hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00849.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ALKBH4 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (Alkylated DNA repair protein alkB homolog 4) (DNA N6-methyl adenine demethylase ALKBH4) (EC 1.14.11.51) (Lysine-specific demethylase ALKBH4) (EC 1.14.11.-) | 5 | UniProt NCBI |
| ORC2 | Origin recognition complex subunit 2 | 5 | UniProt NCBI |
| LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA) | 5 | UniProt NCBI |
| ORC3 | Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1032 | 1.53774525569e-05 | 0.5 | ORC2 ORC3 | ORC 2-4 complex (origin recognition 2-4 complex) |
| GO:0000808 | 2.15253635486e-05 | 0.75 | ORC2 ORC3 LRWD1 | origin recognition complex |
| GO:0005664 | 2.15253635486e-05 | 0.75 | ORC2 ORC3 LRWD1 | nuclear origin of replication recognition complex |
| CORUM:5251 | 3.07520988333e-05 | 0.5 | ORC2 ORC3 | Ku-ORC complex |
| CORUM:1034 | 3.07520988333e-05 | 0.5 | ORC2 ORC3 | ORC 2-5 complex (origin recognition 2-5 complex) |
| CORUM:1038 | 5.12488211613e-05 | 0.5 | ORC2 ORC3 | ORC 1-5 complex (origin recognition 1-5 complex) |
| CORUM:1033 | 7.68662167609e-05 | 0.5 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:1031 | 7.68662167609e-05 | 0.5 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| CORUM:389 | 7.68662167609e-05 | 0.5 | ORC2 ORC3 | ORC complex (origin recognition complex) |
| REAC:R-HSA-68689 | 0.000286914834749 | 0.5 | ORC2 ORC3 | CDC6 association with the ORC:origin complex |
| REAC:R-HSA-113507 | 0.000368856835097 | 0.5 | ORC2 ORC3 | E2F-enabled inhibition of pre-replication complex formation |
| GO:0006270 | 0.00190418300832 | 0.75 | ORC2 ORC3 LRWD1 | DNA replication initiation |
| WP:WP466 | 0.002190823719 | 0.5 | ORC2 ORC3 | DNA replication |
| REAC:R-HSA-113510 | 0.00236402400204 | 0.5 | ORC2 ORC3 | E2F mediated regulation of DNA replication |
| WP:WP45 | 0.00511942554749 | 0.5 | ORC2 ORC3 | G1 to S cell cycle control |
| REAC:R-HSA-68962 | 0.00539805716719 | 0.5 | ORC2 ORC3 | Activation of the pre-replicative complex |
| REAC:R-HSA-176187 | 0.00643909852192 | 0.5 | ORC2 ORC3 | Activation of ATR in response to replication stress |
| REAC:R-HSA-68616 | 0.0162811003561 | 0.5 | ORC2 ORC3 | Assembly of the ORC complex at the origin of replication |
| WP:WP179 | 0.0168573248614 | 0.5 | ORC2 ORC3 | Cell cycle |
| REAC:R-HSA-68949 | 0.0246065982605 | 0.5 | ORC2 ORC3 | Orc1 removal from chromatin |
| KEGG:04110 | 0.0280208578488 | 0.5 | ORC2 ORC3 | Cell cycle |
| REAC:R-HSA-69052 | 0.0407325822829 | 0.5 | ORC2 ORC3 | Switching of origins to a post-replicative state |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ORC2 | LRWD1 | 1.0 | 0.22 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () Malo gupta_WMM fraction |
| ALKBH4 | ORC3 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ALKBH4 | ORC2 | 0.999 | 0.02 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ORC2 | ORC3 | 0.995 | bioplex_WMM bioplex3_WMM youn_WMM Malo gupta_WMM fraction | |
| ALKBH4 | LRWD1 | 0.991 | 0.076 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| LRWD1 | ORC3 | 0.858 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes