hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00859.1
Complex Portal: CPX-20303
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ADGRE5 | Adhesion G protein-coupled receptor E5 (Leukocyte antigen CD97) (CD antigen CD97) [Cleaved into: Adhesion G protein-coupled receptor E5 subunit alpha; Adhesion G protein-coupled receptor E5 subunit beta] | 5 | UniProt NCBI |
| ADGRE2 | Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312) | 5 | UniProt NCBI |
| MFSD8 | Major facilitator superfamily domain-containing protein 8 (Ceroid-lipofuscinosis neuronal protein 7) | 5 | UniProt NCBI |
| RAB35 | Ras-related protein Rab-35 (GTP-binding protein RAY) (Ras-related protein Rab-1C) | 5 | UniProt NCBI |
| TMPPE | Transmembrane protein with metallophosphoesterase domain (EC 3.1.-.-) | 5 | UniProt NCBI |
| ALG6 | Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase (EC 2.4.1.267) (Asparagine-linked glycosylation protein 6 homolog) (Dol-P-Glc:Man(9)GlcNAc(2)-PP-Dol alpha-1,3-glucosyltransferase) (Dolichyl-P-Glc:Man9GlcNAc2-PP-dolichyl glucosyltransferase) | 5 | UniProt NCBI |
| DRAM2 | DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP334 | 0.00117291180508 | 0.285714285714 | ADGRE5 ADGRE2 | GPCRs class B secretin like |
| WP:WP117 | 0.010518614161 | 0.285714285714 | ALG6 ADGRE2 | GPCRs other |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ADGRE5 | ADGRE2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ADGRE5 | RAB35 | 0.992 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ALG6 | ADGRE5 | 0.982 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| ADGRE5 | TMPPE | 0.981 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ADGRE5 | DRAM2 | 0.978 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ADGRE5 | MFSD8 | 0.978 | 0.092 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MFSD8 | TMPPE | 0.89 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| ALG6 | MFSD8 | 0.768 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| ALG6 | TMPPE | 0.575 | 0.134 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADGRE2 | DRAM2 | 0.516 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MFSD8 | RAB35 | 0.408 | 0.082 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ADGRE2 | RAB35 | 0.37 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RAB35 | TMPPE | 0.353 | 0.174 | bioplex_WMM bioplex3_WMM WMM_only | |
| ADGRE2 | MFSD8 | 0.231 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ADGRE2 | TMPPE | 0.169 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TMPPE | DRAM2 | 0.16 | 0.084 | bioplex_WMM bioplex3_WMM WMM_only | |
| MFSD8 | DRAM2 | 0.143 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| RAB35 | DRAM2 | 0.139 | 0.246 | bioplex_WMM bioplex3_WMM WMM_only | |
| ALG6 | DRAM2 | 0.123 | 0.154 | bioplex_WMM bioplex3_WMM WMM_only | |
| ALG6 | ADGRE2 | 0.074 | bioplex_WMM bioplex3_WMM WMM_only | ||
| ALG6 | RAB35 | 0.025 | 0.222 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes