hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00840.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TPH2 | Tryptophan 5-hydroxylase 2 (EC 1.14.16.4) (Neuronal tryptophan hydroxylase) (Tryptophan 5-monooxygenase 2) | 5 | UniProt NCBI |
| TPH1 | Tryptophan 5-hydroxylase 1 (EC 1.14.16.4) (Tryptophan 5-monooxygenase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-209931 | 1.02525705128e-05 | 1.0 | TPH2 TPH1 | Serotonin and melatonin biosynthesis |
| WP:WP4220 | 1.19178365112e-05 | 1.0 | TPH2 TPH1 | Neurotransmitter disorders |
| KEGG:00790 | 4.8770908342e-05 | 1.0 | TPH2 TPH1 | Folate biosynthesis |
| KEGG:00380 | 8.58367986819e-05 | 1.0 | TPH2 TPH1 | Tryptophan metabolism |
| REAC:R-HSA-209776 | 9.39818963671e-05 | 1.0 | TPH2 TPH1 | Metabolism of amine-derived hormones |
| WP:WP465 | 0.000117475817039 | 1.0 | TPH2 TPH1 | Tryptophan metabolism |
| WP:WP4698 | 0.000149398593408 | 1.0 | TPH2 TPH1 | Vitamin D sensitive calcium signaling in depression |
| GO:0004510 | 0.000468200720083 | 1.0 | TPH2 TPH1 | tryptophan 5-monooxygenase activity |
| KEGG:04726 | 0.000566717954934 | 1.0 | TPH2 TPH1 | Serotonergic synapse |
| GO:0016714 | 0.00140460216025 | 1.0 | TPH2 TPH1 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
| WP:WP706 | 0.00309012475255 | 1.0 | TPH2 TPH1 | Sudden infant death syndrome SIDS susceptibility pathways |
| WP:WP3594 | 0.00534642658633 | 1.0 | TPH2 TPH1 | Circadian rhythm genes |
| HPA:0140142 | 0.00879471121248 | 0.5 | TPH2 | dorsal raphe; neuronal projections[>=Medium] |
| HPA:0140143 | 0.00879471121248 | 0.5 | TPH2 | dorsal raphe; neuronal projections[High] |
| HPA:0140151 | 0.00879471121248 | 0.5 | TPH2 | dorsal raphe; synapses[>=Low] |
| HPA:0140152 | 0.00879471121248 | 0.5 | TPH2 | dorsal raphe; synapses[>=Medium] |
| HPA:0140153 | 0.00879471121248 | 0.5 | TPH2 | dorsal raphe; synapses[High] |
| HPA:0140133 | 0.00879471121248 | 0.5 | TPH2 | dorsal raphe; neuronal cells[High] |
| HPA:0140141 | 0.00879471121248 | 0.5 | TPH2 | dorsal raphe; neuronal projections[>=Low] |
| WP:WP5420 | 0.0144418640295 | 1.0 | TPH2 TPH1 | ADHD and autism ASD linked metabolic pathways and SNP |
| HPA:0140132 | 0.0175888206245 | 0.5 | TPH2 | dorsal raphe; neuronal cells[>=Medium] |
| HPA:0140131 | 0.0175888206245 | 0.5 | TPH2 | dorsal raphe; neuronal cells[>=Low] |
| HPA:0140000 | 0.0175888206245 | 0.5 | TPH2 | dorsal raphe |
| WP:WP1455 | 0.049750157242 | 0.5 | TPH2 | Serotonin transporter activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TPH2 | TPH1 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| TPH2 | huMAP3_00840.1 huMAP3_15100.1 |
| TPH1 | huMAP3_00840.1 huMAP3_15100.1 |