hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00908.1
Complex Portal: CPX-16645
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DOHH | Deoxyhypusine hydroxylase (hDOHH) (EC 1.14.99.29) (Deoxyhypusine dioxygenase) (Deoxyhypusine monooxygenase) (HEAT-like repeat-containing protein 1) | 5 | UniProt NCBI |
| CPB1 | Carboxypeptidase B (EC 3.4.17.2) (Pancreas-specific protein) (PASP) | 5 | UniProt NCBI |
| EIF5A2 | Eukaryotic translation initiation factor 5A-2 (eIF-5A-2) (eIF-5A2) (Eukaryotic initiation factor 5A isoform 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-204626 | 1.02525705128e-05 | 1.0 | EIF5A2 DOHH | Hypusine synthesis from eIF5A-lysine |
| REAC:R-HSA-163841 | 0.00113803532692 | 1.0 | EIF5A2 DOHH | Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DOHH | EIF5A2 | 0.999 | 0.168 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| CPB1 | EIF5A2 | 0.998 | 0.12 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| DOHH | CPB1 | 0.888 | bioplex3_WMM WMM_only |
Related Complexes