hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00934.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SLC35B3 | Adenosine 3'-phospho 5'-phosphosulfate transporter 2 (3'-phosphoadenosine 5'-phosphosulfate transporter) (PAPS transporter 2) (Solute carrier family 35 member B3) | 5 | UniProt NCBI |
| GTPBP6 | Putative GTP-binding protein 6 (Pseudoautosomal GTP-binding protein-like) | 3 | UniProt NCBI |
| TRMT10C | tRNA methyltransferase 10 homolog C (HBV pre-S2 trans-regulated protein 2) (Mitochondrial ribonuclease P protein 1) (Mitochondrial RNase P protein 1) (RNA (guanine-9-)-methyltransferase domain-containing protein 1) (Renal carcinoma antigen NY-REN-49) (mRNA methyladenosine-N(1)-methyltransferase) (EC 2.1.1.-) (tRNA (adenine(9)-N(1))-methyltransferase) (EC 2.1.1.218) (tRNA (guanine(9)-N(1))-methyltransferase) (EC 2.1.1.221) | 5 | UniProt NCBI |
| DECR1 | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (EC 1.3.1.124) (2,4-dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]) (Short chain dehydrogenase/reductase family 18C member 1) | 5 | UniProt NCBI |
| ELAC2 | Zinc phosphodiesterase ELAC protein 2 (EC 3.1.26.11) (ElaC homolog protein 2) (Heredity prostate cancer protein 2) (Ribonuclease Z 2) (RNase Z 2) (tRNA 3 endonuclease 2) (tRNase Z 2) | 5 | UniProt NCBI |
| HSD17B10 | 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6785470 | 3.12013984232e-08 | 0.6 | HSD17B10 TRMT10C ELAC2 | tRNA processing in the mitochondrion |
| REAC:R-HSA-8868766 | 3.74224604281e-07 | 0.6 | HSD17B10 TRMT10C ELAC2 | rRNA processing in the mitochondrion |
| GO:1990180 | 3.84440695359e-06 | 0.6 | HSD17B10 TRMT10C ELAC2 | mitochondrial tRNA 3'-end processing |
| CORUM:7429 | 1.36501667663e-05 | 0.4 | TRMT10C HSD17B10 | HSD17B10-TRMT10C complex |
| GO:0000965 | 1.92180881975e-05 | 0.6 | HSD17B10 TRMT10C ELAC2 | mitochondrial RNA 3'-end processing |
| GO:0042780 | 1.92180881975e-05 | 0.6 | HSD17B10 TRMT10C ELAC2 | tRNA 3'-end processing |
| CORUM:7428 | 4.09448956317e-05 | 0.4 | TRMT10C HSD17B10 | mtRNase P |
| WP:WP5241 | 0.000211546265436 | 0.4 | DECR1 HSD17B10 | Mitochondrial beta oxidation |
| GO:0090646 | 0.000274621184043 | 0.6 | HSD17B10 TRMT10C ELAC2 | mitochondrial tRNA processing |
| REAC:R-HSA-6787450 | 0.000425287580531 | 0.4 | TRMT10C HSD17B10 | tRNA modification in the mitochondrion |
| REAC:R-HSA-72306 | 0.000484679960429 | 0.6 | HSD17B10 TRMT10C ELAC2 | tRNA processing |
| GO:0000963 | 0.00109385703544 | 0.6 | HSD17B10 TRMT10C ELAC2 | mitochondrial RNA processing |
| REAC:R-HSA-72312 | 0.0040163868282 | 0.6 | HSD17B10 TRMT10C ELAC2 | rRNA processing |
| GO:0009295 | 0.0102064666638 | 0.6 | HSD17B10 TRMT10C ELAC2 | nucleoid |
| GO:0042645 | 0.0102064666638 | 0.6 | HSD17B10 TRMT10C ELAC2 | mitochondrial nucleoid |
| HP:0003128 | 0.0117509702765 | 0.6 | HSD17B10 TRMT10C ELAC2 | Lactic acidosis |
| GO:0000959 | 0.0126766174236 | 0.6 | HSD17B10 TRMT10C ELAC2 | mitochondrial RNA metabolic process |
| GO:0030678 | 0.0140440992017 | 0.4 | TRMT10C HSD17B10 | mitochondrial ribonuclease P complex |
| GO:0097745 | 0.0140440992017 | 0.4 | TRMT10C HSD17B10 | mitochondrial tRNA 5'-end processing |
| GO:0070901 | 0.0280843539964 | 0.4 | TRMT10C HSD17B10 | mitochondrial tRNA methylation |
| GO:0000964 | 0.0280843539964 | 0.4 | TRMT10C HSD17B10 | mitochondrial RNA 5'-end processing |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TRMT10C | ELAC2 | 0.999 | 0.16 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TRMT10C | HSD17B10 | 0.998 | 0.182 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM treiber_WMM |
| GTPBP6 | ELAC2 | 0.991 | 0.086 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GTPBP6 | TRMT10C | 0.973 | 0.248 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
| DECR1 | ELAC2 | 0.971 | 0.138 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| TRMT10C | DECR1 | 0.962 | 0.106 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| SLC35B3 | TRMT10C | 0.958 | 0.14 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ELAC2 | HSD17B10 | 0.957 | 0.078 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| GTPBP6 | DECR1 | 0.945 | 0.078 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| GTPBP6 | HSD17B10 | 0.941 | 0.196 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only treiber_WMM |
| DECR1 | HSD17B10 | 0.884 | 0.352 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 treiber_WMM WMM_only |
| SLC35B3 | HSD17B10 | 0.001 | 0.098 | bioplex3_HEK293 bioplex () bioplex3_HCT116 gupta_WMM |
Related Complexes