hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00960.1
Complex Portal: CPX-24717
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DDX23 | Probable ATP-dependent RNA helicase DDX23 (EC 3.6.4.13) (100 kDa U5 snRNP-specific protein) (DEAD box protein 23) (PRP28 homolog) (U5-100kD) | 5 | UniProt NCBI |
| PRPF6 | Pre-mRNA-processing factor 6 (Androgen receptor N-terminal domain-transactivating protein 1) (ANT-1) (PRP6 homolog) (U5 snRNP-associated 102 kDa protein) (U5-102 kDa protein) | 5 | UniProt NCBI |
| EFTUD2 | 116 kDa U5 small nuclear ribonucleoprotein component (Elongation factor Tu GTP-binding domain-containing protein 2) (SNU114 homolog) (hSNU114) (U5 snRNP-specific protein, 116 kDa) (U5-116 kDa) | 5 | UniProt NCBI |
| PRPF8 | Pre-mRNA-processing-splicing factor 8 (220 kDa U5 snRNP-specific protein) (PRP8 homolog) (Splicing factor Prp8) (p220) | 5 | UniProt NCBI |
| SNRNP40 | U5 small nuclear ribonucleoprotein 40 kDa protein (U5 snRNP 40 kDa protein) (U5-40K) (38 kDa-splicing factor) (Prp8-binding protein) (hPRP8BP) (U5 snRNP-specific 40 kDa protein) (WD repeat-containing protein 57) | 5 | UniProt NCBI |
| ZNHIT2 | Zinc finger HIT domain-containing protein 2 (Protein FON) | 4 | UniProt NCBI |
| PAXBP1 | PAX3- and PAX7-binding protein 1 (GC-rich sequence DNA-binding factor 1) | 5 | UniProt NCBI |
| SNRNP200 | U5 small nuclear ribonucleoprotein 200 kDa helicase (EC 3.6.4.13) (Activating signal cointegrator 1 complex subunit 3-like 1) (BRR2 homolog) (U5 snRNP-specific 200 kDa protein) (U5-200KD) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:351 | 3.94740525029e-12 | 0.875 | SNRNP200 DDX23 PAXBP1 PRPF8 SNRNP40 PRPF6 EFTUD2 | Spliceosome |
| REAC:R-HSA-72165 | 5.38022652973e-12 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | mRNA Splicing - Minor Pathway |
| CORUM:1181 | 4.44249750468e-11 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | C complex spliceosome |
| GO:0046540 | 1.38795875476e-10 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 1.38795875476e-10 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | spliceosomal tri-snRNP complex |
| KEGG:03040 | 4.74173522744e-10 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | Spliceosome |
| GO:0005682 | 4.31077484224e-09 | 0.625 | PRPF6 SNRNP40 DDX23 SNRNP200 PRPF8 | U5 snRNP |
| CORUM:1335 | 4.57686144475e-09 | 0.5 | PRPF8 DDX23 SNRNP200 EFTUD2 | SNW1 complex |
| GO:0097525 | 7.71019557823e-09 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | spliceosomal snRNP complex |
| GO:0030532 | 1.74875717043e-08 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | small nuclear ribonucleoprotein complex |
| REAC:R-HSA-72163 | 3.65751138034e-08 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | mRNA Splicing - Major Pathway |
| GO:0120114 | 4.48653214139e-08 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | Sm-like protein family complex |
| REAC:R-HSA-72172 | 4.49924017189e-08 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | mRNA Splicing |
| GO:0071013 | 5.17906168383e-08 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | catalytic step 2 spliceosome |
| REAC:R-HSA-72203 | 2.37419309691e-07 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0005681 | 3.11412952668e-06 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | spliceosomal complex |
| GO:0005684 | 2.06306777598e-05 | 0.625 | PRPF6 SNRNP40 EFTUD2 SNRNP200 PRPF8 | U2-type spliceosomal complex |
| WP:WP411 | 2.87665270267e-05 | 0.5 | PRPF6 SNRNP40 EFTUD2 PRPF8 | mRNA processing |
| GO:0000377 | 4.66723234343e-05 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 4.66723234343e-05 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | mRNA splicing, via spliceosome |
| GO:0000375 | 5.10637938691e-05 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | RNA splicing, via transesterification reactions |
| REAC:R-HSA-8953854 | 5.65270307937e-05 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | Metabolism of RNA |
| GO:0006397 | 0.000186882644833 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | mRNA processing |
| GO:0008380 | 0.000317862592208 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | RNA splicing |
| GO:0071005 | 0.000419928845551 | 0.5 | PRPF6 EFTUD2 SNRNP200 PRPF8 | U2-type precatalytic spliceosome |
| GO:0071011 | 0.000493423074079 | 0.5 | PRPF6 EFTUD2 SNRNP200 PRPF8 | precatalytic spliceosome |
| GO:0016071 | 0.00379022160939 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | mRNA metabolic process |
| HP:0007675 | 0.00543763778541 | 0.375 | PRPF6 SNRNP200 PRPF8 | Progressive night blindness |
| GO:1990904 | 0.00562722320932 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | ribonucleoprotein complex |
| HP:0030786 | 0.00640296160267 | 0.375 | PRPF6 SNRNP200 PRPF8 | Photopsia |
| HP:0007994 | 0.0066608265632 | 0.375 | PRPF6 SNRNP200 PRPF8 | Peripheral visual field loss |
| HP:0007787 | 0.00805364445667 | 0.375 | PRPF6 SNRNP200 PRPF8 | Posterior subcapsular cataract |
| HP:0007737 | 0.00962678270997 | 0.375 | PRPF6 SNRNP200 PRPF8 | Bone spicule pigmentation of the retina |
| HP:0000563 | 0.00996398562078 | 0.375 | PRPF6 SNRNP200 PRPF8 | Keratoconus |
| HPA:0610833 | 0.0102260681367 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | urinary bladder; urothelial cells[High] |
| HP:0000405 | 0.0102355925102 | 0.5 | PRPF6 EFTUD2 SNRNP200 PRPF8 | Conductive hearing impairment |
| HP:0000523 | 0.0106616456577 | 0.375 | PRPF6 SNRNP200 PRPF8 | Subcapsular cataract |
| HP:0011452 | 0.0109195176361 | 0.5 | PRPF6 EFTUD2 SNRNP200 PRPF8 | Functional abnormality of the middle ear |
| HP:0100692 | 0.0110222721137 | 0.375 | PRPF6 SNRNP200 PRPF8 | Increased corneal curvature |
| HP:0100689 | 0.0113908755966 | 0.375 | PRPF6 SNRNP200 PRPF8 | Decreased corneal thickness |
| GO:0000354 | 0.0131096201623 | 0.25 | SNRNP200 DDX23 | cis assembly of pre-catalytic spliceosome |
| HP:0011486 | 0.013356500578 | 0.375 | PRPF6 SNRNP200 PRPF8 | Abnormality of corneal thickness |
| HP:0007843 | 0.0155341784615 | 0.375 | PRPF6 SNRNP200 PRPF8 | Attenuation of retinal blood vessels |
| HPA:0010012 | 0.016644306355 | 0.75 | DDX23 PAXBP1 PRPF8 SNRNP40 PRPF6 EFTUD2 | adipose tissue; adipocytes[>=Medium] |
| HP:0001133 | 0.0200217380769 | 0.375 | PRPF6 SNRNP200 PRPF8 | Constriction of peripheral visual field |
| HPA:0170053 | 0.0213175771054 | 0.625 | PRPF8 PRPF6 SNRNP40 DDX23 EFTUD2 | endometrium 2; glandular cells[High] |
| GO:0071007 | 0.0217028525661 | 0.375 | PRPF8 EFTUD2 SNRNP40 | U2-type catalytic step 2 spliceosome |
| HP:0000842 | 0.0228486544917 | 0.375 | PRPF6 SNRNP200 PRPF8 | Hyperinsulinemia |
| GO:0006396 | 0.0262049478083 | 0.75 | SNRNP200 DDX23 PRPF8 SNRNP40 PRPF6 EFTUD2 | RNA processing |
| HP:0040214 | 0.0265738611142 | 0.375 | PRPF6 SNRNP200 PRPF8 | Abnormal circulating insulin concentration |
| HPA:0010011 | 0.0368302147851 | 0.875 | SNRNP200 DDX23 PAXBP1 PRPF8 SNRNP40 PRPF6 EFTUD2 | adipose tissue; adipocytes[>=Low] |
| HPA:0010000 | 0.0368302147851 | 0.875 | SNRNP200 DDX23 PAXBP1 PRPF8 SNRNP40 PRPF6 EFTUD2 | adipose tissue |
| GO:0030623 | 0.0393180950424 | 0.25 | PRPF8 EFTUD2 | U5 snRNA binding |
| HPA:0620222 | 0.0434766817865 | 0.875 | SNRNP200 DDX23 PAXBP1 PRPF8 SNRNP40 PRPF6 EFTUD2 | vagina; squamous epithelial cells[>=Medium] |
| HPA:0600432 | 0.0465230549318 | 0.875 | SNRNP200 DDX23 PAXBP1 PRPF8 SNRNP40 PRPF6 EFTUD2 | tonsil; germinal center cells[>=Medium] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EFTUD2 | PRPF8 | 1.0 | 0.996 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| EFTUD2 | SNRNP200 | 1.0 | 0.992 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| PRPF8 | SNRNP200 | 1.0 | 0.994 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| SNRNP40 | DDX23 | 1.0 | 0.798 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| EFTUD2 | SNRNP40 | 0.999 | 0.788 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| DDX23 | PRPF6 | 0.999 | 0.944 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| EFTUD2 | DDX23 | 0.999 | 0.922 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| SNRNP40 | SNRNP200 | 0.999 | 0.94 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| SNRNP40 | PRPF8 | 0.999 | 0.968 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| EFTUD2 | PRPF6 | 0.999 | 0.908 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| SNRNP40 | PAXBP1 | 0.999 | 0.334 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| SNRNP40 | PRPF6 | 0.998 | 0.81 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| PRPF6 | SNRNP200 | 0.997 | 0.932 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| DDX23 | PRPF8 | 0.997 | 0.95 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| SNRNP40 | ZNHIT2 | 0.996 | 0.134 |
structurally_consistent (Q15029)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| DDX23 | SNRNP200 | 0.996 | 0.944 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| PRPF6 | PRPF8 | 0.995 | 0.94 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| EFTUD2 | ZNHIT2 | 0.991 | 0.184 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PRPF6 | PAXBP1 | 0.991 | 0.414 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only treiber_WMM | |
| DDX23 | PAXBP1 | 0.961 | 0.512 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM | |
| EFTUD2 | PAXBP1 | 0.959 | 0.408 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM treiber_WMM WMM_only |
| PAXBP1 | SNRNP200 | 0.953 | 0.668 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only treiber_WMM | |
| ZNHIT2 | SNRNP200 | 0.95 | 0.252 | bioplex_WMM bioplex3_WMM WMM_only | |
| PRPF8 | PAXBP1 | 0.92 | 0.506 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM | |
| PRPF6 | ZNHIT2 | 0.835 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only | |
| DDX23 | ZNHIT2 | 0.812 | 0.212 | bioplex_WMM bioplex3_WMM WMM_only | |
| PRPF8 | ZNHIT2 | 0.808 | 0.102 | bioplex_WMM bioplex3_WMM WMM_only | |
| ZNHIT2 | PAXBP1 | 0.202 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes