hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_00975.1
Complex Portal: CPX-11014
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4A1 | Eukaryotic initiation factor 4A-I (eIF-4A-I) (eIF4A-I) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-1) | 5 | UniProt NCBI |
| EIF4A2 | Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2) | 5 | UniProt NCBI |
| EIF4G1 | Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G 1) (eIF-4G1) (p220) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4566 | 8.26322288609e-07 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-429947 | 9.44402733683e-07 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Deadenylation of mRNA |
| WP:WP107 | 1.42815777161e-06 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Translation factors |
| REAC:R-HSA-429914 | 1.2241307173e-05 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Deadenylation-dependent mRNA decay |
| REAC:R-HSA-72649 | 1.51687690066e-05 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Translation initiation complex formation |
| REAC:R-HSA-72702 | 1.51687690066e-05 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Ribosomal scanning and start codon recognition |
| REAC:R-HSA-72662 | 1.59671252701e-05 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| CORUM:5253 | 2.05032700758e-05 | 0.666666666667 | EIF4A1 EIF4G1 | MNK1-eIF4F complex |
| REAC:R-HSA-1169408 | 2.13517139789e-05 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | ISG15 antiviral mechanism |
| GO:0016281 | 2.74903317479e-05 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | eukaryotic translation initiation factor 4F complex |
| REAC:R-HSA-1169410 | 2.78281516981e-05 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Antiviral mechanism by IFN-stimulated genes |
| GO:0034518 | 5.38272230028e-05 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | RNA cap binding complex |
| REAC:R-HSA-156827 | 0.000100702074103 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | L13a-mediated translational silencing of Ceruloplasmin expression |
| REAC:R-HSA-72706 | 0.000103499353939 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| REAC:R-HSA-72613 | 0.000124543577107 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.000124543577107 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Cap-dependent Translation Initiation |
| REAC:R-HSA-913531 | 0.000409665014874 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Interferon Signaling |
| GO:0002183 | 0.000746852719164 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | cytoplasmic translational initiation |
| GO:0003743 | 0.00127301382402 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | translation initiation factor activity |
| REAC:R-HSA-72766 | 0.00183838257359 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Translation |
| GO:0008135 | 0.00526161104852 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | translation factor activity, RNA binding |
| WP:WP4549 | 0.0067573392711 | 0.666666666667 | EIF4A1 EIF4G1 | Fragile X syndrome |
| GO:0090079 | 0.00949377645712 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | translation regulator activity, nucleic acid binding |
| REAC:R-HSA-1280215 | 0.01747853546 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Cytokine Signaling in Immune system |
| GO:0006413 | 0.0180186629002 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | translational initiation |
| GO:0045182 | 0.0207446272651 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | translation regulator activity |
| REAC:R-HSA-8953854 | 0.0247774527734 | 1.0 | EIF4A1 EIF4G1 EIF4A2 | Metabolism of RNA |
| CORUM:1308 | 0.0499402709677 | 0.333333333333 | EIF4G1 | PABPC1-HSPA8-HNRPD-EIF4G1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4A1 | EIF4A2 | 0.997 | 0.392 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction treiber_WMM | |
| EIF4G1 | EIF4A1 | 0.993 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| EIF4G1 | EIF4A2 | 0.934 |
structurally_consistent (dimer)
|
youn () bioplex_WMM bioplex3_WMM fraction treiber_WMM |
Related Complexes