hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00843.1
Complex Portal: CPX-20729
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| YTHDF3 | YTH domain-containing family protein 3 (DF3) | 5 | UniProt NCBI |
| YTHDF1 | YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1) | 5 | UniProt NCBI |
| YTHDF2 | YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2) | 5 | UniProt NCBI |
| ZC3H7A | Zinc finger CCCH domain-containing protein 7A | 4 | UniProt NCBI |
| ZNF598 | E3 ubiquitin-protein ligase ZNF598 (EC 2.3.2.27) (Zinc finger protein 598) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:1990247 | 8.45465618902e-05 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | N6-methyladenosine-containing RNA reader activity |
| GO:0140517 | 0.000313494264121 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | protein-RNA adaptor activity |
| GO:0045948 | 0.000777349058504 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | positive regulation of translational initiation |
| GO:0034063 | 0.000998468305694 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | stress granule assembly |
| GO:0006446 | 0.0218982649712 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | regulation of translational initiation |
| GO:0000932 | 0.0258660780327 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | P-body |
| GO:0010608 | 0.0262860281498 | 1.0 | ZC3H7A YTHDF3 YTHDF1 YTHDF2 | post-transcriptional regulation of gene expression |
| GO:0010494 | 0.0280178993418 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | cytoplasmic stress granule |
| GO:0061157 | 0.0434703685672 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | mRNA destabilization |
| GO:0050779 | 0.048062454325 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | RNA destabilization |
| GO:0061014 | 0.0496619752722 | 0.75 | YTHDF3 YTHDF1 YTHDF2 | positive regulation of mRNA catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| YTHDF1 | YTHDF2 | 1.0 | 0.418 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| YTHDF3 | YTHDF1 | 0.999 | 0.596 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | |
| YTHDF3 | YTHDF2 | 0.997 | 0.612 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM | |
| YTHDF3 | ZNF598 | 0.974 | 0.15 | hein_WMM youn () bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| ZC3H7A | YTHDF3 | 0.957 | 0.188 | hein_WMM youn () bioplex3_WMM youn_WMM WMM_only | |
| ZC3H7A | ZNF598 | 0.487 | 0.052 | hein_WMM youn () youn_WMM WMM_only | |
| YTHDF2 | ZNF598 | 0.192 | 0.218 | hein_WMM youn () youn_WMM gupta_WMM fraction | |
| YTHDF1 | ZNF598 | 0.059 | 0.172 | hein_WMM youn () bioplex3_WMM youn_WMM gupta_WMM fraction | |
| ZC3H7A | YTHDF1 | 0.038 | 0.132 | youn () bioplex3_WMM youn_WMM WMM_only | |
| ZC3H7A | YTHDF2 | 0.009 | 0.196 | youn () bioplex3_HEK293 bioplex3_WMM youn_WMM WMM_only |
Related Complexes