hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00910.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INCENP | Inner centromere protein | 5 | UniProt NCBI |
| AURKC | Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C) | 5 | UniProt NCBI |
| BIRC5 | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0032133 | 1.92240082153e-06 | 1.0 | INCENP BIRC5 AURKC | chromosome passenger complex |
| CORUM:1120 | 1.02521027753e-05 | 0.666666666667 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| CORUM:2579 | 1.02521027753e-05 | 0.666666666667 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) |
| GO:0051256 | 1.58598067776e-05 | 1.0 | INCENP BIRC5 AURKC | mitotic spindle midzone assembly |
| CORUM:1087 | 2.05032700758e-05 | 0.666666666667 | INCENP BIRC5 | BIRC5-AURKB-INCENP-EVI5 complex |
| CORUM:1118 | 2.05032700758e-05 | 0.666666666667 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1119 | 2.05032700758e-05 | 0.666666666667 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| GO:0000022 | 2.11464090368e-05 | 1.0 | INCENP BIRC5 AURKC | mitotic spindle elongation |
| GO:0051255 | 2.11464090368e-05 | 1.0 | INCENP BIRC5 AURKC | spindle midzone assembly |
| GO:0051231 | 2.74903317479e-05 | 1.0 | INCENP BIRC5 AURKC | spindle elongation |
| GO:0032467 | 0.000575182325801 | 1.0 | INCENP BIRC5 AURKC | positive regulation of cytokinesis |
| GO:0051781 | 0.000949666005835 | 1.0 | INCENP BIRC5 AURKC | positive regulation of cell division |
| GO:0008608 | 0.0018839528051 | 1.0 | INCENP BIRC5 AURKC | attachment of spindle microtubules to kinetochore |
| GO:0090307 | 0.00345936027834 | 1.0 | INCENP BIRC5 AURKC | mitotic spindle assembly |
| REAC:R-HSA-4615885 | 0.00585997836812 | 0.666666666667 | INCENP BIRC5 | SUMOylation of DNA replication proteins |
| GO:0032465 | 0.00597828207479 | 1.0 | INCENP BIRC5 AURKC | regulation of cytokinesis |
| GO:0051310 | 0.0116771431902 | 1.0 | INCENP BIRC5 AURKC | metaphase chromosome alignment |
| GO:0051303 | 0.0128843147861 | 1.0 | INCENP BIRC5 AURKC | establishment of chromosome localization |
| GO:0050000 | 0.0150763323228 | 1.0 | INCENP BIRC5 AURKC | chromosome localization |
| GO:0051225 | 0.0165038110528 | 1.0 | INCENP BIRC5 AURKC | spindle assembly |
| GO:0051302 | 0.0201788647033 | 1.0 | INCENP BIRC5 AURKC | regulation of cell division |
| GO:0007052 | 0.0225051619375 | 1.0 | INCENP BIRC5 AURKC | mitotic spindle organization |
| CORUM:2580 | 0.0249718442456 | 0.333333333333 | BIRC5 | Survivin homodimer complex |
| REAC:R-HSA-141444 | 0.0284248695791 | 0.666666666667 | INCENP BIRC5 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 0.0284248695791 | 0.666666666667 | INCENP BIRC5 | Amplification of signal from the kinetochores |
| GO:0005875 | 0.0290879429506 | 1.0 | INCENP BIRC5 AURKC | microtubule associated complex |
| GO:1903490 | 0.0294899169624 | 0.666666666667 | INCENP BIRC5 | positive regulation of mitotic cytokinesis |
| REAC:R-HSA-69618 | 0.0392065258044 | 0.666666666667 | INCENP BIRC5 | Mitotic Spindle Checkpoint |
| GO:1902423 | 0.0393180950424 | 0.666666666667 | INCENP BIRC5 | regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:1902425 | 0.0393180950424 | 0.666666666667 | INCENP BIRC5 | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:1902412 | 0.0393180950424 | 0.666666666667 | INCENP BIRC5 | regulation of mitotic cytokinesis |
| GO:0000776 | 0.0402954436201 | 1.0 | INCENP BIRC5 AURKC | kinetochore |
| REAC:R-HSA-9648025 | 0.0429286997388 | 0.666666666667 | INCENP BIRC5 | EML4 and NUDC in mitotic spindle formation |
| GO:1902850 | 0.043021407985 | 1.0 | INCENP BIRC5 AURKC | microtubule cytoskeleton organization involved in mitosis |
| GO:0000779 | 0.0439566559847 | 1.0 | INCENP BIRC5 AURKC | condensed chromosome, centromeric region |
| REAC:R-HSA-2500257 | 0.049233254294 | 0.666666666667 | INCENP BIRC5 | Resolution of Sister Chromatid Cohesion |
| CORUM:2581 | 0.0499402709677 | 0.333333333333 | BIRC5 | RasGAP-AURKA-survivin complex |
| CORUM:1117 | 0.0499402709677 | 0.333333333333 | BIRC5 | CRM1-Survivin mitotic complex |
| CORUM:6756 | 0.0499402709677 | 0.333333333333 | BIRC5 | RasGAP-AURKB-survivin complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| INCENP | AURKC | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BIRC5 | INCENP | 0.994 | 0.758 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes