBXL15 | Post-translational protein modification |
| GO:0000151 | 0.00642005344206 | 0.625 | FBXL16 FBXL18 FBXL15 FBXO31 FBXL8 | ubiquitin ligase complex |
| REAC:R-HSA-168256 | 0.0113619114179 | 0.75 | FBXL18 FBXL8 FBXW9 FBXO31 FBXL16 FBXL15 | Immune System |
| REAC:R-HSA-392499 | 0.0122053588899 | 0.75 | FBXL18 FBXL8 FBXW9 FBXO31 FBXL16 FBXL15 | Metabolism of proteins |
| GO:0043161 | 0.0157756507102 | 0.625 | FBXL16 FBXL18 FBXL15 FBXO31 FBXL8 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| KEGG:03083 | 0.0411542607239 | 0.25 | KDM2A KDM2B | Polycomb repressive complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FBXL15 | FBXL16 | 0.981 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXL8 | FBXL15 | 0.981 | 0.06 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL15 | FBXO31 | 0.98 | hein_WMM bioplex3_WMM WMM_only | ||
| FBXL8 | FBXO31 | 0.976 | hein_WMM bioplex3_WMM WMM_only | ||
| FBXL8 | KDM2A | 0.961 | 0.036 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL8 | FBXL16 | 0.959 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| KDM2B | FBXL15 | 0.959 | 0.142 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| KDM2B | FBXW9 | 0.956 | 0.114 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL8 | KDM2B | 0.954 | 0.056 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL8 | FBXW9 | 0.952 | 0.054 | hein_WMM bioplex3_WMM WMM_only | |
| FBXL16 | FBXW9 | 0.944 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXL15 | FBXW9 | 0.943 | 0.104 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXO31 | KDM2A | 0.932 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| KDM2B | KDM2A | 0.931 | 0.104 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXO31 | FBXW9 | 0.915 | hein_WMM bioplex3_WMM WMM_only | ||
| KDM2B | FBXO31 | 0.913 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXO31 | FBXL16 | 0.909 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXL15 | KDM2A | 0.909 | 0.094 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| KDM2B | FBXL16 | 0.892 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only | |
| FBXW9 | KDM2A | 0.88 | 0.04 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
| FBXL16 | KDM2A | 0.674 |
mutually_exclusive (P63208)
|
hein_WMM bioplex3_WMM WMM_only |
Related Complexes