hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00933.1
Complex Portal: CPX-13331
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PEX14 | Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) | 5 | UniProt NCBI |
| NANOS1 | Nanos homolog 1 (NOS-1) (EC_Rep1a) | 5 | UniProt NCBI |
| PHYH | Phytanoyl-CoA dioxygenase, peroxisomal (EC 1.14.11.18) (Phytanic acid oxidase) (Phytanoyl-CoA alpha-hydroxylase) (PhyH) | 5 | UniProt NCBI |
| PEX5 | Peroxisomal targeting signal 1 receptor (PTS1 receptor) (PTS1R) (PTS1-BP) (Peroxin-5) (Peroxisomal C-terminal targeting signal import receptor) (Peroxisome receptor 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0010965 | 1.66514003543e-06 | 0.75 | PHYH PEX14 PEX5 | Abnormal circulating phytanic acid concentration |
| HP:0010571 | 1.66514003543e-06 | 0.75 | PHYH PEX14 PEX5 | Elevated circulating phytanic acid concentration |
| HP:0010964 | 2.56149077436e-06 | 0.75 | PHYH PEX14 PEX5 | Abnormal circulating long-chain fatty-acid concentration |
| KEGG:04146 | 1.42578806455e-05 | 0.75 | PHYH PEX14 PEX5 | Peroxisome |
| HP:0004359 | 8.9495616948e-05 | 0.75 | PHYH PEX14 PEX5 | Abnormal circulating fatty-acid concentration |
| HP:0008064 | 0.00134310215964 | 0.75 | PHYH PEX14 PEX5 | Ichthyosis |
| HP:0001088 | 0.00220521848756 | 0.5 | PEX5 PEX14 | Brushfield spots |
| HP:0002652 | 0.00292857106518 | 0.75 | PHYH PEX14 PEX5 | Skeletal dysplasia |
| HP:0008167 | 0.00350734148159 | 0.5 | PEX5 PEX14 | Very long chain fatty acid accumulation |
| HP:0000662 | 0.00412165152512 | 0.75 | PHYH PEX14 PEX5 | Nyctalopia |
| HP:0000510 | 0.00494096983998 | 0.75 | PHYH PEX14 PEX5 | Rod-cone dystrophy |
| GO:0016560 | 0.00842684400117 | 0.5 | PEX5 PEX14 | protein import into peroxisome matrix, docking |
| HP:0005930 | 0.00929257878792 | 0.75 | PHYH PEX14 PEX5 | Abnormal epiphysis morphology |
| HP:0011040 | 0.0100118295947 | 0.5 | PEX5 PEX14 | Abnormal intrahepatic bile duct morphology |
| REAC:R-HSA-9033241 | 0.0115164156767 | 0.5 | PHYH PEX14 | Peroxisomal protein import |
| HP:0003119 | 0.0126315731793 | 0.75 | PHYH PEX14 PEX5 | Abnormal circulating lipid concentration |
| HP:0007703 | 0.0151385225595 | 0.75 | PHYH PEX14 PEX5 | Abnormality of retinal pigmentation |
| HP:0010655 | 0.0165423111708 | 0.5 | PEX5 PEX14 | Epiphyseal stippling |
| GO:0016561 | 0.0168521501606 | 0.5 | PEX5 PEX14 | protein import into peroxisome matrix, translocation |
| HP:0000556 | 0.019095104138 | 0.75 | PHYH PEX14 PEX5 | Retinal dystrophy |
| HP:0011368 | 0.0241334081412 | 0.75 | PHYH PEX14 PEX5 | Epidermal thickening |
| CORUM:1984 | 0.0249718442456 | 0.25 | PEX14 | PEX14 homodimer complex |
| GO:0044721 | 0.0280843539964 | 0.5 | PEX5 PEX14 | protein import into peroxisome matrix, substrate release |
| HP:0008207 | 0.034474601612 | 0.5 | PEX5 PEX14 | Primary adrenal insufficiency |
| HP:0001072 | 0.0346490682778 | 0.75 | PHYH PEX14 PEX5 | Thickened skin |
| HP:0009891 | 0.036003514982 | 0.5 | PEX5 PEX14 | Underdeveloped supraorbital ridges |
| HP:0002376 | 0.0367022439828 | 0.75 | PHYH PEX14 PEX5 | Developmental regression |
| HP:0000474 | 0.0391604009626 | 0.5 | PEX5 PEX14 | Thickened nuchal skin fold |
| HP:0005469 | 0.040788355352 | 0.5 | PEX5 PEX14 | Flat occiput |
| HP:0000627 | 0.0458701548093 | 0.5 | PEX5 PEX14 | Posterior embryotoxon |
| HP:0008048 | 0.0458701548093 | 0.5 | PEX5 PEX14 | Abnormal line of Schwalbe morphology |
| HP:0007598 | 0.049422876951 | 0.5 | PEX5 PEX14 | Bilateral single transverse palmar creases |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PHYH | PEX5 | 0.967 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| PEX14 | PHYH | 0.961 | 0.082 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| NANOS1 | PHYH | 0.953 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PEX14 | PEX5 | 0.871 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| PEX14 | NANOS1 | 0.022 |
mutually_exclusive (O14832)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes