hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_00976.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KPNB1 | Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97) | 5 | UniProt NCBI |
| KPNA3 | Importin subunit alpha-4 (Importin alpha Q2) (Qip2) (Karyopherin subunit alpha-3) (SRP1-gamma) | 5 | UniProt NCBI |
| KPNA2 | Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6142 | 3.41752350426e-06 | 0.666666666667 | KPNB1 KPNA2 | KPNA2-KPNB1 complex |
| REAC:R-HSA-168276 | 3.62549863672e-06 | 1.0 | KPNA3 KPNB1 KPNA2 | NS1 Mediated Effects on Host Pathways |
| GO:0042564 | 8.07408345042e-06 | 1.0 | KPNA3 KPNB1 KPNA2 | NLS-dependent protein nuclear import complex |
| KEGG:03013 | 8.70565480728e-06 | 1.0 | KPNA3 KPNB1 KPNA2 | Nucleocytoplasmic transport |
| GO:0031074 | 1.58598067776e-05 | 1.0 | KPNA3 KPNB1 KPNA2 | nucleocytoplasmic transport complex |
| REAC:R-HSA-1169408 | 2.13517139789e-05 | 1.0 | KPNA3 KPNB1 KPNA2 | ISG15 antiviral mechanism |
| REAC:R-HSA-1169410 | 2.78281516981e-05 | 1.0 | KPNA3 KPNB1 KPNA2 | Antiviral mechanism by IFN-stimulated genes |
| KEGG:05207 | 3.7014626318e-05 | 1.0 | KPNA3 KPNB1 KPNA2 | Chemical carcinogenesis - receptor activation |
| GO:0061608 | 5.38272230028e-05 | 1.0 | KPNA3 KPNB1 KPNA2 | nuclear import signal receptor activity |
| GO:0006607 | 7.84339535184e-05 | 1.0 | KPNA3 KPNB1 KPNA2 | NLS-bearing protein import into nucleus |
| GO:0008139 | 0.000148024863258 | 1.0 | KPNA3 KPNB1 KPNA2 | nuclear localization sequence binding |
| REAC:R-HSA-168255 | 0.000247017307115 | 1.0 | KPNA3 KPNB1 KPNA2 | Influenza Infection |
| GO:0140142 | 0.000281151120149 | 1.0 | KPNA3 KPNB1 KPNA2 | nucleocytoplasmic carrier activity |
| REAC:R-HSA-913531 | 0.000409665014874 | 1.0 | KPNA3 KPNB1 KPNA2 | Interferon Signaling |
| GO:0005048 | 0.000878441055398 | 1.0 | KPNA3 KPNB1 KPNA2 | signal sequence binding |
| REAC:R-HSA-9692916 | 0.00478550282195 | 0.666666666667 | KPNB1 KPNA2 | SARS-CoV-1 activates/modulates innate immune responses |
| GO:0140104 | 0.00789722257484 | 1.0 | KPNA3 KPNB1 KPNA2 | molecular carrier activity |
| REAC:R-HSA-1280215 | 0.01747853546 | 1.0 | KPNA3 KPNB1 KPNA2 | Cytokine Signaling in Immune system |
| GO:0006606 | 0.0175038439602 | 1.0 | KPNA3 KPNB1 KPNA2 | protein import into nucleus |
| GO:0051170 | 0.0201788647033 | 1.0 | KPNA3 KPNB1 KPNA2 | import into nucleus |
| CORUM:7543 | 0.0249718442456 | 0.333333333333 | KPNB1 | KPNB1-SMN-SPN complex |
| REAC:R-HSA-9824446 | 0.0269033233908 | 1.0 | KPNA3 KPNB1 KPNA2 | Viral Infection Pathways |
| REAC:R-HSA-9692914 | 0.0290482612381 | 0.666666666667 | KPNB1 KPNA2 | SARS-CoV-1-host interactions |
| HPA:0570782 | 0.0440355061936 | 1.0 | KPNA3 KPNB1 KPNA2 | testis; preleptotene spermatocytes[>=Medium] |
| CORUM:6143 | 0.0499402709677 | 0.333333333333 | KPNB1 | KPNB1-RAN complex |
| REAC:R-HSA-5663205 | 0.0499835710674 | 1.0 | KPNA3 KPNB1 KPNA2 | Infectious disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KPNB1 | KPNA2 | 0.999 | 0.26 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| KPNA3 | KPNA2 | 0.996 | 0.198 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM |
| KPNB1 | KPNA3 | 0.981 | 0.236 | hein_WMM bioplex_WMM bioplex3_WMM hein () fraction treiber_WMM |
Related Complexes