hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00936.1
Complex Portal: CPX-19377
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| THOC6 | THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58) | 5 | UniProt NCBI |
| THOC3 | THO complex subunit 3 (Tho3) (TEX1 homolog) (hTREX45) | 5 | UniProt NCBI |
| RSPO1 | R-spondin-1 (Roof plate-specific spondin-1) (hRspo1) | 5 | UniProt NCBI |
| ALYREF | THO complex subunit 4 (Tho4) (Ally of AML-1 and LEF-1) (Aly/REF export factor) (Transcriptional coactivator Aly/REF) (bZIP-enhancing factor BEF) | 5 | UniProt NCBI |
| CHTOP | Chromatin target of PRMT1 protein (Friend of PRMT1 protein) (Small arginine- and glycine-rich protein) (SRAG) | 5 | UniProt NCBI |
| PRMT1 | Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-72187 | 8.14372399533e-05 | 0.6 | THOC6 CHTOP THOC3 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 0.000123167229073 | 0.6 | THOC6 CHTOP THOC3 | RNA Polymerase II Transcription Termination |
| CORUM:6858 | 0.000136445626745 | 0.4 | PRMT1 CHTOP | CHTOP-methylosome complex |
| GO:0000346 | 0.000158467845213 | 0.6 | THOC6 CHTOP THOC3 | transcription export complex |
| REAC:R-HSA-159236 | 0.000169658686915 | 0.6 | THOC6 CHTOP THOC3 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| CORUM:6160 | 0.000204640425412 | 0.4 | THOC6 THOC3 | hTREX84 complex |
| REAC:R-HSA-72202 | 0.000244866764891 | 0.6 | THOC6 CHTOP THOC3 | Transport of Mature Transcript to Cytoplasm |
| CORUM:770 | 0.000286457379015 | 0.4 | THOC6 THOC3 | TREX complex |
| REAC:R-HSA-72203 | 0.0102904130445 | 0.6 | THOC6 CHTOP THOC3 | Processing of Capped Intron-Containing Pre-mRNA |
| KEGG:03013 | 0.0226459969921 | 0.4 | THOC6 THOC3 | Nucleocytoplasmic transport |
| REAC:R-HSA-73857 | 0.0284318585439 | 0.8 | THOC6 PRMT1 CHTOP THOC3 | RNA Polymerase II Transcription |
| GO:0006406 | 0.0437005530348 | 0.6 | THOC6 CHTOP THOC3 | mRNA export from nucleus |
| REAC:R-HSA-74160 | 0.046583533294 | 0.8 | THOC6 PRMT1 CHTOP THOC3 | Gene expression (Transcription) |
| CORUM:1731 | 0.0498708842806 | 0.2 | PRMT1 | PRMT1 complex |
| CORUM:2765 | 0.0498708842806 | 0.2 | PRMT1 | PRMT1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| THOC6 | THOC3 | 1.0 | 0.342 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| ALYREF | CHTOP | 0.999 | 0.572 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| PRMT1 | CHTOP | 0.995 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only | ||
| RSPO1 | CHTOP | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| THOC3 | ALYREF | 0.984 | 0.246 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| THOC6 | CHTOP | 0.972 | 0.146 |
mutually_exclusive (Q96J01)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM fraction |
| THOC3 | CHTOP | 0.97 | 0.134 |
mutually_exclusive (Q96A72)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| PRMT1 | ALYREF | 0.965 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | ||
| THOC6 | ALYREF | 0.949 | 0.284 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| PRMT1 | THOC6 | 0.845 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PRMT1 | THOC3 | 0.122 | hein_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM WMM_only | ||
| THOC6 | RSPO1 | 0.038 | bioplex3_HEK293 bioplex () bioplex3_WMM | ||
| THOC3 | RSPO1 | 0.009 | bioplex3_HEK293 bioplex () | ||
| RSPO1 | ALYREF | 0.004 | bioplex3_HEK293 bioplex () bioplex3_HCT116 | ||
| PRMT1 | RSPO1 | 0.001 | bioplex3_HEK293 bioplex () bioplex3_HCT116 |
Related Complexes