hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00856.1
Complex Portal: CPX-15330
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GUCY2D | Retinal guanylyl cyclase 1 (RETGC-1) (EC 4.6.1.2) (CG-E) (Guanylate cyclase 2D, retinal) (Rod outer segment membrane guanylate cyclase) (ROS-GC) | 5 | UniProt NCBI |
| GUCY2F | Retinal guanylyl cyclase 2 (RETGC-2) (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (Guanylate cyclase F) (GC-F) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04744 | 2.21094784484e-05 | 1.0 | GUCY2F GUCY2D | Phototransduction |
| REAC:R-HSA-2514856 | 0.000432316723289 | 1.0 | GUCY2F GUCY2D | The phototransduction cascade |
| REAC:R-HSA-2514859 | 0.000432316723289 | 1.0 | GUCY2F GUCY2D | Inactivation, recovery and regulation of the phototransduction cascade |
| KEGG:00230 | 0.000772693757832 | 1.0 | GUCY2F GUCY2D | Purine metabolism |
| GO:0007168 | 0.00468200720083 | 1.0 | GUCY2F GUCY2D | receptor guanylyl cyclase signaling pathway |
| REAC:R-HSA-2187338 | 0.00513141154164 | 1.0 | GUCY2F GUCY2D | Visual phototransduction |
| GO:0004383 | 0.00702301080125 | 1.0 | GUCY2F GUCY2D | guanylate cyclase activity |
| GO:0006182 | 0.00983221512175 | 1.0 | GUCY2F GUCY2D | cGMP biosynthetic process |
| GO:0022400 | 0.0131096201623 | 1.0 | GUCY2F GUCY2D | regulation of rhodopsin mediated signaling pathway |
| GO:0004016 | 0.016855225923 | 1.0 | GUCY2F GUCY2D | adenylate cyclase activity |
| GO:0046068 | 0.016855225923 | 1.0 | GUCY2F GUCY2D | cGMP metabolic process |
| GO:0016056 | 0.016855225923 | 1.0 | GUCY2F GUCY2D | rhodopsin mediated signaling pathway |
| GO:0097381 | 0.0257510396046 | 1.0 | GUCY2F GUCY2D | photoreceptor disc membrane |
| GO:0007603 | 0.0309012475255 | 1.0 | GUCY2F GUCY2D | phototransduction, visible light |
| GO:0009190 | 0.0365196561665 | 1.0 | GUCY2F GUCY2D | cyclic nucleotide biosynthetic process |
| REAC:R-HSA-9709957 | 0.0367862229998 | 1.0 | GUCY2F GUCY2D | Sensory Perception |
| GO:0016849 | 0.0491610756088 | 1.0 | GUCY2F GUCY2D | phosphorus-oxygen lyase activity |
| GO:0009975 | 0.0491610756088 | 1.0 | GUCY2F GUCY2D | cyclase activity |
| HP:0003296 | 0.0499436884913 | 0.5 | GUCY2D | Hyperthreoninuria |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GUCY2D | GUCY2F | 0.983 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| GUCY2D | huMAP3_00856.1 huMAP3_03621.1 |
| GUCY2F | huMAP3_00856.1 huMAP3_03621.1 |