hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00864.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SUMO2 | Small ubiquitin-related modifier 2 (SUMO-2) (HSMT3) (SMT3 homolog 2) (SUMO-3) (Sentrin-2) (Ubiquitin-like protein SMT3B) (Smt3B) | 5 | UniProt NCBI |
| SAE1 | SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed] | 5 | UniProt NCBI |
| SCRN1 | Secernin-1 | 5 | UniProt NCBI |
| UBA2 | SUMO-activating enzyme subunit 2 (EC 2.3.2.-) (Anthracycline-associated resistance ARX) (Ubiquitin-like 1-activating enzyme E1B) (Ubiquitin-like modifier-activating enzyme 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3065676 | 1.40306823124e-08 | 0.75 | SUMO2 UBA2 SAE1 | SUMO is conjugated to E1 (UBA2:SAE1) |
| REAC:R-HSA-3065678 | 2.80599241523e-08 | 0.75 | SUMO2 UBA2 SAE1 | SUMO is transferred from E1 to E2 (UBE2I, UBC9) |
| REAC:R-HSA-3215018 | 1.17833531486e-07 | 0.75 | SUMO2 UBA2 SAE1 | Processing and activation of SUMO |
| CORUM:5756 | 5.12628525639e-06 | 0.5 | SAE1 UBA2 | SUA1-UBA2 complex |
| CORUM:5755 | 1.53774525569e-05 | 0.5 | SAE1 UBA2 | SUMO1-SUA1-UBA2 complex |
| REAC:R-HSA-2990846 | 0.000986096194174 | 0.75 | SUMO2 UBA2 SAE1 | SUMOylation |
| GO:0019948 | 0.0028092043205 | 0.5 | SAE1 UBA2 | SUMO activating enzyme activity |
| GO:0031510 | 0.0028092043205 | 0.5 | SAE1 UBA2 | SUMO activating enzyme complex |
| HPA:0470673 | 0.0039388821921 | 0.75 | SUMO2 UBA2 SAE1 | skin 2; melanocytes[High] |
| GO:0016925 | 0.0100599149475 | 0.75 | SUMO2 UBA2 SAE1 | protein sumoylation |
| HPA:0460182 | 0.0136756650941 | 0.75 | SUMO2 UBA2 SAE1 | skin 1; cells in granular layer[>=Medium] |
| HPA:0470202 | 0.0206978936317 | 0.75 | SUMO2 UBA2 SAE1 | skin 2; endothelial cells[>=Medium] |
| HPA:0470672 | 0.0219529719185 | 0.75 | SUMO2 UBA2 SAE1 | skin 2; melanocytes[>=Medium] |
| KEGG:04120 | 0.0224124539322 | 0.5 | SAE1 UBA2 | Ubiquitin mediated proteolysis |
| GO:0044388 | 0.0280843539964 | 0.5 | SAE1 UBA2 | small protein activating enzyme binding |
| HPA:0460181 | 0.0284745500846 | 0.75 | SUMO2 UBA2 SAE1 | skin 1; cells in granular layer[>=Low] |
| HPA:0470181 | 0.0287284084928 | 0.75 | SUMO2 UBA2 SAE1 | skin 2; cells in granular layer[>=Low] |
| HPA:0470671 | 0.0317556027822 | 0.75 | SUMO2 UBA2 SAE1 | skin 2; melanocytes[>=Low] |
| HPA:0471493 | 0.0323185629783 | 0.5 | SUMO2 UBA2 | skin 2; vascular mural cells[High] |
| HPA:0461493 | 0.0366507731727 | 0.5 | SUMO2 UBA2 | skin 1; vascular mural cells[High] |
| HPA:0471461 | 0.0392002139957 | 0.75 | SUMO2 UBA2 SAE1 | skin 2; langerhans cells[>=Low] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SAE1 | UBA2 | 0.998 | 0.936 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| SUMO2 | UBA2 | 0.994 | 0.486 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM |
| SUMO2 | SAE1 | 0.99 | 0.408 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () gupta_WMM fraction |
| SCRN1 | UBA2 | 0.968 | 0.11 | bioplex_WMM bioplex3_WMM fraction |
| SCRN1 | SAE1 | 0.067 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only |
| SCRN1 | SUMO2 | 0.022 | 0.226 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes