hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_00946.1

Complex Portal: CPX-20753

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
INCENP	Inner centromere protein	5	UniProt NCBI
AURKC	Aurora kinase C (EC 2.7.11.1) (Aurora 3) (Aurora/IPL1-related kinase 3) (ARK-3) (Aurora-related kinase 3) (Aurora/IPL1/Eg2 protein 2) (Serine/threonine-protein kinase 13) (Serine/threonine-protein kinase aurora-C)	5	UniProt NCBI
BIRC5	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)	5	UniProt NCBI
CDCA8	Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0032133	3.94689465137e-10	1.0	BIRC5 INCENP CDCA8 AURKC	chromosome passenger complex
CORUM:1120	7.01606139244e-10	0.75	INCENP CDCA8 BIRC5	Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5)
CORUM:1119	2.80628050973e-09	0.75	INCENP CDCA8 BIRC5	Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB)
CORUM:1118	2.80628050973e-09	0.75	INCENP CDCA8 BIRC5	Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB)
GO:0051256	8.68316823302e-09	1.0	BIRC5 INCENP CDCA8 AURKC	mitotic spindle midzone assembly
GO:0051255	1.30247523495e-08	1.0	BIRC5 INCENP CDCA8 AURKC	spindle midzone assembly
GO:0000022	1.30247523495e-08	1.0	BIRC5 INCENP CDCA8 AURKC	mitotic spindle elongation
GO:0051231	1.88135311715e-08	1.0	BIRC5 INCENP CDCA8 AURKC	spindle elongation
GO:0032467	1.22027457568e-06	1.0	BIRC5 INCENP CDCA8 AURKC	positive regulation of cytokinesis
GO:0051781	2.40471134793e-06	1.0	BIRC5 INCENP CDCA8 AURKC	positive regulation of cell division
GO:0008608	6.05979892141e-06	1.0	BIRC5 INCENP CDCA8 AURKC	attachment of spindle microtubules to kinetochore
GO:1903490	1.34540429244e-05	0.75	INCENP CDCA8 BIRC5	positive regulation of mitotic cytokinesis
GO:0090307	1.37313780553e-05	1.0	BIRC5 INCENP CDCA8 AURKC	mitotic spindle assembly
CORUM:2579	1.53774525569e-05	0.5	INCENP BIRC5	Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB)
CORUM:2582	1.53774525569e-05	0.5	BIRC5 CDCA8	Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5)
REAC:R-HSA-4615885	1.60766305396e-05	0.75	INCENP CDCA8 BIRC5	SUMOylation of DNA replication proteins
GO:1902425	2.15253635486e-05	0.75	INCENP CDCA8 BIRC5	positive regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1902423	2.15253635486e-05	0.75	INCENP CDCA8 BIRC5	regulation of attachment of mitotic spindle microtubules to kinetochore
GO:1902412	2.15253635486e-05	0.75	INCENP CDCA8 BIRC5	regulation of mitotic cytokinesis
GO:0032465	2.86394569693e-05	1.0	BIRC5 INCENP CDCA8 AURKC	regulation of cytokinesis
CORUM:1087	3.07520988333e-05	0.5	INCENP BIRC5	BIRC5-AURKB-INCENP-EVI5 complex
GO:0051987	6.34131776058e-05	0.75	INCENP CDCA8 BIRC5	positive regulation of attachment of spindle microtubules to kinetochore
GO:0051310	7.03249795192e-05	1.0	BIRC5 INCENP CDCA8 AURKC	metaphase chromosome alignment
GO:0051303	8.0240394575e-05	1.0	BIRC5 INCENP CDCA8 AURKC	establishment of chromosome localization
GO:0090235	8.45465618902e-05	0.75	INCENP CDCA8 BIRC5	regulation of metaphase plate congression
GO:0090267	8.45465618902e-05	0.75	INCENP CDCA8 BIRC5	positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:0050000	9.90506366677e-05	1.0	BIRC5 INCENP CDCA8 AURKC	chromosome localization
GO:0090232	0.000109904886398	0.75	INCENP CDCA8 BIRC5	positive regulation of spindle checkpoint
GO:0051225	0.000111817498921	1.0	BIRC5 INCENP CDCA8 AURKC	spindle assembly
GO:0051302	0.000146383770774	1.0	BIRC5 INCENP CDCA8 AURKC	regulation of cell division
GO:0007052	0.000169420189784	1.0	BIRC5 INCENP CDCA8 AURKC	mitotic spindle organization
REAC:R-HSA-141424	0.000175410417245	0.75	INCENP CDCA8 BIRC5	Amplification of signal from the kinetochores
REAC:R-HSA-141444	0.000175410417245	0.75	INCENP CDCA8 BIRC5	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
GO:0005875	0.000238882641259	1.0	BIRC5 INCENP CDCA8 AURKC	microtubule associated complex
REAC:R-HSA-69618	0.000284930280132	0.75	INCENP CDCA8 BIRC5	Mitotic Spindle Checkpoint
GO:1901970	0.000313494264121	0.75	INCENP CDCA8 BIRC5	positive regulation of mitotic sister chromatid separation
GO:1901978	0.000313494264121	0.75	INCENP CDCA8 BIRC5	positive regulation of cell cycle checkpoint
REAC:R-HSA-9648025	0.000326687544455	0.75	INCENP CDCA8 BIRC5	EML4 and NUDC in mitotic spindle formation
GO:0090266	0.000372255315939	0.75	INCENP CDCA8 BIRC5	regulation of mitotic cell cycle spindle assembly checkpoint
GO:1903504	0.000372255315939	0.75	INCENP CDCA8 BIRC5	regulation of mitotic spindle checkpoint
REAC:R-HSA-2500257	0.000401649591062	0.75	INCENP CDCA8 BIRC5	Resolution of Sister Chromatid Cohesion
GO:1902850	0.000403362503007	1.0	BIRC5 INCENP CDCA8 AURKC	microtubule cytoskeleton organization involved in mitosis
GO:0051988	0.000437924933217	0.75	INCENP CDCA8 BIRC5	regulation of attachment of spindle microtubules to kinetochore
GO:0090231	0.000437924933217	0.75	INCENP CDCA8 BIRC5	regulation of spindle checkpoint
REAC:R-HSA-5663220	0.000522246528354	0.75	INCENP CDCA8 BIRC5	RHO GTPases Activate Formins
GO:0030496	0.000533101140219	1.0	BIRC5 INCENP CDCA8 AURKC	midbody
GO:0000910	0.000657606458249	1.0	BIRC5 INCENP CDCA8 AURKC	cytokinesis
GO:0000070	0.000709501150068	1.0	BIRC5 INCENP CDCA8 AURKC	mitotic sister chromatid segregation
GO:0007051	0.0007274632045	1.0	BIRC5 INCENP CDCA8 AURKC	spindle organization
GO:0051315	0.000777349058504	0.75	INCENP CDCA8 BIRC5	attachment of mitotic spindle microtubules to kinetochore
REAC:R-HSA-3108232	0.000897810107574	0.75	INCENP CDCA8 BIRC5	SUMO E3 ligases SUMOylate target proteins
REAC:R-HSA-2990846	0.000986096194174	0.75	INCENP CDCA8 BIRC5	SUMOylation
GO:1905820	0.00125794076491	0.75	INCENP CDCA8 BIRC5	positive regulation of chromosome separation
GO:0051984	0.00125794076491	0.75	INCENP CDCA8 BIRC5	positive regulation of chromosome segregation
GO:0090068	0.00127030093913	1.0	BIRC5 INCENP CDCA8 AURKC	positive regulation of cell cycle process
REAC:R-HSA-2467813	0.00141990352599	0.75	INCENP CDCA8 BIRC5	Separation of Sister Chromatids
GO:0000775	0.00156892706691	1.0	BIRC5 INCENP CDCA8 AURKC	chromosome, centromeric region
REAC:R-HSA-68877	0.0016906924478	0.75	INCENP CDCA8 BIRC5	Mitotic Prometaphase
GO:0000819	0.0017020312212	1.0	BIRC5 INCENP CDCA8 AURKC	sister chromatid segregation
GO:0051233	0.00229706847948	0.75	INCENP CDCA8 AURKC	spindle midzone
REAC:R-HSA-68882	0.00252982363853	0.75	INCENP CDCA8 BIRC5	Mitotic Anaphase
REAC:R-HSA-2555396	0.00256403202009	0.75	INCENP CDCA8 BIRC5	Mitotic Metaphase and Anaphase
GO:0140014	0.00278481835296	1.0	BIRC5 INCENP CDCA8 AURKC	mitotic nuclear division
GO:0051301	0.0033151614032	1.0	BIRC5 INCENP CDCA8 AURKC	cell division
GO:0098813	0.00366770658506	1.0	BIRC5 INCENP CDCA8 AURKC	nuclear chromosome segregation
GO:0045787	0.00372909079569	1.0	BIRC5 INCENP CDCA8 AURKC	positive regulation of cell cycle
GO:0071174	0.00409056451107	0.75	INCENP CDCA8 BIRC5	mitotic spindle checkpoint signaling
GO:1901976	0.00409056451107	0.75	INCENP CDCA8 BIRC5	regulation of cell cycle checkpoint
GO:0071173	0.00409056451107	0.75	INCENP CDCA8 BIRC5	spindle assembly checkpoint signaling
GO:0007094	0.00409056451107	0.75	INCENP CDCA8 BIRC5	mitotic spindle assembly checkpoint signaling
GO:0033048	0.00440499676786	0.75	INCENP CDCA8 BIRC5	negative regulation of mitotic sister chromatid segregation
GO:0045841	0.00440499676786	0.75	INCENP CDCA8 BIRC5	negative regulation of mitotic metaphase/anaphase transition
GO:0033046	0.00440499676786	0.75	INCENP CDCA8 BIRC5	negative regulation of sister chromatid segregation
GO:0031577	0.00440499676786	0.75	INCENP CDCA8 BIRC5	spindle checkpoint signaling
GO:2000816	0.00440499676786	0.75	INCENP CDCA8 BIRC5	negative regulation of mitotic sister chromatid separation
REAC:R-HSA-69620	0.00495341247057	0.75	INCENP CDCA8 BIRC5	Cell Cycle Checkpoints
GO:1902100	0.00508133939815	0.75	INCENP CDCA8 BIRC5	negative regulation of metaphase/anaphase transition of cell cycle
GO:1905819	0.00508133939815	0.75	INCENP CDCA8 BIRC5	negative regulation of chromosome separation
GO:0051985	0.00508133939815	0.75	INCENP CDCA8 BIRC5	negative regulation of chromosome segregation
REAC:R-HSA-195258	0.00591360366085	0.75	INCENP CDCA8 BIRC5	RHO GTPase Effectors
GO:0033047	0.00663460918661	0.75	INCENP CDCA8 BIRC5	regulation of mitotic sister chromatid segregation
GO:0045839	0.00706693750215	0.75	INCENP CDCA8 BIRC5	negative regulation of mitotic nuclear division
GO:0010965	0.00847564117007	0.75	INCENP CDCA8 BIRC5	regulation of mitotic sister chromatid separation
GO:0051784	0.00847564117007	0.75	INCENP CDCA8 BIRC5	negative regulation of nuclear division
GO:0051306	0.00951168180783	0.75	INCENP CDCA8 BIRC5	mitotic sister chromatid separation
GO:0140694	0.00993029840085	1.0	BIRC5 INCENP CDCA8 AURKC	non-membrane-bounded organelle assembly
GO:0000280	0.0105899075134	1.0	BIRC5 INCENP CDCA8 AURKC	nuclear division
GO:0098687	0.0111408206209	1.0	BIRC5 INCENP CDCA8 AURKC	chromosomal region
GO:0007080	0.0112187083505	0.75	INCENP CDCA8 BIRC5	mitotic metaphase chromosome alignment
GO:0007059	0.0117129540232	1.0	BIRC5 INCENP CDCA8 AURKC	chromosome segregation
REAC:R-HSA-68886	0.0131851712206	0.75	INCENP CDCA8 BIRC5	M Phase
GO:0048285	0.0169270306723	1.0	BIRC5 INCENP CDCA8 AURKC	organelle fission
GO:1905818	0.0175369202004	0.75	INCENP CDCA8 BIRC5	regulation of chromosome separation
GO:0051656	0.0195656568104	1.0	BIRC5 INCENP CDCA8 AURKC	establishment of organelle localization
GO:0051304	0.0228491864842	0.75	INCENP CDCA8 BIRC5	chromosome separation
CORUM:2580	0.0249718442456	0.25	BIRC5	Survivin homodimer complex
GO:0000281	0.0314640437065	0.75	INCENP CDCA8 BIRC5	mitotic cytokinesis
REAC:R-HSA-69278	0.0329329593357	0.75	INCENP CDCA8 BIRC5	Cell Cycle, Mitotic
GO:0030071	0.0339114962397	0.75	INCENP CDCA8 BIRC5	regulation of mitotic metaphase/anaphase transition
GO:1902099	0.0364824972322	0.75	INCENP CDCA8 BIRC5	regulation of metaphase/anaphase transition of cell cycle
GO:0007091	0.0391800710576	0.75	INCENP CDCA8 BIRC5	metaphase/anaphase transition of mitotic cell cycle
GO:2001251	0.0405772675542	0.75	INCENP CDCA8 BIRC5	negative regulation of chromosome organization
GO:0044784	0.0420072408269	0.75	INCENP CDCA8 BIRC5	metaphase/anaphase transition of cell cycle
CORUM:2581	0.049938562206	0.25	BIRC5	RasGAP-AURKA-survivin complex
CORUM:1117	0.049938562206	0.25	BIRC5	CRM1-Survivin mitotic complex
CORUM:6756	0.049938562206	0.25	BIRC5	RasGAP-AURKB-survivin complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
INCENP	AURKC	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
BIRC5	CDCA8	0.999	0.59	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CDCA8	INCENP	0.998	0.606	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
BIRC5	INCENP	0.994	0.758	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM

Related Complexes

Genename	Complexes
INCENP	huMAP3_00910.1 huMAP3_00946.1 huMAP3_03562.1 huMAP3_04305.1 huMAP3_04346.1 huMAP3_08157.1 huMAP3_09538.1 huMAP3_11479.1 huMAP3_12277.1
AURKC	huMAP3_00910.1 huMAP3_00946.1 huMAP3_03562.1 huMAP3_04596.1 huMAP3_09284.1 huMAP3_09538.1 huMAP3_10471.1 huMAP3_11479.1 huMAP3_12277.1
BIRC5	huMAP3_00111.1 huMAP3_00910.1 huMAP3_00946.1 huMAP3_01130.1 huMAP3_04346.1 huMAP3_08157.1 huMAP3_08415.1 huMAP3_11479.1 huMAP3_12277.1 huMAP3_12835.1 huMAP3_14108.1 huMAP3_14708.1
CDCA8	huMAP3_00111.1 huMAP3_00946.1 huMAP3_04305.1 huMAP3_04346.1 huMAP3_07363.1 huMAP3_07686.1 huMAP3_09538.1 huMAP3_11479.1 huMAP3_12277.1 huMAP3_12835.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_00946.1

Complex Portal: CPX-20753