hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00921.1
Complex Portal: CPX-12946
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DDOST | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit) | 5 | UniProt NCBI |
| RPN1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit) (Ribophorin I) (RPN-I) (Ribophorin-1) | 5 | UniProt NCBI |
| DAD1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (Oligosaccharyl transferase subunit DAD1) (Defender against cell death 1) (DAD-1) | 5 | UniProt NCBI |
| MAGT1 | Magnesium transporter protein 1 (MagT1) (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1) (Oligosaccharyl transferase subunit MAGT1) (Implantation-associated protein) (IAP) | 5 | UniProt NCBI |
| STT3B | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (Oligosaccharyl transferase subunit STT3B) (STT3-B) (EC 2.4.99.18) (Source of immunodominant MHC-associated peptides homolog) | 5 | UniProt NCBI |
| LMF2 | Lipase maturation factor 2 (Transmembrane protein 112B) (Transmembrane protein 153) | 4 | UniProt NCBI |
| CLGN | Calmegin | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1200 | 8.28816370698e-15 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | Oligosaccharyltransferase complex (Stt3B variant) |
| CORUM:1199 | 2.88300486966e-11 | 0.571428571429 | DAD1 MAGT1 DDOST RPN1 | Oligosaccharyltransferase complex (Stt3A variant) |
| GO:0008250 | 8.73008139488e-11 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | oligosaccharyltransferase complex |
| KEGG:00513 | 1.29361057413e-10 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | Various types of N-glycan biosynthesis |
| KEGG:00510 | 3.36322590815e-10 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | N-Glycan biosynthesis |
| GO:0018279 | 4.96990184286e-09 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | protein N-linked glycosylation via asparagine |
| KEGG:04141 | 1.39999416482e-07 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | Protein processing in endoplasmic reticulum |
| REAC:R-HSA-9694548 | 1.85951185977e-07 | 0.571428571429 | DAD1 MAGT1 DDOST RPN1 | Maturation of spike protein |
| WP:WP5153 | 4.13716175819e-07 | 0.571428571429 | DAD1 STT3B DDOST RPN1 | N glycan biosynthesis |
| GO:0006487 | 1.02626003625e-06 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | protein N-linked glycosylation |
| REAC:R-HSA-9694635 | 1.03686148446e-06 | 0.571428571429 | DAD1 MAGT1 DDOST RPN1 | Translation of Structural Proteins |
| REAC:R-HSA-9772573 | 1.97234251471e-06 | 0.571428571429 | DAD1 MAGT1 DDOST RPN1 | Late SARS-CoV-2 Infection Events |
| GO:0140534 | 1.80511788521e-05 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | endoplasmic reticulum protein-containing complex |
| GO:0005789 | 2.89518459743e-05 | 1.0 | DAD1 DDOST CLGN STT3B MAGT1 RPN1 LMF2 | endoplasmic reticulum membrane |
| GO:0098827 | 3.22907078691e-05 | 1.0 | DAD1 DDOST CLGN STT3B MAGT1 RPN1 LMF2 | endoplasmic reticulum subcompartment |
| GO:0042175 | 3.42471669299e-05 | 1.0 | DAD1 DDOST CLGN STT3B MAGT1 RPN1 LMF2 | nuclear outer membrane-endoplasmic reticulum membrane network |
| GO:0006486 | 0.00013411944099 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | protein glycosylation |
| GO:0043413 | 0.00013411944099 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | macromolecule glycosylation |
| GO:0031984 | 0.000222932095867 | 1.0 | DAD1 DDOST CLGN STT3B MAGT1 RPN1 LMF2 | organelle subcompartment |
| GO:0070085 | 0.000239435127266 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | glycosylation |
| REAC:R-HSA-9694516 | 0.000772937908588 | 0.571428571429 | DAD1 MAGT1 DDOST RPN1 | SARS-CoV-2 Infection |
| GO:0009101 | 0.000866307925371 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | glycoprotein biosynthetic process |
| REAC:R-HSA-446203 | 0.000891777587572 | 0.571428571429 | DAD1 MAGT1 DDOST RPN1 | Asparagine N-linked glycosylation |
| CORUM:6131 | 0.000922010129722 | 0.285714285714 | DDOST RPN1 | SELK multiprotein complex |
| HP:0012345 | 0.000977145370486 | 0.428571428571 | MAGT1 DDOST STT3B | Abnormal glycosylation |
| GO:0009100 | 0.00231631929763 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | glycoprotein metabolic process |
| REAC:R-HSA-9679506 | 0.0027504989814 | 0.571428571429 | DAD1 MAGT1 DDOST RPN1 | SARS-CoV Infections |
| GO:0005783 | 0.00333387301604 | 1.0 | DAD1 DDOST CLGN STT3B MAGT1 RPN1 LMF2 | endoplasmic reticulum |
| HP:0032245 | 0.0203347546789 | 0.428571428571 | MAGT1 DDOST STT3B | Abnormal metabolism |
| HP:0003642 | 0.0283864349721 | 0.285714285714 | MAGT1 DDOST | Type I transferrin isoform profile |
| REAC:R-HSA-9824446 | 0.0320441838438 | 0.571428571429 | DAD1 MAGT1 DDOST RPN1 | Viral Infection Pathways |
| GO:1901137 | 0.040815138017 | 0.714285714286 | STT3B DAD1 MAGT1 DDOST RPN1 | carbohydrate derivative biosynthetic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAGT1 | STT3B | 0.999 | 0.826 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| DDOST | STT3B | 0.998 | 0.906 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| DDOST | MAGT1 | 0.997 | 0.596 |
structurally_consistent (Q8TCJ2)
|
bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| DDOST | RPN1 | 0.997 | 0.978 |
structurally_consistent (Q8TCJ2)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| RPN1 | CLGN | 0.996 | 0.074 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| STT3B | CLGN | 0.991 | 0.082 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| RPN1 | STT3B | 0.99 | 0.792 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| MAGT1 | CLGN | 0.99 | 0.054 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| DAD1 | STT3B | 0.977 | 0.83 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| RPN1 | MAGT1 | 0.97 | 0.532 |
structurally_consistent (Q8TCJ2)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| STT3B | LMF2 | 0.961 | 0.194 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DDOST | CLGN | 0.906 | 0.182 | bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| DAD1 | MAGT1 | 0.853 | 0.386 |
structurally_consistent (Q8TCJ2)
|
bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| RPN1 | DAD1 | 0.838 | 0.794 |
structurally_consistent (Q8TCJ2)
|
bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| LMF2 | CLGN | 0.456 | 0.068 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MAGT1 | LMF2 | 0.446 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DAD1 | CLGN | 0.217 | 0.094 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| DDOST | DAD1 | 0.155 | 0.948 | bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only | |
| RPN1 | LMF2 | 0.12 | 0.32 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DDOST | LMF2 | 0.076 | 0.272 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| DAD1 | LMF2 | 0.037 | 0.196 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes