hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00870.1
Complex Portal: CPX-14966
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCK1 | SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha) | 5 | UniProt NCBI |
| SH3PXD2B | SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) | 5 | UniProt NCBI |
| DOK1 | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) | 5 | UniProt NCBI |
| NHS | Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein) | 5 | UniProt NCBI |
| SEMA6A | Semaphorin-6A (Semaphorin VIA) (Sema VIA) (Semaphorin-6A-1) (SEMA6A-1) | 5 | UniProt NCBI |
| ARAP1 | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2) | 5 | UniProt NCBI |
| PIK3AP1 | Phosphoinositide 3-kinase adapter protein 1 (B-cell adapter for phosphoinositide 3-kinase) (B-cell phosphoinositide 3-kinase adapter protein 1) | 5 | UniProt NCBI |
| NCK2 | Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8849469 | 0.00136974769985 | 0.285714285714 | DOK1 ARAP1 | PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 |
| REAC:R-HSA-9006927 | 0.0390490515953 | 0.285714285714 | DOK1 ARAP1 | Signaling by Non-Receptor Tyrosine Kinases |
| REAC:R-HSA-8848021 | 0.0390490515953 | 0.285714285714 | DOK1 ARAP1 | Signaling by PTK6 |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| NCK1 | NCK2 | 1.0 | 0.084 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| ARAP1 | NCK2 | 0.999 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PIK3AP1 | NCK2 | 0.998 | 0.06 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SH3PXD2B | NCK2 | 0.997 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NCK1 | PIK3AP1 | 0.994 | 0.056 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| NHS | NCK2 | 0.988 | 0.096 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOK1 | NCK2 | 0.979 | 0.062 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| NCK1 | NHS | 0.976 | 0.15 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only | |
| SEMA6A | NCK2 | 0.965 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | ||
| NCK1 | ARAP1 | 0.959 | 0.044 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| ARAP1 | PIK3AP1 | 0.939 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| SH3PXD2B | PIK3AP1 | 0.559 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| DOK1 | PIK3AP1 | 0.513 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| NCK1 | SH3PXD2B | 0.501 | 0.07 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| NHS | PIK3AP1 | 0.49 | 0.072 | bioplex3_WMM WMM_only | |
| NCK1 | SEMA6A | 0.45 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | ||
| NHS | ARAP1 | 0.433 | 0.196 | bioplex3_WMM WMM_only | |
| SH3PXD2B | ARAP1 | 0.423 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| DOK1 | ARAP1 | 0.377 | 0.106 | bioplex_WMM bioplex3_WMM WMM_only | |
| DOK1 | NCK1 | 0.339 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only | |
| SEMA6A | PIK3AP1 | 0.324 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SEMA6A | ARAP1 | 0.233 | bioplex_WMM bioplex3_WMM WMM_only | ||
| DOK1 | SH3PXD2B | 0.215 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| DOK1 | SEMA6A | 0.188 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SH3PXD2B | SEMA6A | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SH3PXD2B | NHS | 0.131 | 0.086 | bioplex3_WMM WMM_only | |
| DOK1 | NHS | 0.131 | 0.108 | bioplex3_WMM WMM_only | |
| NHS | SEMA6A | 0.098 | bioplex3_WMM WMM_only |
Related Complexes